Psychosis in epilepsy patients and other chronic medically ill patients and the role of cerebral pathology in the onset of psychosis: A clinical epidemiological study

Feltz-Cornelis, C.M. van der; Aldenkamp, Albert P.; Adèr, H.J.; Boenink, A. D.; Linszen, D.H.; Dyck, Richard van

doi:10.1016/j.seizure.2007.12.004

Cited by 18 publications

(7 citation statements)

References 26 publications

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“…The time periods over which the prevalence rates were calculated were as follows: 27 studies were for an unknown time period, 7 studies were lifetime prevalence studies, 21 studies were for more than 1 year and 3 studies were less than 1 year. Only 6 of the studies had control groups [31-36]. …”

Section: Resultsmentioning

confidence: 99%

“…However, only 4 studies [31,34-36] were used for analysis because two of them [32,33] had no psychosis outcome in the control group so an odds ratio could not be calculated. The pooled odds ratio for risk of psychosis among people with epilepsy was 7.83.…”

Section: Resultsmentioning

confidence: 99%

“…Our finding of 5.6% pooled prevalence of psychosis in epilepsy is lower than estimates of approximately 7% estimates from previous narrative reviews, [18,19] although our finding of 7% for the rate of psychosis in temporal lobe epilepsy is similar. Based on results from population based studies with control samples, [31,34-36] we found that the rate of psychosis among people with epilepsy is 7.8 times higher than in people without epilepsy. However there were very few studies fulfilling these criteria.…”

Section: Discussionmentioning

confidence: 99%

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The prevalence of psychosis in epilepsy; a systematic review and meta-analysis

et al. 2014

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BackgroundEpilepsy has long been considered to be a risk factor for psychosis. However there is a lack of consistency in findings across studies on the effect size of this risk which reflects methodological differences in studies and changing diagnostic classifications within neurology and psychiatry. The aim of this study was to assess the prevalence of psychosis in epilepsy and to estimate the risk of psychosis among individuals with epilepsy compared with controls.MethodsA systematic review and meta-analysis was conducted of all published literature pertaining to prevalence rates of psychosis in epilepsy using electronic databases PUBMED, OVIDMEDLINE, PsychINFO and Embase from their inception until September 2010 with the following search terms: prevalence, incidence, rate, rates, psychosis, schizophrenia, schizophreniform illness, epilepsy, seizures, temporal lobe epilepsy.ResultsThe literature search and search of reference lists yielded 215 papers. Of these, 58 (27%) had data relevant to the review and 157 were excluded following a more detailed assessment. 10% of the included studies were population based studies. The pooled odds ratio for risk of psychosis among people with epilepsy compared with controls was 7.8. The pooled estimate of prevalence of psychosis in epilepsy was found to be 5.6% (95% CI: 4.8-6.4). There was a high level of heterogeneity. The prevalence of psychosis in temporal lobe epilepsy was 7% (95% CI: 4.9-9.1). The prevalence of interictal psychosis in epilepsy was 5.2% (95% CI: 3.3-7.2). The prevalence of postictal psychosis in epilepsy was 2% (95% CI: 1.2-2.8).ConclusionsOur systematic review found that up to 6% of individuals with epilepsy have a co-morbid psychotic illness and that patients have an almost eight fold increased risk of psychosis. The prevalence rate of psychosis is higher in temporal lobe epilepsy (7%). We suggest that further investigation of this association could give clues to the aetiology of psychosis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The prevalence of psychosis in epilepsy; a systematic review and meta-analysis

et al. 2014

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“…[19,20] The hypothesis has been put forward based on the fact that the increased prevalence of autoimmune or chronic inflammatory diseases was before the onset of psychosis. [21] Psychosis is regarded as a well-known symptom in multiple sclerosis (MS), an autoimmune disease, especially in those patients with lesions in the periventricular white matter area. [22] Dickens [23] considered depression was more common in people with chronic inflammatory diseases such as rheumatoid arthritis.…”

Section: Discussionmentioning

confidence: 99%

Umbilical cord blood-based gene signatures related to prenatal major depressive disorder: Retracted

Liu

Zhang

Zheng³

et al. 2019

Medicine

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“…In contrast, the prevalence of POE has been estimated to be between 7% and 10% 1 . A 3-year epidemiological study held in The Netherlands revealed a prevalence of psychosis in 5.6% of epilepsy patients 6 . The overall evidence suggests that schizophrenia-like psychosis is believed to be 6 to 12 times more likely to occur in people with epilepsy than in the general population 7 …”

Section: Epidemiologymentioning

confidence: 99%

Psychosis of epilepsy: a multifaceted neuropsychiatric disorder

Kanner

Rivas-Grajales

2016

CNS Spectr.

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Psychosis of epilepsy (POE) is a term applied to a group of psychotic disorders with a distinct phenomenology in which potential etiopathogenic mechanisms are believed to be closely related to a seizure disorder. POE can present as interictal psychotic episodes, which may often differ semiologically from primary schizophrenic disorder. They may present as ictal or postictal psychotic episodes and may be the expression of an iatrogenic process to pharmacologic and/or surgical interventions.Epilepsy and POE have a complex and bidirectional relation, as not only are patients with epilepsy at greater risk of developing a psychotic disorder, but patients with a primary psychotic disorder are also at greater risk of developing epilepsy. The prevalence of POE is more than 7 times higher than the frequency of primary schizophreniform disorders in the general population. While POE has been associated with focal epilepsy of temporal and frontal lobe origin, its etiology and pathophysiology of POE have yet to be established.The treatment of all forms of POE, with the exception of ictal psychotic episodes, requires the use of antipsychotic drugs, preferably the atypical antipsychotic agents with a very low or negligible potential to lower the seizure threshold (eg, risperidone, apiprazole), starting at a low dose with stepwise increments.

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Psychosis in epilepsy patients and other chronic medically ill patients and the role of cerebral pathology in the onset of psychosis: A clinical epidemiological study

Cited by 18 publications

References 26 publications

The prevalence of psychosis in epilepsy; a systematic review and meta-analysis

The prevalence of psychosis in epilepsy; a systematic review and meta-analysis

Umbilical cord blood-based gene signatures related to prenatal major depressive disorder: Retracted

Psychosis of epilepsy: a multifaceted neuropsychiatric disorder

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