Psychosocial and Neurocognitive Factors Associated With Hepatitis C – Implications for Future Health and Wellbeing

Barreira, David Pires; Marinho, Rui Tato; Bicho, Manuel; Fialho, Renata; Ouakinin, Sílvia

doi:10.3389/fpsyg.2018.02666

Cited by 27 publications

(27 citation statements)

References 58 publications

(74 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to causing hepatic complications, HCV is associated with extrahepatic manifestations, including an increased risk of T2DM, CV disease and neuropsychiatric conditions. [11][12][13][14] The aim of this study was to assess a cohort of patients with HCV to determine the burden of health problems that could be targeted to improve their health and well-being, specifically cardiometabolic risk factors and HRQoL, and to develop a care bundle to improve the holistic care of these patients. One of the most striking findings from this study was that the cohort had a very high estimated CV event risk.…”

Section: Discussionmentioning

confidence: 99%

“…10 This includes neuropsychiatric conditions, such as depression, anxiety and mood disorders. 11 HCV is also an independent risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular (CV) disease, and as a result is associated with an increased risk of early CV-related mortality and all-cause mortality. [12][13][14] Successful treatment of HCV may reduce future risk of CV events and the development of T2DM, 15 16 but even individuals with treated HCV remain at risk of CV complications.…”

Section: Open Accessmentioning

confidence: 99%

See 1 more Smart Citation

Increased cardiovascular risk and reduced quality of life are highly prevalent among individuals with hepatitis C

McPherson¹,

Gosrani

Hogg

et al. 2020

BMJ Open Gastroenterol

View full text Add to dashboard Cite

ObjectiveHepatitis C virus (HCV) infection is common. Although treatment is effective, with oral antivirals curing >95% of patients, most individuals have comorbidities that persist long term. Therefore, our aim was to determine the prevalence of potentially modifiable health problems in patients with HCV and develop an HCV care bundle to identify and target comorbidities.DesignCross-sectional, observational single-centre study that recruited consecutive patients with HCV from our viral hepatitis clinics. Data were collected on cardiovascular (CV) risk factors, lifestyle behaviours, anthropometry and health-related quality of life (HRQoL). QRISK 3 was used to predict 10-year CV event risk.Results100 patients were recruited (67% male, 93% white, median age 52 years (range 24–80); 71% were treated for HCV; 34% had cirrhosis; 14% had diabetes; 61% had hypertension; 31% had metabolic syndrome; and 54% were smokers). The median 10-year CV event risk was 8.3% (range 0.3%–63%). 45% had a predicted 10-year CV event risk of >10%. Only 10% of individuals were treated with statins and 27% with antihypertensives. 92% had a predicted ‘heart age’ greater than their chronological age (median difference +7 (−4 to +26) years). HRQoL was reduced in all SF36v2 domains in the cohort. Factors independently associated with HRQoL included cirrhosis, metabolic syndrome, history of mental health disorder, sedentary behaviour and HCV viraemia.ConclusionA large proportion of patients with HCV presented with increased risk of CV events, and rates of smoking and sedentary behaviour were high, while prescribing of primary prophylaxis was infrequent. HRQoL was also reduced in the cohort. A ‘care bundle’ was developed to provide a structured approach to treating potentially modifiable health problems.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Open Accessmentioning

confidence: 99%

Increased cardiovascular risk and reduced quality of life are highly prevalent among individuals with hepatitis C

McPherson¹,

Gosrani

Hogg

et al. 2020

BMJ Open Gastroenterol

View full text Add to dashboard Cite

show abstract

“…The importance of preventing and treating psychological comorbidities, such as depression and anxiety, can lead to a better quality of life and better overall functioning during treatment. Impairments due to psychological or neurocognitive symptoms are likely to interfere with the way patients experience treatment, in a more or less psychological adjusted way [45]. The use of a personalized and patient-centered approach for these patients, promoting a deeper understanding of disease state and needs, is also desirable [39,46].…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C pretreatment profile and gender differences: Cognition and disease severity effects

