Psychopathology in the young offspring of parents with bipolar disorder: A controlled pilot study

Hirshfeld‐Becker, Dina R.; Biederman, Joseph; Henin, Aude; Faraone, Stephen V.; Dowd, Stephanie T.; Petrillo, Lillian A. De; Markowitz, Sarah; Rosenbaum, Jerrold F.

doi:10.1016/j.psychres.2005.08.026

Cited by 73 publications

(58 citation statements)

References 76 publications

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“…In addition, Hirshfeld-Becker et al 10 reported that offspring of bipolar parents had significantly higher rates of disruptive behavior and anxiety disorders than did both offspring of parents with panic or major depression disorders and offspring of parents with neither mood or anxiety disorders. Singh et al 33 also found higher rates of psychopathology in bipolar offspring as compared to controls' offspring (respectively, 78% had at least one DSM-IV Axis I diagnosis compared to only 24% in controls).…”

Section: Discussionmentioning

confidence: 99%

“…These findings are concordant with those suggesting that an anxiety disorder might be an alternative pathway for the further development of BD. 7 Hirshfeld-Becker et al 10 studied a sample of children with a mean age of 6.8 years and described significantly higher rates of disruptive behavior and anxiety disorders in bipolar offspring than in offspring of both parents with panic or major depression and parents with neither mood nor anxiety disorders. Wals et al found that daughters of bipolar parents obtained significantly higher scores on the following CBCL scales: Total Problems, Internalizing, Externalizing, Somatic Complaints, Anxious/Depressed, Social problems, Delinquent Behavior and Aggressive Behavior; and sons of bipolar parents obtained significantly higher scores on the Total Problems, Externalizing, Thought Problems and Aggressive Behavior scales than the normative sample.…”

Section: Introductionmentioning

confidence: 99%

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The prevalence of psychopathology in offspring of bipolar women from a Brazilian tertiary center

Benetti

Gutt

Krelling

et al. 2009

Rev. Bras. Psiquiatr.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The prevalence of psychopathology in offspring of bipolar women from a Brazilian tertiary center

Benetti

Gutt

Krelling

et al. 2009

Rev. Bras. Psiquiatr.

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“…Behavioral genetic data and molecular genetic studies to date support both genetic and environmental contributions to EOBP (Geller et al 2006). BP is familial (Geller et al 2006;Hirshfeld-Becker et al 2006;Brotman et al 2007;Rende et al 2007), and considerable research has focused on genetic risk factors for BP in adults (Hayden and Nurnberger 2006). Far less genetic research has been done on EOBP.…”

Section: Topic #8: Geneticsmentioning

confidence: 99%

AACAP 2006 Research Forum—Advancing Research in Early-Onset Bipolar Disorder: Barriers and Suggestions

Carlson

Findling

Post

et al. 2009

Journal of Child and Adolescent Psychopharmacology

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Objective: The 2006 Research Forum addressed the goal of formulating a research agenda for early-onset bipolar disorder (EOBP) and improving outcome by understanding the risk and protective factors that contribute to its severity and chronicity. Method: Five work groups outlined barriers and research gaps in EOBP genetics, neuroimaging, prodromes, psychosocial factors, and pharmacotherapy. Results: There was agreement that the lack of consensus on the definition and diagnosis of EOBP is the primary barrier to advancing research in BP in children and adolescents. Related issues included: the difficulties in managing co-morbidity both statistically and clinically; acquiring adequate sample sizes to study the genetics, biology, and treatment; understanding the EOBP's developmental aspects; and identifying environmental mediators and moderators of risk and protection. Similarly, both psychosocial and medication treatment strategies for children with BP are hamstrung by diagnostic issues. To advance the research in EOBP, both training and funding mechanisms need to be developed with these issues in mind. Conclusions: EOBP constitutes a significant public health concern. Barriers are significant but identifiable and thus are not insurmountable. To advance the understanding of EOBP, the field must be committed to resolving diagnostic and assessment issues. Once achieved, with adequate personnel and funding resources, research into the field of EOBP will doubtless be advanced at a rapid pace.

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“…Furthermore, early onset can especially have more destructive effects in this regard. Therefore, early diagnosis and prompt intervention can be very important in preventing future negative consequences and improving the performance level of this group of children (14).…”

Section: Introductionmentioning

confidence: 99%

Comparing Mental Health of School-Age Children of Parents With/Without Bipolar Disorders: A Case Control Study

Shamsaei¹,

Cheraghi²,

Dehghani³

et al. 2015

Avicenna J Neuro Psycho Physiology

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Background: Children of parents with bipolar disorder appear to have an increased risk of early-onset Bipolar Disorder (BP), mood disorders and other psychiatric disorders. Objectives: The aim of this study was to compare the mental health of school-age children of parents, with/without bipolar disorder. Materials and Methods: This case-control study included one hundred children aged six to twelve years, who had parents with bipolar disorder and 200 children of 163 demographically-matched control parents. Parents with bipolar disorder were recruited from Farshchian Psychiatric Hospital of Hamadan, Iran, during year 2014. The parent version of the Child Symptom Inventory-4 questionnaire was used to measure mental health. Mean comparisons were performed using Student's t test while effect sizes were estimated by Cohen's d coefficient. The Chi-square test was used to assess significant differences between frequency distribution of demographic variables in both groups. The significance level was considered less than 0.05. Results: There were statistically significant differences between children of parents with and those without bipolar disorder regarding attention deficit hyperactivity disorder, oppositional defiant disorder, conduct, generalized anxiety disorder, schizophrenia, major depression, separation anxiety (P< 0.001) and social phobia (P < 0.05). Children of parents with BP are at high risk for psychiatric disorders. Conclusions: These findings support that the careful evaluation and prospective following of the psychopathology of children of parents with bipolar disorder are critical for early identification and treatment.

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Psychopathology in the young offspring of parents with bipolar disorder: A controlled pilot study

Cited by 73 publications

References 76 publications

The prevalence of psychopathology in offspring of bipolar women from a Brazilian tertiary center

The prevalence of psychopathology in offspring of bipolar women from a Brazilian tertiary center

AACAP 2006 Research Forum—Advancing Research in Early-Onset Bipolar Disorder: Barriers and Suggestions

Comparing Mental Health of School-Age Children of Parents With/Without Bipolar Disorders: A Case Control Study

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