Psychosis-associated DNA methylomic variation in Alzheimer's disease cortex

Abstract

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Psychosis as a Treatment Target in Dementia: A Roadmap for Designing Interventions

“…only epigenome-wide association study (EWAS) of psychosis in AD conducted to date identified two differentially methylated regions of the genome, located in TBX15 and WT1 which are both implicated in the pathophysiology of AD [124]. Interestingly the top-ranked differentially methylated positions were enriched in known schizophrenia-associated genetic and epigenetic variants, supporting a common mechanism of psychosis.…”

Psychosis in Alzheimer disease — mechanisms, genetics and therapeutic opportunities

“…Study of the epigenome has led to major advances in the understanding of the molecular mechanisms underlying a variety of psychiatric and neurological conditions [71][72][73] . Hypomethylation in the TBX15 and WT1 genes, which have been implicated in the pathophysiology of AD, was found in the dorsolateral prefrontal cortex, superior temporal gyrus and entorhinal cortex in individuals with AD psychosis 74 . Interestingly, and reflecting some of the emerging data from genomic studies, the top-ranked differentially methylated regions also showed enrichment for known schizophrenia-associated genetic and epigenetic variants.…”

Epigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson's disease: A DNA co-methylation network analysis

“…Indeed, several studies have shown robust alterations in DNA methylation in a number of genes in different neurodegenerative diseases, in both the brain and blood, including Alzheimer's disease (AD) [23][24][25] , PD [26][27][28] and Dementia with Lewy bodies (DLB) 29 . Interestingly, associations have also been reported for secondary symptoms of these neurodegenerative disease, for example with psychosis symptoms in AD 30 or cognition in PD 27 . However the analysis of DNA methylation signatures in relation to PD secondary symptoms is understudied and has predominantly been undertaken in peripheral tissues such as blood 31 .…”