Psychosis Assessment in Early-Stage Parkinson’s Disease: Comparing Parkinson’s Psychosis Questionnaire with the Brief Psychiatric Rating Scale in a Portuguese Sample

Cargaleiro, I.; Serra, Madalena; Silva, Joaquim Alves da; Neto, Bernardo Melo; Gonçalves-Pereira, Manuel; Bugalho, Paulo

doi:10.1155/2012/469126

Cited by 3 publications

(4 citation statements)

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“…Presence of positive symptoms varied across different assessment tools, most likely attributed to inconsistencies in criteria adopted by the scale. 24 As shown in Figure 1, the clinician detected the presence of hallucinations in patients who neither the patients nor their informants had reported. Based on their PDQ-39 scores, this group of patients had a poorer perceived quality of life compared to the rest of the sample.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we found differences in reported prevalence rates of hallucinations and psychosis in a large cohort of PD patients. Presence of positive symptoms varied across different assessment tools, most likely attributed to inconsistencies in criteria adopted by the scale . As shown in Figure , the clinician detected the presence of hallucinations in patients who neither the patients nor their informants had reported.…”

Section: Discussionmentioning

confidence: 99%

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Informant‐ and Self‐Appraisals on the Psychosis and Hallucinations Questionnaire (PsycH‐Q) Enhances Detection of Visual Hallucinations in Parkinson's Disease

Muller

Mills

O’Callaghan

et al. 2018

Movement Disord Clin Pract

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Background Clinicians vary in their ability to elicit and interpret hallucinatory symptoms in patients with Parkinson's disease (PD). There is limited evidence for informant‐report measures of PD hallucinations as adjuncts to clinician‐rated scales. Objectives To determine the utility of an informant version of the validated Psychosis and Hallucinations Questionnaire (PsycH‐Q) for assessing the presence and severity of hallucinations in PD; and, to evaluate accuracy of clinician judgements by comparison with informant report and self‐report. Methods One hundred sixty‐three PD patient‐informant dyads completed self‐ and informant‐report versions of PsycH‐Q and three common questionnaire measures: Neuropsychiatric Inventory Questionnaire; Parkinson's Psychosis Questionnaire; and Scales for Outcomes in Parkinson's disease–Psychiatric Complications. We compared self‐ratings and informant ratings across analogous subscales for the presence of hallucinations with clinician interview ratings on MDS‐UPDRS as a diagnostic standard. Results There was a low level of agreement between dyads (average κ = 0.39; κ range = 0.32–0.47; P < 0.001), and patients indicated the highest prevalence of hallucinations compared to informant or clinician estimates. Clinician interview missed 32% of PsycH‐Q hallucinators identified by dyads. Relative to the sample, 22 patients with exclusively clinician‐appraised hallucinations had poorer overall quality of life measured by the Parkinson's Disease Questionnaire. Conclusions The sole use of clinician‐rated scales may underestimate prevalence of PD hallucinations, and there is room for introducing self‐ and informant‐report tools. Nonetheless, clinician appraisals are critical in cases when informant and patient insight might be affected by the impact of illness on quality of life.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Informant‐ and Self‐Appraisals on the Psychosis and Hallucinations Questionnaire (PsycH‐Q) Enhances Detection of Visual Hallucinations in Parkinson's Disease

Muller

Mills

O’Callaghan

et al. 2018

Movement Disord Clin Pract

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“…Common variations in study design identified from a targeted literature review (unpublished findings) include the criteria for patient selection, the definition of PDP, the symptoms of psychosis that were of interest to study investigators, differences in the methodology used to assess symptoms, and the timeframe over which symptoms were observed. For example, several studies have reported that inclusion of minor phenomena increases the observed prevalence rate of psychosis symptoms among patients with PD [47][48][49] and that standard assessment tools for PD symptomology, such as the thought disturbance item on the Unified Parkinson Disease Rating Scale (UPDRS) Part I have low sensitivity for capturing such phenomena. 50,51 The prevalence rates in the current study were estimated based on survey data reported retrospectively by medical practitioners.…”

