Psychosocial Factors Predict COVID-19 Vaccine Side Effects

Geers, Andrew L.; Clemens, Kelly S.; Faasse, Kate; Colagiuri, Ben; Webster, Rebecca; Vase, Lene; Sieg, Mette; Jason, E Chan; Colloca, Luana

doi:10.1159/000519853

Cited by 31 publications

(45 citation statements)

References 9 publications

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“…This issue was assessed in the present research via secondary data analyses of a prospective longitudinal study of a US national sample [ 23 ]. We tested the hypothesis that booster intentions are related to the total number of side effects reported, the intensity of side effects reported, as well as if the participant reported experiencing an intense side effect from the primary COVID-19 vaccine.…”

Section: Introductionmentioning

confidence: 99%

Do Side Effects to the Primary COVID-19 Vaccine Reduce Intentions for a COVID-19 Vaccine Booster?

Geers

Clemens

Colagiuri

et al. 2022

Annals of Behavioral Medicine

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Background Vaccines are being administered worldwide to combat the COVID-19 pandemic. Vaccine boosters are essential for maintaining immunity and protecting against virus variants. The side effects of the primary COVID-19 vaccine (e.g., headache, nausea), however, could reduce intentions to repeat the vaccination experience, thereby hindering global inoculation efforts. Purpose The aim of this research was to test whether side effects of a primary COVID-19 vaccine relate to reduced intentions to receive a COVID-19 booster. The secondary aim was to test whether psychological and demographic factors predict booster intentions. Methods Secondary data analyses were conducted on a U.S. national sample of 551 individuals recruited through the online platform Prolific. Key measures in the dataset were side effects reported from a primary COVID-19 vaccination and subsequent intentions to receive a booster vaccine. Psychological and demographic variables that predicted primary vaccination intentions in prior studies were also measured. Results Booster intentions were high. COVID-19 booster vaccine intentions were uncorrelated with the number of side effects, intensity of side effects, or occurrence of an intense side effect from the primary COVID-19 vaccine. Correlational and regression analyses indicated intentions for a booster vaccination increased with positive vaccination attitudes, trust in vaccine development, worry about the COVID-19 pandemic, low concern over vaccine side effects, and democratic political party affiliation. Conclusions Side effects of a primary COVID-19 vaccine were not directly associated with lower intentions to receive a booster of the COVID-19 vaccine early in the pandemic. However, many variables that predict primary vaccination intentions also predict booster intentions.

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Section: Introductionmentioning

confidence: 99%

Do Side Effects to the Primary COVID-19 Vaccine Reduce Intentions for a COVID-19 Vaccine Booster?

Geers

Clemens

Colagiuri

et al. 2022

Annals of Behavioral Medicine

Self Cite

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“…Similarly, those who reported that they knew someone who had been seriously ill or died from COVID-19 were less likely to report a side effect. A recent study in the United States found that pre-vaccine side effect expectations, worry about COVID-19 and depressive symptoms predicted reported COVID-19 vaccine side effects 28 . This is consistent with our findings showing that psychological factors may influence reported adverse events.…”

Section: Discussionmentioning

confidence: 99%

“…At first follow up 487 (51.6%) and at second follow up 482 (52.3%) participants were female. The median age was 30 years IQR (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39). For all three interviews, approximately 12.6% of participants were people living with HIV (PLWH).…”

Section: Demographic Characteristicsmentioning

confidence: 99%

Vaccine Side Effects Following COVID-19 Vaccination with Inactivated Vaccines in Zimbabwe

