Psychoses in Three Cases with Myasthenia Gravis and Thymoma-Proposal of a Paraneoplastic Autoimmune Neuropsychiatric Syndrome.

Musha, Morihiro; Tanaka, Fumio; Ohuti, Masahiro

doi:10.1620/tjem.169.335

Cited by 25 publications

(19 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, chronic and long standing MG has been linked to psychotic illness in several case reports. 12 Patient also was on pyridostigmine for MG which is known to have adverse event of psychosis. In our case however, psychosis had not been reported prior or after this admission, making it less likely that this psychosis was due to MG or medication.…”

Section: Discussionmentioning

confidence: 99%

Case Report of Shared Psychotic Disorder or ‘Folie a Deux’ in Two Geriatric Sisters

Patel¹,

Schindzielorz²,

Holroyd³

2017

WVMJ

View full text Add to dashboard Cite

Folie a Deux or shared psychotic disorder is a rare and poorly understood disorder characterized as transfer of delusional beliefs from one person, the primary patient, to another, the secondary patient, who are closely related. The disorder is mainly seen within a family, most often between spouses or between siblings, although it has been noted in other relationships. Females are more likely than males to both primary and secondary partner. We present a case of a 77-year-old female who was admitted for myasthenia gravis exacerbation with a two-day history of generalized weakness, multiple falls, decreased appetite and blurred vision. However, she also described a detailed and implausible story of kidnapping and extortion which, surprisingly, was validated by the patient's younger sister. Investigation of the story by police and others confirmed it to be false. A diagnosis of shared psychotic disorder was made. The delusions appeared to occur with a rapid onset and resolution. This case highlights the unusual presentation of shared psychotic disorder in two elderly women, well outside the typical age of onset for the disorder as well as its rapid onset and resolution, rather than in the setting of a chronic psychiatric illness such as delusional disorder or schizophrenia.

show abstract

Section: Discussionmentioning

confidence: 99%

Case Report of Shared Psychotic Disorder or ‘Folie a Deux’ in Two Geriatric Sisters

Patel¹,

Schindzielorz²,

Holroyd³

2017

WVMJ

View full text Add to dashboard Cite

show abstract

“…1 A literature search showed very few case reports demonstrating an association between the physiology of MG and psychiatric symptoms. In 1945, Delgado and Rosas reported one case of MG and psychosis.…”

Section: Discussionmentioning

confidence: 99%

“…They proposed a concept of paraneoplastic autoimmune neuropsychiatric syndrome. 1 This concept was refuted by Keesey et al, who suggested that the antigenic differences between the AchRs and the neuronal nicotinic acetylcholine receptors (nAchR), together with the very low concentrations of muscle antibodies in the CSF, make the claim highly unlikely that CNS cholinergic systems are affected by muscle antibodies in MG patients. 5 The patient described here was diagnosed with MG and bipolar disorder at 19 years and was hospitalized at 36 years with neuropsychiatric syndrome (NPS) symptoms, including hallucinations and emotional disturbances with psychomotor excitement, such as agitation and anger.…”

Section: Discussionmentioning

confidence: 99%

“…5 The patient described here was diagnosed with MG and bipolar disorder at 19 years and was hospitalized at 36 years with neuropsychiatric syndrome (NPS) symptoms, including hallucinations and emotional disturbances with psychomotor excitement, such as agitation and anger. Literature review uncovers a pattern in which NPS symptoms usually precede by several months to years the onset of MG and, thereafter, NPS symptoms are closely related to worsening and relapse of MG. 6 Early case histories of MG associated with psychosis described the deteriorating mental status as occurring during periods of increasing dyspnea and cyanosis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A 36-Year-Old Man with Agitated Behavior, Psychosis

Ferrer¹,

Jadapalle²

2011

Psychiatric Annals

View full text Add to dashboard Cite

“…Clinical symptoms of thymoma-related PLE are different from those of the anti-Hu-antibody-associated PLE. In addition, thymoma-related PLE responded to the treatment better than anti-Hu-antibody-associated PLE [2][3][4][5][6][7]11] . It is plausible that unknown antineuronal antibodies, predominantly affecting the limbic system, are involved in the thymoma-related PLE.…”

mentioning

confidence: 97%