Psychosocial determinants of relapse in ulcerative colitis: a longitudinal study

Abstract

After controlling for demographic and clinical variables, more recent stressful events were associated with earlier time to relapse. These findings, which support a biopsychosocial model of disease, might help clinicians identify patients who might benefit from more intensive maintenance medical therapy and behavioral medicine interventions to reduce stress and improve coping.

Psychological aspects of inflammatory bowel disease

“…Thus, studies that are not cohesively designed can lead to confusing results. In UC, Bitton et al 28 reported that the odds ratio of relapse by life events was not very high (1.26 per event). Levenstein et al 27 demonstrated a failure to determine a relationship between life events and relapse.…”

The Relationship Among Perceived Stress, Symptoms, and Inflammation in Persons With Inflammatory Bowel Disease

“…It is also recognized that individuals with IBD who are experiencing symptoms are more likely to have higher levels of perceived stress (8)(9)(10). Perceived stress, which takes into account the perceived controllability, manageability, and personal impact of situations, has a strong and consistent association with concurrent and subsequent IBD symptoms ( 11 ).…”

The Effect of Restraint Stress on the Normal Colon and on Intestinal Inflammation in a Model of Experimental Colitis

“…Bitton et al followed 60 patients with clinically and endoscopically inactive ulcerative colitis prospectively for one year and discovered that the number of important life events was significantly higher in the period preceding exacerbation [1]. Duffy et al have also shown there is a positive temporal association between stress and exacerbation of IBD.…”