Psychosocial Phenotyping in Women With Interstitial Cystitis/Painful Bladder Syndrome: A Case Control Study

Nickel, J. Curtis; Tripp, Dean A.; Pontari, Michel A.; Moldwin, Robert; Mayer, Robert; Carr, Lesley K.; Doggweiler, Raggi; Yang, Claire C.; Mishra, Nagendra; Nordling, Jørgen

doi:10.1016/j.juro.2009.08.133

Cited by 133 publications

(125 citation statements)

References 18 publications

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“…8 While our large wellmatched case-control study did show a higher prevalence of sexual abuse prior to age 17 in IC/BPS patients (24.0%) compared to asymptomatic control subjects (14.7%), the difference in our collective sample only reached modest statistical significance (p = 0.047). Patients reporting childhood sexual abuse reported more pain, depression and poorer quality of life than patients not reporting such abuse.…”

Section: Discussioncontrasting

confidence: 57%

“…Patient populations and recruitment strategies for this case-control childhood sexual trauma and ic/BPs questionnaire-based study have been previously published. 8 Following initial contact (phone, personal contact or letter), interested IC/BPS patients and control subjects were mailed a package containing two copies of the informed consent (specific Institutional Review Board-approved consent for patients and control participants) and the packet of questionnaires. Patients and control subjects were asked to return a signed copy of the informed consent, as well as a completed set of questionnaires.…”

Section: Subjects and Study Designmentioning

confidence: 99%

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Childhood sexual trauma in women with interstitial cystitis/bladder pain syndrome: a case control study

Nickel

Tripp

Pontari

et al. 2013

CUAJ

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Background: The impact of early lifetime trauma on symptom severity and quality of life of patients with interstitial cystitis/bladder pain syndrome (IC/BPS) has not been fully elucidated. We wanted to determine and compare the prevalence and impact of childhood traumatic events, with an emphasis on childhood sexual abuse, on patient symptoms, quality of life and other biopsychosocial parameters. Methods: Subjects (female patients with IC/BPS and controls without IC/BPS) completed psychosocial phenotyping questionnaires, including a demographics/history form, and validated questionnaires focused on presenting symptoms (IC symptom indices, pain), psychosocial parameters (depression, anxiety, pain catastrophizing, sexual functioning, social support) and quality of life. Participants also completed the Childhood Traumatic Events Scale. Results: Questionnaires were completed by 207 IC/BPS patients and 117 controls matched for age, partner status and education. It was found that before 17 years of age, the IC/BPS cases reported higher prevalence of "raped or molested" compared to controls (24.0% vs. 14.7%; p = 0.047). Within the IC/BPS group, cases reporting previous sexual abuse endorsed greater sensory pain, depression and poorer physical quality of life at the present time compared to IC cases without a sexual abuse history. In the controls only, those reporting previous sexual abuse endorsed more depression, anxiety, stress, social maladjustment poorer mental quality of life in the present time. When the analysis was corrected for potential multiple comparison error, none of the findings remained significant in either the IC/BPS or control groups. Interpretation: Childhood traumatic events, in particular sexual abuse and extreme illness, are reported as more common in IC/ BPS patients than controls. Early trauma, such as the occurrence of sexual abuse, is associated with some differences in patient adjustment (e.g., pain, quality of life, depression) but this impact appears to be, at most, very modest.

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Section: Discussioncontrasting

confidence: 57%

Section: Subjects and Study Designmentioning

confidence: 99%

Childhood sexual trauma in women with interstitial cystitis/bladder pain syndrome: a case control study

Nickel

Tripp

Pontari

et al. 2013

CUAJ

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“…1 Androgen-deprivation therapy (ADT) remains a cornerstone of management of advanced disease; ADT improves survival when used in combination with radiotherapy in men with high-risk localized cancer, and represents standard palliation for men with incurable disease. [2][3][4] Despite the cancer-related benefits, ADT has been well-shown to be associated with short-and long-term adverse effects, including sexual dysfunction, fatigue, hot flashes, osteoporosis, and cardiovascular complications. 5 There is increasing evidence that ADT may also impact the psychological well-being of prostate cancer patients; 6,7 however, there are conflicting results in the literature as to the impact of ADT on depression.…”