Section: Disruptiveness and Comorbidity Ratesmentioning

confidence: 99%

Parkinson’s Disease Psychosis – Prevalence Patterns Across the EU-5

Cook¹,

Suresh²,

Lou³

et al. 2017

European Neurological Review

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Parkinson's disease psychosis (PDP) is a clinical condition that affects patients diagnosed with Parkinson's disease (PD) and has a spectrum of neuropsychiatric symptoms distinct from the hallmark motor symptoms. Although prior studies have reported on the prevalence of PDP in select European nations, variations in study design complicate study-to-study comparisons. In this study, we surveyed 1,667 medical practitioners across France, Germany, Italy, Spain, and the UK (collectively, the EU-5) to estimate the prevalence of PDP or symptoms of psychosis among patients with PD. Analysis of the survey data suggest approximately 29% of the general PD population in the EU-5 exhibit signs of PDP. Among the PD population, country-specific rates of PDP are estimated at 30% in France, 27% in Germany, 34% in Italy, 30% in Spain and 21% in the UK. These rates appear in line with those reported in prior country-specific studies. Results from the subset of 437 neurologists who proceeded to take the full survey suggest the symptoms of PDP are disruptive to patients or their respective caregivers in approximately 53% of cases. These results provide a resource that enables cross-country comparison of PDP rates across these major European nations.

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“…[ 8 ] Therefore, the present study was undertaken to study the clinical profile of the patients with Parkinson's disease and psychosis using the neuropsychiatric inventory (NPI) for rating of psychotic symptoms. Although various scales have been used to assess psychosis in PD,[ 9 10 11 ] the NPI is a well-validated scale to screen for various psychotic symptoms in PD. [ 12 ]…”

Section: Introductionmentioning

confidence: 99%

A clinical profile of patients with Parkinson′s disease and psychosis

Amar

Yadav

Reddy

et al. 2014

Ann Indian Acad Neurol

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Aims:The aim of the study was to study the clinical profile of the patients with Parkinson's disease (PD) and psychosis.Settings and Design:This was a prospective, cross sectional, hospital-based study done at the Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India from September 2009 to January 2011. All patients with PD, diagnosed by United Kingdom PD Society Brain Bank criteria, having with features of psychosis as diagnosed by the neuropsychiatric inventory (NPI) were included. Patients without a caregiver who could validate the patient's symptoms were excluded.Results:A total of 40 patients (5 women, 35 men) with PD with psychosis (mean age: 54.2 ± 11.5 years, mean duration of illness: 6.5 ± 4.5 years, and mean duration of psychosis: 4.3 ± 4.3 years) were included in the study. The Global NPI score was 19.1 ± 11.5. Majority of the patients had pure hallucinations (85%), while the rest had either pure delusions (7.5%) or a combination of delusions and hallucinations (7.5%). In those with hallucinations, visual hallucinations were the commonest (60%) (pure only in 22.5%), followed by auditory (45%), minor hallucinations (45%), and tactile (20%). Only one person reported having olfactory hallucinations (2.5%). Loss of insight was most often observed during the visual hallucinations (52%), followed by tactile (44.4%), auditory (38.9 %), and minor hallucinations (33.3%).Conclusions:In patients with PD and psychosis, pure hallucinations are common and visual hallucinations are the commonest among the hallucinations. A large proportion of patients have minor hallucinations, which need to be recognized early for effective and early management. The limitations of the study were small sample size, use of a single scale to assess psychosis and subjective assessment of insight.

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Psychosis Assessment in Early-Stage Parkinson’s Disease: Comparing Parkinson’s Psychosis Questionnaire with the Brief Psychiatric Rating Scale in a Portuguese Sample

Cited by 3 publications

References 23 publications

Informant‐ and Self‐Appraisals on the Psychosis and Hallucinations Questionnaire (PsycH‐Q) Enhances Detection of Visual Hallucinations in Parkinson's Disease

Informant‐ and Self‐Appraisals on the Psychosis and Hallucinations Questionnaire (PsycH‐Q) Enhances Detection of Visual Hallucinations in Parkinson's Disease

Parkinson’s Disease Psychosis – Prevalence Patterns Across the EU-5

A clinical profile of patients with Parkinson′s disease and psychosis

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