Psychosocial effects and clinic reflections of the COVID-19 outbreak in patients with acromegaly and Cushing’s disease

Durcan, Emre; Turan, Şenol; Şahin, Serdar; Sulu, Cem; Taze, Sabriye Sibel; Kavla, Yasin; Özkaya, Hande Mefkure; Kadıoğlu, Pınar

doi:10.1007/s11102-021-01136-5

Cited by 9 publications

(6 citation statements)

References 43 publications

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“…Consistent with previous studies, parents of children with physical illness reported a medium-sized increase in psychological distress from prior to during the COVID-19 pandemic (13,16,19,20,34). This deterioration in the mental health of parents has pervasive sequelae, negatively affecting their well-being (59), and also the health and well-being of their children (60)(61)(62). Psychological distress has been shown to hinder caregiving responsibilities, which can result in poorer health outcomes for children with physical illness (63-65), many of which have complex care needs that may be compounded in the Data are presented as regression coefficient (standard error).…”

Section: Summary Of Findingssupporting

confidence: 84%

COVID-19-Related Psychological and Psychosocial Distress Among Parents and Youth With Physical Illness: A Longitudinal Study

et al. 2021

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Despite the initial thrust of research aimed at understanding the impact of the COVID-19 pandemic on youth with physical illness and their parents, knowledge gaps in the literature remain, providing the impetus for additional investigation. This study described changes in psychological distress from prior to during the COVID-19 pandemic for parents and youth with physical illness, compared parent-proxy and youth self-reported perceptions of COVID-19-related psychosocial health, and modeled factors associated with psychological and psychosocial distress. There were 147 parent–youth dyads (2–16 years) from MY LIFE—a longitudinal study of youth with physical illness. The Kessler-6 (K6) measured psychological distress for the time before the COVID-19 lockdown (December 19 to March 20) and during the pandemic (December 20 to March 21) among parents and youth. COVID-19-related psychosocial health was measured using the CRISIS. Parents and youth reported increases in K6 scores (d = 0.62 and 0.38). Parent-proxy reports on the K6 were lower vs. youth self-reports prior to and during the pandemic (d = 0.63 for both). In contrast, parents reported lower proxy CRISIS scores for worries (d = 0.38) and effects of social restrictions (d = 0.52). Pandemic parent K6 scores were associated with age, combined in-person and online schooling for youth, COVID-19-related worries, and effects of social restrictions. For youth, only COVID-19-related worries and effects of social restrictions were associated with K6 scores. Parent worries were associated with youth sex, parental stress, family functioning, online and combination learning, and social restrictions. Parental depression and worries were associated with effects of social restrictions. Youth worries were associated with online and combination learning, and social restrictions. Youth disability, online learning, and worries were associated with effects of social restrictions. Few clinical factors are associated with COVID-19-related psychological and psychosocial distress. Instead, parent/family factors and youth learning environment have prominent roles in predicting outcomes and have implications for the health, education, and social services systems.

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Section: Summary Of Findingssupporting

confidence: 84%

COVID-19-Related Psychological and Psychosocial Distress Among Parents and Youth With Physical Illness: A Longitudinal Study

et al. 2021

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“…Prevalence of post-traumatic stress disorder was not different in patients with acromegaly vs. Cushing disease vs. healthy controls but higher in SARS-CoV-2 patients; however, frequency of abnormal trait anxiety was significantly higher in patients with acromegaly and SARS-CoV-2 patients vs. those with Cushing disease and healthy controls. Finally, treatment discontinuation rate was higher in acromegaly patients vs. those with Cushing disease [107].…”

Section: Acromegalymentioning

confidence: 87%

“…In another single-centre, cross-sectional, web-based survey psychosocial status of patients with acromegaly and Cushing disease was compared to that of SARS-CoV-2 infected patients and healthy volunteers [107]. Prevalence of post-traumatic stress disorder was not different in patients with acromegaly vs. Cushing disease vs. healthy controls but higher in SARS-CoV-2 patients; however, frequency of abnormal trait anxiety was significantly higher in patients with acromegaly and SARS-CoV-2 patients vs. those with Cushing disease and healthy controls.…”

