Psychosocial aspects of sports medicine in pediatric athletes: Current concepts in the 21st century

Annual banned‐substance review 16th edition—Analytical approaches in human sports drug testing 2022/2023

“…Here, Derwand et al provided first insights using a rat model, where up to 50 mg of testosterone per kg bodyweight was administered daily for up to 3 weeks, suggesting a ceiling of the dose–response of various organs at daily testosterone dosages of 10 mg/kg 53 . Also blood parameters such as serum erythropoietin (EPO) concentrations and percentage of reticulocytes were corroborated to be affected under supraphysiological AAS use, 54 and health risks observed in humans appear to outreach physical effects, with personality disorders and clinical psychiatric syndromes in males and females having recently been attributed to AAS misuse, too 120–123 …”

“…53 Also blood parameters such as serum erythropoietin (EPO) concentrations and percentage of reticulocytes were corroborated to be affected under supraphysiological AAS use, 54 and health risks observed in humans appear to outreach physical effects, with personality disorders and clinical psychiatric syndromes in males and females having recently been attributed to AAS misuse, too. [120][121][122][123] In the light of the 2021 anti-doping testing figures, where anabolic agents (and in particular AAS) represented 40% of reported AAFs, the extensive efforts that resulted in various publications within the past 12 months (aiming at faster and orthogonal strategies as well as more comprehensive and extended analytical retrospectivity for AAS in sports drug testing) appear warranted. Those efforts focused further on an improved understanding of the metabolism of AAS, the combined T A B L E 1 Overview of prohibited substances and methods of doping according to the World Anti-Doping Agency (WADA) Prohibited List of 2023.…”