Psychopharmacological studies on<i> Tragia involucrata</i> root extract

Dhara, Amal Kumar; Pal, Saroj K.; Chaudhuri, Arabinda

doi:10.1002/ptr.891

Cited by 23 publications

(11 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After one hour each mouse was placed in turn at one corner of the board and then renders the animal to move and dip its head into the holes. The number of head dips during a 5 min period was recorded for individual mouse [19][20][21].…”

Section: Hole Board Testmentioning

confidence: 99%

An in vivo study regarding analgesic and anxiolytic activity of methanolic extract of Typha elephantina Roxb

et al. 2018

View full text Add to dashboard Cite

Background: Typha elephantina Roxb. is a widely scattered grass like medicinal plant in Bangladesh and thus demands biological investigations to discover its therapeutic potentiality. The aim of our present study was to assess analgesic and anxiolytic properties of methanolic extract of Typha elephantina Roxb. Methods: For evaluating analgesic activity, the methanolic extract was subjected to intraperitoneally (i.p.) administered acetic acid-induced writhing test & subcutaneously administered (s.c.) formalin-induced hind paw licking test in Swiss-albino mice. The anxiolytic activity was conducted by using elevated plus maze (EPM) and hole board models. Results: For both methods of analgesic test experimental plant extract was found to have significant (p < 0.001) analgesia at the dose of 200 mg/kg & 400 mg/kg body weight in mice when compared to control, where acetyl salicylic acid (100 mg/kg body weight) was used as standard drug. The percentages of inhibition found in case of acetic acid-induced writhing test were 26.27%, 50.45% and 20.29% respectively for acetyl salicylic acid (100 mg/kg), 200 mg/kg extract dose and 400 mg/kg extract dose. On the other hand, during formalin-induced hind paw licking test, the percentages of inhibition also increased when the extract dose increases from 200 mg/kg to 400 mg/kg by 53.95% to 61.79% at early phase and 71.62% to 78.8% at late phase respectively while acetyl salicylic acid (100 mg/kg), responsible for 25.58% and 38.74% of inhibition at both phase sequentially. Again, the crude extract significantly (p < 0.01; p < 0.001) raised the time spent in the open arm (149.2 ± 27.63 ** sec) & the number of head-dips (50.00 ± 4.66 *** ) at the dose 400 mg/kg body weight in case anxiolytic test, while reference drug diazepam (1 mg/kg body weight) also exhibited significant (p < 0.01) result in case of time spent in open arm (107.0 ± 12 ** sec) but not for head dipping (14.83 ± 1.6). Conclusion: Findings of the present study assure that Typha elephantina Roxb. may be effective for the treatment of pain and anxiety with the demands of further investigations to isolate the active compound(s).

show abstract

Section: Hole Board Testmentioning

confidence: 99%

An in vivo study regarding analgesic and anxiolytic activity of methanolic extract of Typha elephantina Roxb

et al. 2018

View full text Add to dashboard Cite

show abstract

“…It also showed significant decrease in brain MDA level in lipid peroxidation profile, and increase in the brain glutathione levels in mice against Pentylenetetrazole induced convulsion. The Tragia involucrate possesses dose dependent antiepileptic activity 16,18 .…”

Section: Antiepileptic Activitymentioning

confidence: 99%

Phytochemical, PharmacologicalProfiles of Tragia involucrata

2018

IJCTR

View full text Add to dashboard Cite

Tragia involucrata is a slender, twining her with stinging hairs. The various activities were assessed by anti-inflammatory activity with carrageenan induced rat paw oedema, diuretic activity by Lipschitz model and anthelmintic activity by earthworm model, analgesic activity by radiant heat induced nociception. The Preliminary phytochemical investigation revealed the presence of tannins and flavanoids in petroleum ether extract of Tragia involucrata, alkaloids in chloroform extract of Tragia involucrata and saponins in aqueous extract of Tragia involucrata. All the three extracts exhibited anti-inflammatory, analgesic, diuretic and anthelmintic activities. This review provides a basis for future investigation of Tragia involucrata species and especially for those species that have not been explored for phytochemical and pharmacological activities.

show abstract

“…head-dipping); when confronted with a new environment, the natural tendency of a mouse or a rat is to explore any present hole by plunging its head in and out of the hole a few times and then moving on to the next hole. Therefore, the purpose of the Hole-Board test is to assess the effects of psychotropic drugs on the rat's head dipping and to explore its activity, where in general a high frequency of head dipping is reflective of normal neophilia while low levels of head dipping is usually indicative of high anxiety level that prevents the animal from exploring [10].…”

Section: Hole Board Testmentioning

confidence: 99%

Evaluation of Acute Toxicity and Sedative Effects of Ethylic Extract of <i>Thymelaea lythroides</i> in Wistar Rats

Berkiks¹,

Mesfioui²,

Kribii³

et al. 2014

JBBS

View full text Add to dashboard Cite

The purpose of this study was to evaluate the acute toxicity and sedative effect of the ethylic extract of Thymelaea lythroides (Tl) on Wistar rats. The study was based on the gavage administration of the ethylic extract of Tl with different doses (i.e. 200, 400, 500 and 5000 mg/kg), where the toxicity and the sedative activity of the plant were observed and the obtained results were analyzed using the ANOVA test followed by the Bonferroni test. The main results of this study showed that the lethal dose of the ethylic extract of Tl was higher than the 5000 mg/kg dose. Moreover, when compared to the control rats, the animals treated with 5000 mg/kg of the extract exhibited significant reduction in appetite for food and water in the first week. Furthermore, results of the psychotropic test conducted during this study showed visible effects on the exploratory activity of the rats. The dose of 5000 mg/kg was also found to have a significant central nervous system effect; the locomotor activities of the animals decreased in a manner similar to those administered with Zepam as control.

show abstract

Psychopharmacological studies on Tragia involucrata root extract

Cited by 23 publications

References 8 publications

An in vivo study regarding analgesic and anxiolytic activity of methanolic extract of Typha elephantina Roxb

An in vivo study regarding analgesic and anxiolytic activity of methanolic extract of Typha elephantina Roxb

Phytochemical, PharmacologicalProfiles of Tragia involucrata

Evaluation of Acute Toxicity and Sedative Effects of Ethylic Extract of <i>Thymelaea lythroides</i> in Wistar Rats

Contact Info

Product

Resources

About

Psychopharmacological studies on Tragia involucrata root extract

Cited by 23 publications

References 8 publications

An in vivo study regarding analgesic and anxiolytic activity of methanolic extract of Typha elephantina Roxb

An in vivo study regarding analgesic and anxiolytic activity of methanolic extract of Typha elephantina Roxb

Phytochemical, PharmacologicalProfiles of Tragia involucrata

Evaluation of Acute Toxicity and Sedative Effects of Ethylic Extract of &lt;i&gt;Thymelaea lythroides&lt;/i&gt; in Wistar Rats

Contact Info

Product

Resources

About

Evaluation of Acute Toxicity and Sedative Effects of Ethylic Extract of <i>Thymelaea lythroides</i> in Wistar Rats