BackgroundThis prospective study identifies the association between demographic, injury, psychological, and social variables, measured early during recovery, with limitations in function (measured by PROMIS UE) at 6-9 months after distal radius fracture. Additionally, we assessed variables associated with PROMIS UE, QuickDASH, PRWE, EQ-5D-3L over time.
MethodsA total of 364 adult patients (73% female, median age 65 years , IQR 45.5 -77 years) sustaining an isolated distal radius fracture completed questionnaires within 1 week post fracture, between 2-4 weeks, and between 6-9 months after injury. We created a multivariable regression model and Generalized Least Square random effects models, accounting for multicollinearity using correlation matrices, variable inflation factor and partial R 2 .
ResultsMultiple variables within a week of injury correlated with 6-9 month limitations in bivariate analysis. Being retired (Partial R 2 = 0.9, p<0.001), using opioids (Partial R 2 =0.04, p<0.001), using anti-depressants (Partial R 2 =0.11, p<0.001), greater pain interference (Partial R 2 =0.03, p=0.001) and greater pain catastrophization (Partial R 2 =0.04, p<0.002) within a week of injury were strong predictors of greater limitations (PROMIS UE) at 6-9 months in multivariable analysis. Longitudinal analysis of variables over time demonstrated greater pain interference, greater fear of movement, lower self-efficacy, older age and being female as strong predictors of limitations.
ConclusionsRecovery from a distal radius fracture is influenced by a series of demographic, psychological and social variables. Of these factors, being retired, using opioids, using antidepressants, greater pain interference and greater pain catastrophization within a week of injury explain the largest amounts of unique variance in upper extremity physical function. Evaluating the impact of change in variables over time underlined the influence of pain interference as well as the influence of fear of movement and self-efficacy (or resiliency) on limitations in physical function and general health.These findings have important implications for identifying individuals who can benefit from behavioural interventions for these psychological factors to optimize recovery.