Psychopharmacology and Aggression. I: A Meta-Analysis of Stimulant Effects on Overt/Covert Aggression–Related Behaviors in ADHD

Connor, Daniel F.; Glatt, Stephen J.; Lopez, Isabella; Jackson, Denise; Melloni, Richard H.

doi:10.1097/00004583-200203000-00004

Cited by 314 publications

(176 citation statements)

References 47 publications

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“…In the case of nonsuccess and when there are risks to the patients or the people that live with them, the treatment should include approaches directed to the aggressive behavior specifically. 12,[17][18][19] The use of psychopharmacologic drugs for patients in this age group should take into consideration the characteristic of their metabolism, drug pharmacokinetics and pharmacodynamics, and the risk of specific drug interactions. Children and adolescents, in general, are rapid metabolizers and, therefore, need antipsychotic doses that are proportionally higher in relation to their weight.…”

Section: Resultsmentioning

confidence: 99%

Atypical antipsychotics in the treatment of pathological aggression in children and adolescents: literature review and clinical recommendations

Teixeira

Jacintho

Celeri

et al. 2013

Trends Psychiatry Psychother.

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Objective: To review the literature about the use of atypical antipsychotics in the treatment of pathological aggression in children and adolescents. Method: The databases MEDLINE, SciELO, and LILACS were searched for publications in Portuguese or English from 1992 to August 2011 using the following keywords: mental disease, child, adolescent, treatment, atypical antipsychotic, aggressive behavior, aggression, and violent behavior. Results: Sixty-seven studies of good methodological quality and clinical interest and relevance were identified. Studies including children and adolescents were relatively limited, because few atypical antipsychotics have been approved by the Food and Drug Administration (FDA). All the medications included in this review (risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole and clozapine) have some effectiveness in treating aggression in children and adolescents, and choices should be based on clinical indications and side effects. Conclusions: There are few studies about the effectiveness and safety of atypical antipsychotics for the pediatric population, and further randomized controlled studies with larger groups of patients and more diagnostic categories, such as severe conduct disorder and oppositional defiant disorder, should be conducted to confirm the results reported up to date and to evaluate the impact of long-term use. Keywords: Aggression, violence, atypical antipsychotics, behavioral disorders, children, adolescents. ResumoObjetivo: Realizar uma revisão sistemática da literatura científica sobre o uso de antipsicóticos atípicos (APAs) no tratamento da agressividade patológica em crianças e adolescentes. Método: Foi realizada busca eletrônica nas bases de dados MEDLINE, SciELO e LILACS, de 1992 a agosto 2011, considerando artigos publicados em língua inglesa e portuguesa. Foram utilizadas associações das seguintes expressões: mental disease, child, adolescent, treatment, atypical antipsychotic, aggressive behaviour, aggression e violent behavior. Resultados: Foram identificados 67 artigos de boa qualidade metodológica, de relevância e interesse clínico para o tema em foco. De modo geral, os estudos são relativamente limitados para esta faixa etária, resultado do fato de poucos APAs terem sido aprovados pela Food and Drug Administration (FDA). Dentre as medicações consideradas nesta revisão (risperidona, olanzapina, quetiapina, ziprazidona, aripiprazol e clozapina), todas elas podem ter alguma efetividade no tratamento da agressividade em crianças e adolescentes, ficando a escolha baseada na indicação clínica e perfil de efeitos colaterais. Conclusão: O número ainda limitado de estudos acerca da efetividade e segurança na população pediátrica demanda pesquisas futuras com grupos maiores de pacientes e com mais categorias diagnósticas (como, por exemplo, as formas graves de transtorno de conduta e transtorno desafiador de oposição), desenhadas de forma randomizada e controlada. Assim poderão ser confirmados os achados até o momento e o impacto do uso em lo...

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Section: Resultsmentioning

confidence: 99%

Atypical antipsychotics in the treatment of pathological aggression in children and adolescents: literature review and clinical recommendations

Teixeira

Jacintho

Celeri

et al. 2013

Trends Psychiatry Psychother.

View full text Add to dashboard Cite

show abstract

“…Stimulants also have similarly robust effects on oppositional/defiant behaviors and overt aggression (Connor 2006;Connor et al, 2002;Pliszka, 2009), especially when an optimal medication regimen is combined with behavior therapy (Blader et al, 2010). Perhaps the best indication of the efficacy of treating children comorbid for ADHD/ODD comes from the largest randomized control study to date, the Multimodal Treatment Study of ADHD, in which 40% of the participants had ODD or CD (Smith, Barkley, Shapiro, 2006).…”

Section: Pharmacological Treatmentmentioning

confidence: 99%

Attention Deficit Hyperactivity Disorder and Males in the Juvenile Justice System

Eme¹

2012

Contemporary Trends in ADHD Research

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“…Uma vez que indivíduos anti-sociais/agressivos apresentam baixos níveis de serotonina, medicações que aumentam a disponibilidade de serotonina (como inibidores seletivos da recaptação de serotonina), devem diminuir o comportamento anti-social se houver uma conexão causal. Há evidências que apóiam essa previsão em crianças e adultos agressivos 15 .…”

Section: Implicações Do Tratamentounclassified

O crime biológico: implicações para a sociedade e para o sistema de justiça criminal

Raine

2008

Rev. psiquiatr. Rio Gd. Sul

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Psychopharmacology and Aggression. I: A Meta-Analysis of Stimulant Effects on Overt/Covert Aggression–Related Behaviors in ADHD

Cited by 314 publications

References 47 publications

Atypical antipsychotics in the treatment of pathological aggression in children and adolescents: literature review and clinical recommendations

Atypical antipsychotics in the treatment of pathological aggression in children and adolescents: literature review and clinical recommendations

Attention Deficit Hyperactivity Disorder and Males in the Juvenile Justice System

O crime biológico: implicações para a sociedade e para o sistema de justiça criminal

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