Psychosocial difficulties in people with epilepsy: A systematic review of literature from 2005 until 2010

Quintas, Rui; Raggi, Alberto; Giovannetti, Ambra Mara; Pagani, Maria Pia; Sabariego, Carla; Cieza, Alarcos; Leonardi, Matilde

doi:10.1016/j.yebeh.2012.05.016

Cited by 106 publications

(65 citation statements)

References 58 publications

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“…The elevated self-harm risk observed during use of multiple AEDs is likely to be an indication of more severe epilepsy with an associated higher seizure frequency, which is not controlled by AED monotherapy. Furthermore, individuals who have many seizures may experience consequent psychosocial difficulties, including inability to drive or absence from work or social activities, which may exacerbate the stigma associated with epilepsy [26]. Additionally, some individuals may become despondent if AED treatment requires augmentation, despite compliance with monotherapy.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for self-harm in people with epilepsy

et al. 2018

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ObjectiveTo estimate the risk of self-harm in people with epilepsy and identify factors which influence this risk.MethodsWe identified people with incident epilepsy in the Clinical Practice Research Datalink, linked to hospitalization and mortality data, in England (01/01/1998–03/31/2014). In Phase 1, we estimated risk of self-harm among people with epilepsy, versus those without, in a matched cohort study using a stratified Cox proportional hazards model. In Phase 2, we delineated a nested case–control study from the incident epilepsy cohort. People who had self-harmed (cases) were matched with up to 20 controls. From conditional logistic regression models, we estimated relative risk of self-harm associated with mental and physical illness comorbidity, contact with healthcare services and antiepileptic drug (AED) use.ResultsPhase 1 included 11,690 people with epilepsy and 215,569 individuals without. We observed an adjusted hazard ratio of 5.31 (95% CI 4.08–6.89) for self-harm in the first year following epilepsy diagnosis and 3.31 (95% CI 2.85–3.84) in subsequent years. In Phase 2, there were 273 cases and 3790 controls. Elevated self-harm risk was associated with mental illness (OR 4.08, 95% CI 3.06–5.42), multiple general practitioner consultations, treatment with two AEDs versus monotherapy (OR 1.84, 95% CI 1.33–2.55) and AED treatment augmentation (OR 2.12, 95% CI 1.38–3.26).ConclusionPeople with epilepsy have elevated self-harm risk, especially in the first year following diagnosis. Clinicians should adequately monitor these individuals and be especially vigilant to self-harm risk in people with epilepsy and comorbid mental illness, frequent healthcare service contact, those taking multiple AEDs and during treatment augmentation.Electronic supplementary materialThe online version of this article (10.1007/s00415-018-9094-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Risk factors for self-harm in people with epilepsy

et al. 2018

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“…Indeed, the possibility exists that the studies carried out so far have not documented a correlation because patients with TLE have little awareness of their own social difficulties. Therefore, future studies should also use different measures, and not only subjective ones, to quantify the difficulty that patients have in everyday life and possible changes overtime (Quintas et al, 2012).…”

Section: Clinical Relevancementioning

confidence: 99%

Emotion recognition in temporal lobe epilepsy: A systematic review

Monti

Meletti

2015

Neuroscience & Biobehavioral Reviews

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“…It is unclear however the extent to which these difficulties arise from psychosocial conditions or underlying deficits caused by brain lesions. From a psychological perspective, the effects of stigma, role and experience restrictions, effects of parental overprotectiveness and fear of seizures [40,46,47] can all impact on social engagement as well as the ability to learn and practice social knowledge and rules. Taking a neuropsychological perspective, it may be that social difficulties arise due to cognitive impairment, such as reduced information processing speed and capacity, prolonged reaction time, attentional deficits and memory impairments [40], which are common in this population.…”

Section: Understanding Why Difficulties Arise In Social Competence Inmentioning

confidence: 99%

Quality of life is social – Towards an improvement of social abilities in patients with epilepsy

Szemere

Jokeit

2015

Seizure

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Quality of life (QoL) for people with epilepsy is considered worse than the condition's clinical and medical prognosis would predict. Quantity and quality of social interaction considerably determine QoL. Research shows that a significant proportion of patients with epilepsy experience difficulties with social functioning that is thought to be related to impaired QoL. The aim of this review article is to provide an evidence base for conceptualising and developing interventions to improve quality of life through social functioning, for adults with epilepsy. Previous and current research is considered initially with regards to why such difficulties arise and established interventions that address social competence and functioning are reviewed and explored from the field of schizophrenia, a condition also associated with similar difficulties in social cognition, cognition and negative symptoms. The paper considers the advantages and disadvantages of these interventions, the outcomes and emerging research in this area. Positive findings are found from interventional studies in schizophrenia such as the enhancing potential and generalisation of training in social cognition, the benefits of an integrated approach to improving social functioning and proposal of 'online' interaction approaches. These findings provide interesting and exciting directions for the ultimate goal towards interventions for the improvement of social functioning and quality of life in patients with epilepsy. This is of particular significance as at present there is currently no such dedicated program for people with epilepsy.

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Psychosocial difficulties in people with epilepsy: A systematic review of literature from 2005 until 2010

Cited by 106 publications

References 58 publications

Risk factors for self-harm in people with epilepsy

Risk factors for self-harm in people with epilepsy

Emotion recognition in temporal lobe epilepsy: A systematic review

Quality of life is social – Towards an improvement of social abilities in patients with epilepsy

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