Psychosocial interventions for benzodiazepine harmful use, abuse or dependence

Darker, Catherine; Sweeney, Brion; Barry, Joe; Farrell, Michael; Donnelly‐Swift, Erica

doi:10.1002/14651858.cd009652.pub2

Cited by 90 publications

(92 citation statements)

References 85 publications

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“…Finally, screening and brief motivational interviewing-based interventions that promote appropriate medication use should be considered, as they can lower opioid PDM risk and can be delivered by non-prescribers (Chang, Compton, Almeter, & Fox, 2015). More significant interventions may be needed (e.g., cognitive-behavioral therapy; Darker, Sweeney, Barry, Farrell, & Donnelly-Swift, 2015) for those with signs of PDM (e.g., early refill requests).…”

Section: Discussionmentioning

confidence: 99%

Prescription tranquilizer/sedative misuse prevalence and correlates across age cohorts in the US

Schepis

Teter

Simoni

et al. 2018

Addictive Behaviors

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This work highlighted young adults and those with other substance use as most likely to engage in tranquilizer/sedative misuse. In particular, those endorsing suicidality and reporting opioid misuse are a subgroup of concern, given their especially elevated rates of misuse and the increased risk for overdose imparted by tranquilizer/sedative medication. Workplace-based interventions for young adults and school-based universal prevention may be warranted to limit tranquilizer/sedative misuse in these groups.

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Section: Discussionmentioning

confidence: 99%

Prescription tranquilizer/sedative misuse prevalence and correlates across age cohorts in the US

Schepis

Teter

Simoni

et al. 2018

Addictive Behaviors

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“…Secondly, GPs could play a key role in limiting BZDs misuse, abuse or dependence, as shown in a recent report highlighting the active involvement of GPs, particularly for educating their patients to cease or reduce BZD use, in order to decrease BZD consumption (Darker et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Does initial use of benzodiazepines delay an adequate pharmacological treatment? A multicentre analysis in patients with psychotic and affective disorders

Grancini

Carlo

Palazzo

et al. 2018

International Clinical Psychopharmacology

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It is established that delayed effective pharmacotherapy plays a significant role in the overall burden of psychiatric disorders, which are often treated with symptomatic drugs, that is benzodiazepines (BZDs), in relation to their rapid onset of action and safety, despite long-term side effects. We aimed to assess the influence of initial treatment with BZDs on the duration of untreated illness (DUI) and whether specific sociodemographic and clinical factors could influence the choice of BZDs as first treatment in 545 patients affected by schizophrenia, mood and anxiety spectrum disorders. Statistical analyses (one-way analysis of variance and χ) were carried out to compare patients who used BZDs as first treatment (BZD w/) and those who did not (BZD w/o). The overall DUI, irrespective of diagnosis, resulted in significantly longer in BZD w/ versus w/o patients, who also experienced more frequently anxious/depressive symptoms at onset. Furthermore, BZD w/ patients more frequently autonomously decided to look for treatment (mainly refering to psychologists or general practitioners) and experimented more frequently phobias, than BZD w/o ones. The present findings suggest that initial BZDs treatment may prolong the overall DUI, although their prescription seems to be influenced by specific sociodemographic and clinical factors. Further studies are needed to confirm the present findings.

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“…Finally, appropriate treatment strategies for BZD users must also be given priority. This might involve a controlled tapering of prescribed BZDs, or a more intensely supervised detoxification for patients with complicated comorbidities (Ashton 1994, Lader, Tylee et al 2009, Darker, Sweeney et al 2015). …”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with benzodiazepine use among people who inject drugs in an urban Canadian setting

Tucker

Hayashi

Milloy

et al. 2016

Addictive Behaviors

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Background Though known to have abuse potential, benzodiazepine medications remain widely prescribed. Furthermore, issues related to benzodiazepine use by people who inject drugs (PWID) remain to be fully characterized. We therefore sought to examine the prevalence of and risk factors associated with benzodiazepine use in a street-involved urban population. Methods Between May 1996 and November 2013, data were derived from two open prospective cohort studies in Vancouver, Canada, restricted to PWID. Multivariable logistic regression with generalized estimating equations (GEE) was used to determine factors independently associated with benzodiazepine use. Results Over the study period, 2806 individuals were recruited, including 949 (34%) women. Of these, 1080 (38.5%) participants reported benzodiazepine use at least once during the study period. In the multivariable analysis, Caucasian ethnicity, ≥ daily heroin injection, ≥ daily cocaine injection, non-fatal overdose, incarceration, syringe sharing, and unsafe sex were all independently associated with benzodiazepine use. Conversely, older age, homelessness, and ≥ daily crack smoking were negatively associated with benzodiazepine use. Conclusions Use of benzodiazepines was common in this urban setting and was associated with several markers of addiction severity and significant health and social vulnerabilities including syringe sharing and unsafe sex. These findings underscore the need to promote treatment for benzodiazepine use, safer benzodiazepine prescribing, including greater recognition of the limited indications for evidence-based use of this medication class.

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Psychosocial interventions for benzodiazepine harmful use, abuse or dependence

Cited by 90 publications

References 85 publications

Prescription tranquilizer/sedative misuse prevalence and correlates across age cohorts in the US

Prescription tranquilizer/sedative misuse prevalence and correlates across age cohorts in the US

Does initial use of benzodiazepines delay an adequate pharmacological treatment? A multicentre analysis in patients with psychotic and affective disorders

Risk factors associated with benzodiazepine use among people who inject drugs in an urban Canadian setting

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