Psychophysiological treatment of chronic tinnitus: A review

Czornik, Manuel; Malekshahi, Azim; Mahmoud, Wala; Wolpert, Samuel M.; Birbaumer, Niels

doi:10.1002/cpp.2708

Cited by 25 publications

(11 citation statements)

References 106 publications

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“…The benefit lies in changing variables that maintain psychological distress and which are addressed by psychological therapy. As such, results are in line with research that pinpoints psychological treatment approaches as gold standard for treating chronic tinnitus 29 . PT2 showed highest above-average improvement in depression and apathy.…”

Section: Resultssupporting

confidence: 83%

Heterogeneity in response to treatment across tinnitus phenotypes

Niemann,

Boecking,

Brueggemann

et al. 2024

Sci Rep

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The clinical heterogeneity of chronic tinnitus poses major challenges to patient management and prompts the identification of distinct patient subgroups (or phenotypes) that respond more predictable to a particular treatment. We model heterogeneity in treatment response among phenotypes of tinnitus patients concerning their change in self-reported health burden, psychological characteristics, and tinnitus characteristics. Before and after a 7-day multimodal treatment, 989 tinnitus patients completed 14 assessment questionnaires, from which 64 variables measured general tinnitus characteristics, quality of life, pain experiences, somatic expressions, affective symptoms, tinnitus-related distress, internal resources, and perceived stress. Our approach encompasses mechanisms for patient phenotyping, visualizations of the phenotypes and their change with treatment in a projected space, and the extraction of patient subgroups based on their change with treatment. On average, all four distinct phenotypes identified at the pre-intervention baseline showed improved values for nearly all the considered variables following the intervention. However, a considerable intra-phenotype heterogeneity was noted. Five clusters of change reflected variations in the observed improvements among individuals. These patterns of treatment effects were identified to be associated with baseline phenotypes. Our exploratory approach establishes a groundwork for future studies incorporating control groups to pinpoint patient subgroups that are more likely to benefit from specific treatments. This strategy not only has the potential to advance personalized medicine but can also be extended to a broader spectrum of patients with various chronic conditions.

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Section: Resultssupporting

confidence: 83%

Heterogeneity in response to treatment across tinnitus phenotypes

Niemann,

Boecking,

Brueggemann

et al. 2024

Sci Rep

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“…Therefore, extensive research has been devoted to identifying neural correlates of conscious tinnitus perception by comparing spontaneous resting state brain activity oscillations in individuals with and without tinnitus, using non-invasive recording methods obtained in non-invasive silence, such as magnetoencephalography (MEG) or electroencephalography (EEG). In response to the theory of abnormal oscillatory behavior in tinnitus and its supporting evidence, many proposed treatments aim to directly or indirectly alter oscillatory activity with the aim of alleviating symptoms, such as transcranial magnetic stimulation ( Londero et al, 2018 ; Dong et al, 2020 ; Pink et al, 2021 ), transcranial direct current stimulation ( Santos et al, 2018 ; Wang et al, 2018 ; Labree et al, 2021 ), neurofeedback ( Güntensperger et al, 2017 ; Kleinjung et al, 2018 ; Czornik et al, 2022 ), alternating current stimulation, transcranial random noise stimulation, transcutaneous vagus nerve stimulation, and bimodal stimulation ( Langguth, 2020 ; Yakunina and Nam, 2021 ; Herrera-Murillo et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

EEG spectral and microstate analysis originating residual inhibition of tinnitus induced by tailor-made notched music training

Zhu,

Gong

2023

Front. Neurosci.

