Psychopathology in pediatric bone marrow transplantation survivors and their mothers

Adanır, Aslı Sürer; Taşkıran, Gülseren; Küpesiz, Osman Alphan; Özatalay, Esin

doi:10.1111/ped.13344

Cited by 12 publications

(8 citation statements)

References 20 publications

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“…TA B L E 1 Baseline (perioperative) characteristics of pediatric transplant patients symptoms, indicating a high risk for PTSD. The prevalence of PTSS in the current study is similar to reports in pediatric bone marrow transplant recipients, 28 pediatric cancer survivors, 29 and a sample of adolescent heart, kidney, and liver recipients (in which 16.3% of the sample met all symptom criteria for PTSD). 11 However, tools other than the CTSQ were employed in the above studies to measure the prevalence of PTSS.…”

Section: Discussionsupporting

confidence: 82%

Post‐traumatic stress as a determinant of quality of life in pediatric solid‐organ transplant recipients

Hind

Lui

Moon

et al. 2021

Pediatric Transplantation

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Living with end-stage organ failure is associated with an accumulation of traumatic medical events, and despite recovery after solid-organ transplantation (SOT), many children continue to exhibit lower quality of life (QOL). Few studies have examined the relationship between post-traumatic stress disorder (PTSD) and QOL among pediatric SOT recipients. We conducted a retrospective, cross-sectional review of 61 pediatric SOT recipients (12 heart, 30 kidney, and 19 liver) to evaluate the association of PTSD with self-reported QOL. PTSD was measured by the Child Trauma Screening Questionnaire (CTSQ), and QOL was measured using the PedsQL and PedsQL Transplant Module (PedsQL-TM) surveys. Demographics, baseline, and contemporaneous factors were tested for independent association. SOT recipients were 15.2 (12.1-17.6) years old at survey completion. Median CTSQ score was 2 (1-3), highest in kidney recipients, and 13% were identified as high risk for PTSD. Median PedsQL score was 83 (70-91) and significantly associated with the CTSQ score (r = −.68, p < .001). Median PedsQL Transplant Module score was 89 (83-95) and similarly associated with the CTSQ score (r = −.64, p < .001). Age at time of surveys and presence of any disability were also independently associated with PedsQL and PedsQL-TM, respectively. When adjusted for Emotional Functioning, CTSQ remained associated with PedsQL subscores (r = −.65, p < .001). Trauma symptoms are a major modifiable risk factor for lower self-perceived QOL and represent a potentially important target for post-transplant rehabilitation. Additional research is needed to understand the root contributors to PTSD and potential treatments in this population.

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Section: Discussionsupporting

confidence: 82%

Post‐traumatic stress as a determinant of quality of life in pediatric solid‐organ transplant recipients

Hind

Lui

Moon

et al. 2021

Pediatric Transplantation

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“…This research used the K-SADS-PL and reported that the incidence of anxiety disorder was significantly higher for transplant children compared with healthy peers. 31 A study by Zanato et al reported that children undergoing BMT had more attention problems compared with healthy peers. 32 Although ADHD is a well-known neurodevelopmental disease, Nylander et al reported that the ADHD rate was higher in adolescents with chronic illness than in healthy adolescents.…”

Section: Discussionmentioning

confidence: 99%

A Spectrum of Clinical Findings from ALPS to CVID: Several Novel LRBA Defects

et al. 2019

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Objective:To analyze the development of psychopathology in recipients along with their donor and nondonor siblings and the relationship with the bone marrow transplantation (BMT) process.Methods: All children were interviewed using the Kiddie Schedule for Affective Disorders and Schizophrenia to assess psychopathology. The depression and anxiety symptoms and self-esteem of children and adolescents were evaluated using the Children's Depression Inventory, State-Trait Anxiety Inventory for Children, State-Trait Anxiety Inventory, and Rosenberg Self-Esteem Scale.Results: In this study, the depressive symptom level was found significantly higher in the donor group compared with the nondonor group. State anxiety symptoms were higher in the BMT group (P < .05). There were no significant differences in trait anxiety symptoms. Self-respect was higher in children in the donor group compared with those in the BMT group (P < .05). During the transplant process, children with bone marrow transplants had a higher prevalence of depression, anxiety disorder, and attention-deficit/hyperactivity disorder, and nondonor siblings had a higher prevalence of depressive disorder, anxiety disorder, and attention-deficit/hyperactivity disorder compared with society in general. Conclusion:Physicians should deal with the family as a whole, not just their patient, and should be aware of the psychiatric risk of other siblings during the assessment.

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“…In the literature, there is one study that used a semi‐structured interview for children undergoing BMT. This research used the K‐SADS‐PL and reported that the incidence of anxiety disorder was significantly higher for transplant children compared with healthy peers . A study by Zanato et al reported that children undergoing BMT had more attention problems compared with healthy peers .…”

Section: Discussionmentioning

confidence: 98%

Pediatric bone marrow transplantation: Psychopathologic features in recipients along with siblings

et al. 2019

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Objective: To analyze the development of psychopathology in recipients along with their donor and nondonor siblings and the relationship with the bone marrow transplantation (BMT) process.Methods: All children were interviewed using the Kiddie Schedule for Affective Disorders and Schizophrenia to assess psychopathology. The depression and anxiety symptoms and self-esteem of children and adolescents were evaluated using the Children's Depression Inventory, State-Trait Anxiety Inventory for Children, State-Trait Anxiety Inventory, and Rosenberg Self-Esteem Scale.Results: In this study, the depressive symptom level was found significantly higher in the donor group compared with the nondonor group. State anxiety symptoms were higher in the BMT group (P < .05). There were no significant differences in trait anxiety symptoms. Self-respect was higher in children in the donor group compared with those in the BMT group (P < .05). During the transplant process, children with bone marrow transplants had a higher prevalence of depression, anxiety disorder, and attention-deficit/hyperactivity disorder, and nondonor siblings had a higher prevalence of depressive disorder, anxiety disorder, and attention-deficit/hyperactivity disorder compared with society in general. Conclusion:Physicians should deal with the family as a whole, not just their patient, and should be aware of the psychiatric risk of other siblings during the assessment.

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Psychopathology in pediatric bone marrow transplantation survivors and their mothers

Abstract: Bone marrow transplantation is a significant stressor, especially for mothers. Clinicians should address the child and family as a whole in assessments and be aware of psychiatric symptoms in mothers and children who have had such a life-threatening condition.

Cited by 12 publications

References 20 publications

Post‐traumatic stress as a determinant of quality of life in pediatric solid‐organ transplant recipients

Post‐traumatic stress as a determinant of quality of life in pediatric solid‐organ transplant recipients

A Spectrum of Clinical Findings from ALPS to CVID: Several Novel LRBA Defects

Pediatric bone marrow transplantation: Psychopathologic features in recipients along with siblings

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