Psychosocial factors and immunity in nonhuman primates: a review.

Coe, Christopher L.

doi:10.1097/00006842-199305000-00007

Cited by 111 publications

(53 citation statements)

References 42 publications

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“…Individual differences in cortisol response in such settings have been shown to be reliable (52,53), related to aspects of emotional temperament (49), and modifiable by altering aspects of the social environment (47,88). Possibly related to variations in cortisol responsivity, individual differences in immune reactivity to stressors have also been demonstrated in both human subjects (66) and nonhuman primates (89).…”

Section: Discussionmentioning

confidence: 99%

Adrenocortical and Behavioral Predictors of Immune Responses to Starting School

Adams

et al. 1995

Pediatr Res

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Associations between major psychologic stressors and immune function have been documented in previous research, but few studies have investigated immune changes attending minor, normative stressors. This study examined adrenocortical and behavioral predictors of immune responses to starting kindergarten in 39 five-year-old children, who completed laboratory visits for venipunctures 1 wk before (time 1) and 1 wk after (time 2) school entry. At time 1, children were also immunized with pneumococcal vaccine. Immune responses were measured as change scores for T (CD4+ and CD8+) cells, B (CD19+) cells, lymphoproliferative responses to pokeweed mitogen (PWM), and type-specific pneumococcal antibody responses (ABR). Adrenocortical response was assessed as the change in salivary cortisol level, and behavioral difficulty with school adjustment was scored using parental ratings of behavior problems, stress due to changes in routines, and degree of adaptive challenge. Salivary cortisol rose after lundergarten entry (means = 0.39 ? 0.28 to 0.49 ? 0.36 pg/dL, p = 0.03) and was unrelated to behavioral difficulties. CD4+ cells increased in number, whereas PWM declined, and ~D 1 9 + cells showed a borderline increase. Change in salivary cortisol was positively associated with change in ~~1 9~ (ACD19+) and inversely related to ABR. Scores for behavioral difficulty were inversely associated with A C D~+ and Among the most striking and reliable epidemiologic features of disease in childhood populations is the uneven, nonrandom character of morbidity distributions. Approximately 15-20% of children incur the majority of illness visits in primary care settings and sustain over 50% of the overall population morbidity (1, 2). This maldistribution of pediatric morbidity and

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Section: Discussionmentioning

confidence: 99%

Adrenocortical and Behavioral Predictors of Immune Responses to Starting School

Adams

et al. 1995

Pediatr Res

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“…Even small alterations in species-typical rearing conditions were observed to have adverse long-term impacts on stress physiology and emotionality among nonhuman primates (Gunnar & Quevedo, 2007;Sanchez, 2006 (Levine & Wiener, 1988), ACTH (Clarke & Boinski, 1995), norepinephrine (Higley, Hasert, Suomi, & Linnoila, 1991), and immune response (Boccia, Laudenslager, & Reite, 1995;Coe, 1993;Gorman, Mathew, & Coplan, 2002;Reite, Harbeck, and Hoffman, 1981). Environmental conditions also impact stress physiology.…”

Section: Allostatic Load During Growth a N D De V E L O P Me N Tmentioning

confidence: 99%

Allostatic load and biological anthropology

Edes

Crews

2017

American J Phys Anthropol

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Multiple stressors affect developing and adult organisms, thereby partly structuring their phenotypes. Determining how stressors influence health, well-being, and longevity in human and nonhuman primate populations are major foci within biological anthropology. Although much effort has been devoted to examining responses to multiple environmental and sociocultural stressors, no holistic metric to measure stress-related physiological dysfunction has been widely applied within biological anthropology. Researchers from disciplines outside anthropology are using allostatic load indices (ALIs) to estimate such dysregulation and examine life-long outcomes of stressor exposures, including morbidity and mortality. Following allostasis theory, allostatic load represents accumulated physiological and somatic damage secondary to stressors and senescent processes experienced over the lifespan. ALIs estimate this wear-and-tear using a composite of biomarkers representing neuroendocrine, cardiovascular, metabolic, and immune systems. Across samples, ALIs are associated significantly with multiple individual characteristics (e.g., age, sex, education, DNA variation) of interest within biological anthropology. They also predict future outcomes, including aspects of life history variation (e.g., survival, lifespan), mental and physical health, morbidity and mortality, and likely health disparities between groups, by stressor exposures, ethnicity, occupations, and degree of departure from local indigenous life ways and integration into external and commodified ones. ALIs also may be applied to similar stress-related research areas among nonhuman primates. Given the reports from multiple research endeavors, here we propose ALIs may be useful for assessing stressors, stress responses, and stress-related dysfunction, current and long-term cognitive function, health and well-being, and risk of early mortality across many research programs within biological anthropology. K E Y W O R D Saging, allostasis, frailty, growth and development, nonhuman primates, senescence, stress | I N T R O D U C T I O NTraditional research foci within biological anthropology include variations in stress, morbidity, and mortality (for reviews, see Ice & James, 2007;Little, 2010). Despite this long-term focus, the field continues to pursue a reliable, relatively easy to apply metric for assessing lifetime stress and stress-related outcomes. We suggest incorporating the theory of allostasis and methods for assessing allostatic load within anthropological theory and methodology to aid in closing this gap. As a theory, allostasis was developed to explain how mammalian physiological responses to stressors in their environments evolved to maximize the probability of survival while limiting somatic damage (Korte, Koolhaas, Wingfield, & McEwen, 2005;McEwen & Stellar, 1993;McEwen & Wingfield, 2003;Sterling, 2004Sterling, , 2012Sterling & Eyer, 1988). Unfortunately, such beneficial defensive responses come at a cost and, over time, repeated allostatic activi...

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“…This situation is particularly true for the subjects of our research, young adult male monkeys, for which intergroup transfers are normal, but highly stressful, features of their life history (12,13). Considerable data from nonhuman primates indicate that social instability can result in alterations in hypothalamic-pituitary-adrenal (HPA) hormone concentrations and immune function (14)(15)(16)(17). In the present study, we hypothesized that instability in rhesus monkey social groups would have implications for immunodeficiency disease progression as well.…”

mentioning

confidence: 91%

Social stress results in altered glucocorticoid regulation and shorter survival in simian acquired immune deficiency syndrome

Capitanio

Mendoza

Lerche

et al. 1998

Proc. Natl. Acad. Sci. U.S.A.

166

116

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From early in the AIDS epidemic, psychosocial stressors have been proposed as contributors to the variation in disease course. To test this hypothesis, rhesus macaques were assigned to stable or unstable social conditions and were inoculated with the simian immunodeficiency virus. Animals in the unstable condition displayed more agonism and less affiliation, shorter survival, and lower basal concentrations of plasma cortisol compared with stable animals. Early after inoculation, but before the emergence of group differences in cortisol levels, animals receiving social threats had higher concentrations of simian immunodeficiency virus RNA in plasma, and those engaging in affiliation had lower concentrations. The results indicate that social factors can have a significant impact on the course of immunodeficiency disease. Socially induced changes in pituitaryadrenal hormones may be one mechanism mediating this relationship.

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Psychosocial factors and immunity in nonhuman primates: a review.

Cited by 111 publications

References 42 publications

Adrenocortical and Behavioral Predictors of Immune Responses to Starting School

Adrenocortical and Behavioral Predictors of Immune Responses to Starting School

Allostatic load and biological anthropology

Social stress results in altered glucocorticoid regulation and shorter survival in simian acquired immune deficiency syndrome

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