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Tailor-made notched music training (TMNMT) is a promising therapy for tinnitus. Residual inhibition (RI) is one of the few interventions that can temporarily inhibit tinnitus, which is a useful technique that can be applied to tinnitus research and explore tinnitus mechanisms. In this study, RI effect of TMNMT in tinnitus was investigated mainly using behavioral tests, EEG spectral and microstate analysis. To our knowledge, this study is the first to investigate RI effect of TMNMT. A total of 44 participants with tinnitus were divided into TMNMT group (22 participants; ECnm, NMnm, RInm represent that EEG recordings with eyes closed stimuli-pre, stimuli-ing, stimuli-post by TMNMT music, respectively) and Placebo control group (22 participants; ECpb, PBpb, RIpb represent that EEG recordings with eyes closed stimuli-pre, stimuli-ing, stimuli-post by Placebo music, respectively) in a single-blind manner. Behavioral tests, EEG spectral analysis (covering delta, theta, alpha, beta, gamma frequency bands) and microstate analysis (involving four microstate classes, A to D) were employed to evaluate RI effect of TMNMT. The results of the study showed that TMNMT had a stronger inhibition ability and longer inhibition time according to the behavioral tests compared to Placebo. Spectral analysis showed that RI effect of TMNMT increased significantly the power spectral density (PSD) of delta, theta bands and decreased significantly the PSD of alpha2 band, and microstate analysis showed that RI effect of TMNMT had shorter duration (microstate B, microstate C), higher Occurrence (microstate A, microstate C, microstate D), Coverage (microstate A) and transition probabilities (microstate A to microstate B, microstate A to microstate D and microstate D to microstate A). Meanwhile, RI effect of Placebo decreased significantly the PSD of alpha2 band, and microstate analysis showed that RI effect of Placebo had shorter duration (microstate C, microstate D), higher occurrence (microstate B, microstate C), lower coverage (microstate C, microstate D), higher transition probabilities (microstate A to microstate B, microstate B to microstate A). It was also found that the intensity of tinnitus symptoms was significant positively correlated with the duration of microstate B in five subgroups (ECnm, NMnm, RInm, ECpb, PBpb). Our study provided valuable experimental evidence and practical applications for the effectiveness of TMNMT as a novel music therapy for tinnitus. The observed stronger residual inhibition (RI) ability of TMNMT supported its potential applications in tinnitus treatment. Furthermore, the temporal dynamics of EEG microstates serve as novel functional and trait markers of synchronous brain activity that contribute to a deep understanding of the neural mechanism underlying TMNMT treatment for tinnitus.

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“…Sleep apnea accompanied with laryngopharyngeal reflux also may affect to dry eye [ 43 , 51 ]. Sleep disorders are associated with both tinnitus and dry eye [ 48 , 49 , 50 , 52 , 53 ]. Third, tinnitus can lead to high levels of stress, anxiety, and depression [ 54 , 55 ], and medication for these psychological problems may cause dry eye [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Dry Eye Diseases and Auditory Sensitivity

Kim

Hwang

Chang

et al. 2022

JCM

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This study aimed to evaluate the association between dry eye and inner ear diseases in a Korean population. Methods: Data from the Korean National Health and Nutrition Survey (KNHANES V, 2010–2012), a national cross-sectional health examination and survey, were collected by the Korea Centers for Disease Control and Prevention. The association between dry eye and inner ear disease was determined using the chi-square test and logistic regression analysis. The individuals were divided into two age groups (<60 and ≥60 years). Results: In total, 17,542 individuals (n = 11,932 in the <60 years group and n = 5610 in the ≥60 years group) were enrolled. After adjusting for confounding factors, the logistic regression model revealed that the associated factors were dizziness and loss of balance experience (OR, 1.315; 95% CI, 1.143–1.513), self-awareness of abnormal voice (OR, 1.372; 95% CI, 1.120–1.679), subjective hearing discomfort (OR, 1.278; CI, 1.084–1.506), and tinnitus (OR, 1.265; 95% CI, 1.101–1.453). The inversely associated factor for dry eye was bilateral hearing loss (OR, 0.497; 95% CI, 0.367–0.672). The hearing threshold was lower in the dry eye group than in the non-dry eye group (p < 0.05). Conclusions: Tinnitus was associated with dry eye and bilateral hearing loss was inversely associated with dry eye. These results suggest that hypersensitivity of the senses and nerves, which is neuropathic hyperesthesia, is one of the main mechanisms of dry eye. Treatment of neuropathy may help in treating dry eye associated with dizziness or tinnitus.

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Psychophysiological treatment of chronic tinnitus: A review

Cited by 25 publications

References 106 publications

Heterogeneity in response to treatment across tinnitus phenotypes

Heterogeneity in response to treatment across tinnitus phenotypes

EEG spectral and microstate analysis originating residual inhibition of tinnitus induced by tailor-made notched music training

Association of Dry Eye Diseases and Auditory Sensitivity

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