Section: Introductionmentioning

confidence: 99%

Biopsychosocial impact of prostate cancer and androgen-deprivation therapy

Tripp

Verreault²,

Tong

et al. 2017

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Introduction: Prostate cancer is the most non-cutaneous malignancy in men, and androgen-deprivation therapy (ADT) is a cornerstone of management in advanced disease. The aim of this study was to evaluate the association of ADT with changes in depression and mental and physical quality of life (QoL) within a prospective patient cohort design. Methods: Patients were prospectively recruited and consented at a single academic health sciences centre in Ontario, Canada. Inclusion criteria included those men with adenocarcinoma of the prostate and either on watchful waiting or initiating ADT as palliation or as an adjuvant therapy for high-risk localized disease. All three cohorts were followed in routine care and completed psychosocial evaluations, including depression, social support, anxiety, and QoL measures. Results: In comparison to the control cohort of patients with prostate cancer on watchful waiting, initiation of ADT over a two-year period of time was not associated with any changes in depression or mental QoL. Instead, all patients, regardless of treatment cohort, showed increased depression scores and reduced mental QoL scores over time; however, for patients receiving ADT, a significant reduction in physical QoL compared to patients who did not receive ADT was demonstrated. Conclusions: ADT does not appear to significantly impact depressive symptoms and mental QoL over a two-year period; however, the depressive symptoms in this limited sample of men with prostate cancer was higher than expected and monitoring for these may be advisable for those who care for such patients. IntroductionProstate cancer is the most common non-cutaneous malignancy and the second leading cause of cancer-related death of men in North America.1 Androgen-deprivation therapy (ADT) remains a cornerstone of management of advanced disease; ADT improves survival when used in combination with radiotherapy in men with high-risk localized cancer, and represents standard palliation for men with incurable disease.2-4 Despite the cancer-related benefits, ADT has been well-shown to be associated with short-and long-term adverse effects, including sexual dysfunction, fatigue, hot flashes, osteoporosis, and cardiovascular complications.5 There is increasing evidence that ADT may also impact the psychological well-being of prostate cancer patients; 6,7 however, there are conflicting results in the literature as to the impact of ADT on depression. Many studies that have implicated ADT in depression either did not use validated depression-specific questionnaires or did not include control groups with patients suffering from prostate cancer and not receiving treatment. Thus, we sought to determine the impact of ADT on depression and mental and physical quality of life (QoL) in patients with both local and advanced disease using a prospective cohort study. We also wanted to determine the predictors of mental and physical QoL in men with prostate cancer. Methods ParticipantsParticipants were recruited from a single academic health sciences c...

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“…Therefore, effective management of IC/ BPS has not been established yet, and IC/BPS symptoms still result in a poor quality of life with sleep disruption, depression, and sexual dysfunction. [7][8][9] In addition, increased excitability of bladder afferent pathways has been proposed as a potential pathophysiological mechanism not only of hypersensitive bladder disorders such as IC/BPS, [10][11][12][13] but also of overactive bladder (OAB). 14 It has also been reported that the transient receptor potential vanilloid-1 (TRPV1) receptor, predominantly expressed in C-fiber afferent pathways, greatly contributes to afferent sensitization in chronic pain conditions.…”

Section: Introductionmentioning

confidence: 99%

Herpes Simplex Virus Vector-Mediated Gene Delivery of Poreless TRPV1 Channels Reduces Bladder Overactivity and Nociception in Rats

et al. 2015

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Increased afferent excitability has been proposed as an important pathophysiology of interstitial cystitis/ bladder pain syndrome (IC/BPS) and overactive bladder (OAB). In this study, we investigated whether herpes simplex virus (HSV) vectors encoding poreless TRPV1, in which the segment in C terminus of TRPV1 receptor is deleted, suppress bladder overactivity and pain behavior using a rat model of chemical cystitis. Replication-defective HSV vectors encoding poreless TRPV1 were injected into the bladder wall of adult female Sprague-Dawley rats. Additionally, recombinant HSV virus (vHG) vectors were injected as control. Cystometry (CMG) under urethane anesthesia was performed 1 week after viral injection to evaluate bladder overactivity induced by resiniferatoxin (RTx, a TRPV1 agonist). RTx-induced nociceptive behavior such as licking (lower abdominal licking) and freezing (motionless head-turning) was observed 2 weeks after viral injection. GFP expression in L4/L6/S1 dorsal root ganglia and the bladder as well as cFos-positive cells in the L6 spinal cord dorsal horn were also evaluated 2 weeks after viral injection. In CMG, the poreless TRPV1 vector-treated group showed a significantly smaller reduction in intercontraction intervals and voided volume after RTx infusion than the vHG-treated control group. The number of the RTx-induced freezing events was significantly decreased in the poreless TRPV1 group than in the vHG group, whereas there was no significant difference of the number of RTx-induced licking events between groups. The number of c-Fos-positive cells in the DCM and SPN regions of the L6 spinal dorsal horn was significantly smaller in the poreless TRPV1 group than in the vHG group. Our results indicated that HSV vector-mediated gene delivery of poreless TRPV1 had a therapeutic effect on TRPV1-mediated bladder overactivity and pain behavior. Thus, the HSV vector-mediated gene therapy targeting TRPV1 receptors could be a novel modality for the treatment of OAB and/or hypersensitive bladder disorders such as IC/BPS.

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Psychosocial Phenotyping in Women With Interstitial Cystitis/Painful Bladder Syndrome: A Case Control Study

Abstract: Patients with interstitial cystitis/painful bladder syndrome have significant cognitive and psychosocial alterations compared to controls.

Cited by 133 publications

References 18 publications

Childhood sexual trauma in women with interstitial cystitis/bladder pain syndrome: a case control study

Childhood sexual trauma in women with interstitial cystitis/bladder pain syndrome: a case control study

Biopsychosocial impact of prostate cancer and androgen-deprivation therapy

Herpes Simplex Virus Vector-Mediated Gene Delivery of Poreless TRPV1 Channels Reduces Bladder Overactivity and Nociception in Rats

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