Psychosocial outcome in adult men born with hypospadias

Örtqvist, Lisa; Andersson, Marcus; Strandqvist, Anna; Nordenström, Anna; Frisén, Louise; Holmdahl, Gundela; Nordenskjöld, Agneta

doi:10.1016/j.jpurol.2016.08.008

Cited by 27 publications

(20 citation statements)

References 16 publications

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“…This showed decreased satisfaction with the cosmetic results and increased urological problems, when compared with controls, but no impairments with respect to quality of life and only minor differences in psychosocial outcome. Sexual function and fertility were comparable, but impaired in the group with proximal hypospadias .…”

Section: Introductionmentioning

confidence: 80%

Psychiatric symptoms in men with hypospadias – preliminary results of a cross‐sectional cohort study

et al. 2018

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Aim: Population studies have shown an increased risk of neurodevelopmental disorders in males born with the congenital condition hypospadias, where the opening of the urethra is on the underside of the penis. We investigated overall psychiatric morbidity in cases and matched controls.Methods: This study compared 167 men born with hypospadias from 1959 to 1994 in Stockholm or Gothenburg in Sweden using hospital registers. They were compared with controls from the Swedish population registry, who were contacted by regular mail and students who were recruited by local advertisements. The total sample had a mean age of 33.5 years (range: 19-54). They completed self-rating scales for depressive, anxiety and obsessive-compulsive symptoms and symptoms of attention deficit hyperactivity disorder. In addition, 33 cases and 47 controls underwent psychiatric morbidity interviews that covered the 17 most common psychiatric diagnoses.Results: A fifth (21%) of both the cases and controls reported current or previous psychiatric symptoms. There were no significant differences in self-rated depression, anxiety or obsessive-compulsive disorder symptoms between the patients and controls or between the different phenotype groups. The distribution was not significantly affected by the severity of hypospadias.Conclusion: Psychiatric morbidity was no higher in men with hypospadias than populationbased controls.€ Ortqvist et al.Psychiatric health and hypospadias

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Section: Introductionmentioning

confidence: 80%

Psychiatric symptoms in men with hypospadias – preliminary results of a cross‐sectional cohort study

et al. 2018

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“…Reports have stated that men with 46,XY DSD are less often in intimate relationships compared to controls, but more often than women with 46,XY DSD (Lee et al, 2012). Reasons reported for not considering marriage were fear of rejection because of infertility and a small penis (Gupta, Bhardwaj, Sharma, Ammini, & Gupta, 2010;Ortqvist et al, 2017). Men after hypospadias repair were similarly sexually active but are less satisfied compared to controls (Rynja, de Jong, Bosch, & de Kort, 2011).…”

Section: Introductionmentioning

confidence: 99%

Sexuality in Adults with Differences/Disorders of Sex Development (DSD): Findings from the dsd-LIFE Study

Kreukels

Cohen‐Kettenis

Roehle

et al. 2019

Journal of Sex & Marital Therapy

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For various reasons, sexuality of individuals with differences/disorders of sex development (DSD) may be affected. The aim of the study was to describe sexual activity, satisfaction with sex life, satisfaction with genital function, and sexual problems in people with different DSD conditions. Data were collected from 1,040 participants in Europe. Many people with a variety of DSD conditions do not appear to be satisfied with their sex life, experience a variety of sexual problems, and are less sexually active than the general population; therefore sexuality should be explicitly addressed in the care of people with DSD.

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“…Data on education, income, and marriage/partnership from both register studies and clinical follow-up show no differences compared with controls. 19 20 Furthermore, men with hypospadias do not seem to have more psychiatric symptoms or cognitive dysfunctions than controls. 21 22…”

Section: Outcomes In a Long-term Perspectivementioning

confidence: 96%

“…There is an interest for more psychological support and peer support, especially in males born with severe hypospadias, and especially during adolescence. 20 28 29 A national register-based study has shown a higher risk for neurodevelopmental disorders, like intellectual disability, autism spectrum disorders, attention deficit, and hyperactivity disorder, in men with hypospadias compared with controls. In part, this is probably due to the common risk factor of low birth weight.…”

Section: Outcomes In a Long-term Perspectivementioning

confidence: 99%

Role of Genetic Counseling for Patients with Hypospadias and Their Families

Nordenskjöld

Holmdahl

2021

Eur J Pediatr Surg

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Congenital malformations often have a genetic background associated with a recurrence risk and may be part of a syndrome. Therefore, for children with a congenital malformation, the parents should be offered genetic counseling, and the child should also be offered the same when they reach adulthood. Hypospadias is a common malformation in boys that arises during genital development in weeks 8 to 16. This results in an underdevelopment of the ventral aspect of the penis with a misplacement of the urethral opening somewhere along the penis, scrotum, or in the perineum and with different degrees of penile curvature. The cause can be monogenic, but generally it is regarded as a complex disorder caused by both genetic and environmental factors. Severe hypospadias and familial cases should be genetically investigated, as for other forms of disorders of sex development, according to current guidelines with sequencing of relevant genes. Hypospadias associated with another independent malformation may be part of a syndrome and should be investigated. Fortunately, boys born with milder hypospadias generally have a good outcome and thus the clinical value of finding a disease-causing mutation appears to be limited especially in light of the present cost of genetic analysis. However, all men born with hypospadias should be advised on the recurrence risk and risk for reduced fertility.

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Psychosocial outcome in adult men born with hypospadias

Cited by 27 publications

References 16 publications

Psychiatric symptoms in men with hypospadias – preliminary results of a cross‐sectional cohort study

Psychiatric symptoms in men with hypospadias – preliminary results of a cross‐sectional cohort study

Sexuality in Adults with Differences/Disorders of Sex Development (DSD): Findings from the dsd-LIFE Study

Role of Genetic Counseling for Patients with Hypospadias and Their Families

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