Psychophysiological and clinical value of event-related potentials in obsessive-compulsive disorder

Morault, P; Bourgeois, M; Laville, Jérôme; Bensch, C; Paty, J

doi:10.1016/s0006-3223(96)00228-4

Cited by 57 publications

(50 citation statements)

References 28 publications

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“…The OCD and the GTS+OCD group showed reduced rare-target P300 amplitude, mainly in the right anterior region, but otherwise did not differ significantly from each other. The target P300 amplitude was also negatively correlated with OCD, which confirmed numerous findings reported in OCD (Beech, Ciesielski, & Gordon, 1983;Malloy, Rasmussen, Braden, & Haier, 1989;Miyata et al, 1998;Morault, Guillem, Bourgeois, & Paty, 1998;Morault, Bourgeois, Laville, Bensch, & Paty, 1997;Oades, Dittmann-Balcar, Schepker, Eggers, & Zerbin, 1996;Sanz, Molina, Martin-Loeches, Calcedo, & Rubia, 2001;Towey et al, 1994). Conversely, participants suffering from GTS showed larger target P300 amplitude, positively correlated with tic frequency.…”

Section: Inhibitory and Sensorimotor Integration Specificity In Gtssupporting

confidence: 87%

Neurocognitive Aspects of Tourette Syndrome and Related Disorders

Lavoie¹,

O’Connor²

2012

When Things Go Wrong - Diseases and Disorders of the Human Brain

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Section: Inhibitory and Sensorimotor Integration Specificity In Gtssupporting

confidence: 87%

Neurocognitive Aspects of Tourette Syndrome and Related Disorders

Lavoie¹,

O’Connor²

2012

When Things Go Wrong - Diseases and Disorders of the Human Brain

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“…Longer N1 latency to Go stimuli has previously been reported for OCD participants versus healthy controls (Di Russo, Zaccara, Ragazzoni, & Pallanti, 2000;Morault, Bourgeois, Laville, Bensch, & Paty, 1997) however the current study demonstrates that this is not an OCD-23 specific anomaly. The current results suggest slower or more effortful processing during stimulus discrimination in both clinical groups.…”

Section: Other Between-group Differencessupporting

confidence: 44%

Electrophysiology of facilitation priming in obsessive–compulsive and panic disorders

Thomas

Gonsalvez

Johnstone

2016

Clinical Neurophysiology

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Objective: Repeated experience with stimuli often primes faster, more efficient neuronal and behavioural responses. Exaggerated repetition priming effects have previously been reported in obsessive-compulsive disorder (OCD), however little is known of their underlying neurobiology or disorder-specificity, hence we investigated these factors. Methods: We examined event-related potentials (ERPs) and behaviour while participants with OCD, panic disorder and healthy controls (20 per group) performed a Go/NoGo task which manipulated target repetition sequences. Results: Both clinical groups showed stronger reaction time (RT) priming than HCs, which in OCD was greater in a checking, than washing, subgroup. Both clinical groups had similar RT deficits and ERP anomalies across several components, which correlated with psychopathology and RT priming. In OCD alone, N1 latency tended to increase to repeated stimuli, correlated with O-C symptoms, whereas it decreased in other groups. OCD-checkers had smaller target P2 amplitude than all other groups. Conclusions: Enhanced neural priming is not unique to OCD and may contribute to salient sensory-cognitive experiences in anxiety generally. These effects are related to symptom severity and occur to neutral stimuli and in the context of overall RT impairment, suggesting they may be clinically relevant and pervasive. The results indicate overlapping information-processing and neurobiological factors across disorders, with indications of OCD-specific trends and subgroup differences. Significance: This first electrophysiological investigation of OCD priming in OCD to include anxious controls and OCD subgroups allows for differentiation between overlapping and OCD-specific phenomena, to advance neurobiological models of OCD. The authors report no conflicts of interest. Highlights• We conducted the first electrophysiological investigation of repetition priming in obsessive-compulsive disorder (OCD) to include anxious and healthy controls and the first ERP study to consider OCD symptom subgroups.• Repetition priming was exaggerated in both OCD and panic disorder, and related to atypical ERP topography and symptom severity.• P2 amplitude to targets was significantly smaller in a non-washing/checking subgroup of OCD than all other groups. 3 AbstractObjective: Repeated experience with stimuli often primes faster, more efficient neuronal and behavioural responses. Exaggerated repetition priming effects have previously been reported in obsessive-compulsive disorder (OCD), however little is known of their underlying neurobiology or disorder-specificity, hence we investigated these factors. Methods:We examined event-related potentials (ERPs) and behaviour while participants with OCD, panic disorder and healthy controls (20 per group) performed a Go/ NoGo task which manipulated target repetition sequences. Results:Both clinical groups showed stronger reaction time (RT) priming than HCs, which in OCD was greater in a checking, than washing, subgroup. Both clinical groups had similar R...

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“…However, our sample size compares to earlier samples in the ERP field, which used GTS patients samples at n=6 (Van de Wetering et al, 1985), n=10 (Johannes et al, 2001a(Johannes et al, ,b, 2003, n=12 (Johannes et al, 1997) and n=24 (van Woerkom et al, 1994). The same applies with ERP studies of OCD patients with various sample sizes from a n=8 (Di Russo et al, 2000), n=9 (Gehring et al, 2000), n=13 (Morault et al, 1997), n=15 (Sanz et al, 2001) and n=21 (Morault et al, 1998). Future research would ideally recruit larger samples and compare GTS+OCS with other comorbid groups such as highly anxious, depressive or hyperactive GTS patients.…”

Section: Possible Influences Of Confounding Variablesmentioning

confidence: 90%

Influence of comorbid obsessive-compulsive symptoms on brain event-related potentials in Gilles de la Tourette syndrome

Thibault

Felezeu

O’Connor

et al. 2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Approximately 30 to 50% of people suffering from Gilles de la Tourette Syndrome (GTS) also fulfill diagnostic criteria for obsessive-compulsive disorder (OCD). Despite this high degree of comorbidity, very few studies have addressed the question of obsessive-compulsive symptoms (OCS) in GTS patients using specific brain event-related potentials (ERP) responses. The aim of the current study was to quantify neurocognitive aspects of comorbidity, using ERPs. Fourteen adults with GTS (without OCD) were compared to a group of 12 participants with GTS and comorbid obsessive-compulsive symptoms (GTS+OCS), to a group of 15 participants with OCD and to a group of 14 control participants without neurological or psychiatric problems. The P200 and P300 components were recorded during a visual counting oddball task. Results showed intact P200 amplitude in all groups, whilst the P300 amplitude was affected differentially across groups. The P300 oddball effect was reduced in participants in both OCD and GTS+OCS groups in the anterior region. However, the P300 oddball effect was significantly larger in participants of the GTS group compared to all other groups, mostly in the parietal region. These findings suggest that adults with GTS are characterized by enhanced working memory updating processes and that the superimposition of OCS can lead to a reduction of these processes. The discrepancy between our findings and results obtained in previous studies on GTS could reflect the modulating effect of OCS on late ERP components.

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Psychophysiological and clinical value of event-related potentials in obsessive-compulsive disorder

Cited by 57 publications

References 28 publications

Neurocognitive Aspects of Tourette Syndrome and Related Disorders

Neurocognitive Aspects of Tourette Syndrome and Related Disorders

Electrophysiology of facilitation priming in obsessive–compulsive and panic disorders

Influence of comorbid obsessive-compulsive symptoms on brain event-related potentials in Gilles de la Tourette syndrome

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