Section: Acromegalymentioning

confidence: 99%

COVID-19 and the pituitary

et al. 2021

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Background Despite COVID-19 being identified as severe respiratory viral infection, progressively many relevant endocrine manifestations have been reported greatly contributing to the severity of the clinical presentation. Systemic involvement in COVID-19 is due to the ubiquitous expression of angiotensin-converting enzyme 2 (ACE2) receptor, responsible for the entry in the cells of SARS-CoV-2, Several reports in humans and animal models showed a significant ACE2 mRNA expression in hypothalamus and pituitary cells. Moreover, higher mortality and poorer outcomes have been widely described in COVID-19 patients with obesity, diabetes and vertebral fractures, which are all highly prevalent in subjects with pituitary dysfunctions. Aim To review the main endocrine manifestations of COVID-19 with their possible implications for pituitary diseases, the possible direct and indirect involvement of the pituitary gland in COVID-19, the impact of COVID-19 on the management of established pituitary diseases which can be already at increased risk for worse outcomes and on neurosurgical activities as well as vaccination. Conclusions Our review underlines that there could be a specific involvement of the pituitary gland which fits into a progressively shaping endocrine phenotype of COVID-19. Moreover, the care for pituitary diseases need to continue despite the restrictions due to the emergency. Several pituitary diseases, such as hypopituitarism and Cushing disease, or due to frequent comorbidities such as diabetes may be a risk factor for severe COVID-19 in affected patients. There is the urgent need to collect in international multicentric efforts data on all these aspects of the pituitary involvement in the pandemic in order to issue evidence driven recommendations for the management of pituitary patients in the persistent COVID-19 emergency.

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“…Our results on the psychosocial condition of participants may have been modulated when not aggravated during the COVID pandemic, when the study took place. This could be related to the lack of usual followup due to con nement requirements, as reported by different authors [27][28][29]. Thus, we cannot rule out that the con nement caused by the COVID-19 pandemic during the second outbreak in our geographical area may have potentially contributed to an increase in the state of anxiety in acromegalic patients, although we believe that this exceptional situation does not devaluate the results obtained.…”

Section: Discussionmentioning

confidence: 66%

Facial Phenotype Changes and Its Impact in Quality of Life of Acromegaly Patients

Martínez-Momblán

Alonso

Marques

et al. 2022

Preprint

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Purpose: to study the potential relationship between disfiguring facial modifications and psychosocial and Quality of Life (QoL) impact in a group of acromegaly patients. Methods: Thirty patients accepted to participate in this study (n=13) women and 56.6% (n=17) men; mean age was 61.1 ± 15.8 and 56.3 ± 12.4 years, respectively. Variables studied included: a) Anxiety level, measured through the State-Trait Anxiety Questionnaire (STAI); b) Quality of life evaluation by AcroQoL; c) Self-esteem status through the Rosemberg Self-Esteem Scale and d) Facial acromegaly phenotypic changes evaluated from face photographs and scored by 8 trained endocrinologists. Results: Gender differences were observed in Anxiety levels, with higher values in women than in men (trait: 6.1±2.2 and 5.0±2.0 (p=0.025); state: 8.2±1.1 and 3.1±2.1 (p=0.004), respectively. Also, there were differences in the global AcroQoL score, being 69.3 (SD±17.7) for males and 51.1 (SD±21.8) for females (p = 0.004) and it was reflected in all dimensions. Self-Steem was similar in both groups. There were lower values at the face appearance scoring in women at pre-diagnostic phase (3.4±1.3 vs. 4.75±1.5). A negative correlation was found between self-esteem and changes in facial scores at the pre-diagnostic and diagnostic periods (rs= -0.559, p=0.074), consistent with a high impact of facial changes in the psychologic status of the patients. Conclusion: acromegaly facial changes negatively impact the psychosocial condition of these patients with maximal deleterious effects observed at the time of diagnosis; these disturbances persist over time despite disease control or curation and are of higher intensity in women.

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Psychosocial effects and clinic reflections of the COVID-19 outbreak in patients with acromegaly and Cushing’s disease

Cited by 9 publications

References 43 publications

COVID-19-Related Psychological and Psychosocial Distress Among Parents and Youth With Physical Illness: A Longitudinal Study

COVID-19-Related Psychological and Psychosocial Distress Among Parents and Youth With Physical Illness: A Longitudinal Study

COVID-19 and the pituitary

Facial Phenotype Changes and Its Impact in Quality of Life of Acromegaly Patients

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