Makadzange¹,

Gundidza²,

Lau³

et al. 2022

Preprint

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Vaccination is one of the most effective methods for preventing morbidity and mortality from COVID-19. Vaccine hesitancy has led to a decrease in vaccine uptake; driven by misinformation, fear, and perceptions of vaccine safety. Whole inactivated vaccines have been used in one-fifth of the vaccine recipients in Africa, however there is limited real-world data on their safety. We evaluated the reported side effects and factors associated with reported side effects following vaccination with whole inactivated COVID-19 vaccines - BBiBP-CorV (Sinopharm) and CoronaVac (Sinovac). A quantitative survey evaluating attitudes and side effects from vaccination was administered to 1016 adults presenting at vaccination centers. Two follow-up telephone interviews were conducted to determine side effects after the first and second vaccination dose. Overall, the vaccine was well tolerated; 26.0% and 14.4% reported side effects after the first and second dose respectively. The most frequent local and systemic side effects were pain at the injection site and headaches respectively. Most symptoms were mild, and no participants re-quired hospitalization. Participants who perceived COVID-19 vaccines as safe or had a personal COVID-19 experience were significantly less likely to report side effects. Our findings provide data on the safety and tolerability of whole inactivated COVID-19 vaccines in an African population, providing the necessary data to create effective strategies to increase vaccination and support vaccination campaigns.

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Section: Introductionmentioning

confidence: 99%

“…15 One study, investigating other psychological variables, found evidence for an association between COVID-19 vaccine side-effect reports and higher side-effect expectations, greater worry about COVID-19, and depressive symptoms. 16 At the start of the COVID-19 vaccine rollout in the UK (January 2021), we conducted an online crosssectional survey investigating perceptions about COVID-19 and vaccination, vaccination intention and side-effect expectations. 17 We found that only 9% of participants thought that side effects were likely (58% judged them uncertain, 33% judged them unlikely), while clinical trial data indicated that rates experienced were substantially higher (injection-site symptoms up to 89%, non-injection-site symptoms up to 70%).…”

Section: Introductionmentioning

confidence: 99%

Psychological factors associated with reporting side effects following COVID-19 vaccination: a prospective cohort study (CoVAccS – wave 3)

Smith

Sim

Sherman

et al. 2022

Preprint

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Objective: To investigate symptom reporting following the first and second COVID-19 vaccine doses, attribution of symptoms to the vaccine, and factors associated with symptom reporting. Methods: Prospective cohort study (T1: 13-15 January 2021, T2: 4-15 October 2021). Participants were aged 18 years or older, living in the UK. Personal, clinical, and psychological factors were investigated at T1. Symptoms were reported at T2. We used logistic regression analyses to investigate associations. Results: After the first COVID-19 vaccine dose, 74.1% (95% CI 71.4% to 76.7%, n=762/1028) of participants reported at least one injection-site symptom, while 65.0% (95% CI 62.0% to 67.9%, n=669/1029) reported at least one other (non-injection-site) symptom. Symptom reporting was associated with being a woman and younger. After the second dose, 52.9% (95% CI 49.8% to 56.0%, n=532/1005) of participants reported at least one injection-site symptom and 43.7% (95% CI 40.7% to 46.8%, n=440/1006) reported at least one other (non-injection-site) symptom. Symptom reporting was associated with having reported symptoms after the first dose, having an illness that put one at higher risk of COVID-19 (non-injection-site symptoms only), and not believing that one had enough information about COVID-19 to make an informed decision about vaccination (injection-site symptoms only). Conclusions: Women and younger people were more likely to report symptoms from vaccination. People who had reported symptoms from previous doses were also more likely to report symptoms subsequently, although symptom reporting following the second vaccine was lower than following the first vaccine. Few psychological factors were associated with symptom reporting.

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Psychosocial Factors Predict COVID-19 Vaccine Side Effects

Cited by 31 publications

References 9 publications

Do Side Effects to the Primary COVID-19 Vaccine Reduce Intentions for a COVID-19 Vaccine Booster?

Do Side Effects to the Primary COVID-19 Vaccine Reduce Intentions for a COVID-19 Vaccine Booster?

Vaccine Side Effects Following COVID-19 Vaccination with Inactivated Vaccines in Zimbabwe

Psychological factors associated with reporting side effects following COVID-19 vaccination: a prospective cohort study (CoVAccS – wave 3)

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