Barreira

Marinho

Bicho

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

BACKGROUND The hepatitis C virus (HCV) is known to infect the brain, however findings on associated neuropsychiatric syndrome are controversial and the association itself remains unclear. Gender research in HCV infection is limited, failing to integrate the role of gender in neurocognitive syndrome. This study aimed to characterize psychological and neurocognitive profiles in HCV-infected patients before treatment and to describe gender differences in those profiles as well as the impact of disease severity. METHODS A total of 86 patients diagnosed with chronic hepatitis C were selected in the context of a multidisciplinary out-patient clinic. A semistructured interview was performed to collect social-demographic data and clinical characterization. Assessment was performed using the Hamilton anxiety scale (HAM-A), Hamilton depression scale (HAM-D), Beck depression inventory and a neuropsychological battery to measure attention, concentration, memory and executive functions components validated for the Portuguese population, before starting treatment. To identify the disease severity, platelet ratio index and FibroScan® were used. RESULTS A statistically significant gender effect was found on HAM-A (B = 0.64, confidence interval (CI): 0.17-1.11) and HAM-D, with women scoring higher (B = 0.62, CI: 0.14-1.09) compared to men. Regarding neuropsychological scores, significant differences between gender were identified in executive functions Trails Making Test (TMT)-B (B = 0.48, CI: 0.02-0.97), TMT B-A (B = 0.26, CI: -39.2 to -3.7) and in digit span total (B = -0.52, CI: -1.0 to -0.04), with women performing worse than men. Controlling for years of substance dependence, Digit Span Total was no longer significant; however, TMT-B and TMT B-A continued showing gender differences. Regarding the presence or absence of substance dependence, only HAM-A and HAM-D remained significant. For categorial variables, Digit Span Total was also influenced by gender, with women being more likely to be impaired (odds ratio (OR) = 7.07, CI: 2.04-24.45), and a trend was observed for Digit Span Backward (OR = 3.57, CI: 1.31-9.75). No significant differences were found between disease severity and neurocognitive performance. CONCLUSION Data suggest that gender has an influence on depression, anxiety and cognitive functions independently of the stage of infection. This effect seems influenced by substance dependence.

show abstract

“…For example, patients isolated for MRSA and other infectious diseases showed increased anxiety, stress, depression, and stigmatization as well as decreased self‐esteem and sense of control 48 . These consequences are particularly important because patients with HCV already experience higher rates of depression, anxiety, stigma, and social isolation 51‐53 . Numerous studies discuss the internalized stigma associated with HCV, the role of clinical isolation as an externalized representation of stigma, and the negative health implications of stigma 50,51,54‐57 .…”

Section: Preventionmentioning

confidence: 99%

“…These consequences are particularly important because patients with HCV already experience higher rates of depression, anxiety, stigma, and social isolation 51‐53 . Numerous studies discuss the internalized stigma associated with HCV, the role of clinical isolation as an externalized representation of stigma, and the negative health implications of stigma 50,51,54‐57 . In summary, it is important to weigh the benefits, risks and potentially effective alternatives when addressing the prevention of HCV transmission in HD units.…”

Section: Preventionmentioning

confidence: 99%

Viral hepatitis in patients on hemodialysis

Winston

Wurcel

Gordon

et al. 2020

Seminars in Dialysis

View full text Add to dashboard Cite

Hepatitis B and hepatitis C (HCV) prevalence are higher in people on hemodialysis (HD) than the general population. Through implementation of prevention interventions including vaccines, serologic screening, and post-exposure management, transmissions linked to HD have decreased dramatically. In this manuscript, we review epidemiology of viral hepatitis, summarize current screening and vaccine recommendations, and appraise the available data about efforts to decrease incidence within HD facilities, including isolation of people with viral hepatitis within HD units. Also included is a discussion of the highly effective all-oral HCV treatment options and treatment for HCV in people awaiting kidney transplant.

show abstract

Psychosocial and Neurocognitive Factors Associated With Hepatitis C – Implications for Future Health and Wellbeing

Cited by 27 publications

References 58 publications

Increased cardiovascular risk and reduced quality of life are highly prevalent among individuals with hepatitis C

Increased cardiovascular risk and reduced quality of life are highly prevalent among individuals with hepatitis C

Hepatitis C pretreatment profile and gender differences: Cognition and disease severity effects

Viral hepatitis in patients on hemodialysis

Contact Info

Product

Resources

About