Psychosocial profile and psychiatric morbidity among Egyptian patients after living donor liver transplantation

Abstract

Background: Living donor liver transplantation is an effective line of therapy for patients with end-stage liver disease. While there are various psychiatric complications that affect donors, only a few studies investigated such complications among Egyptian living donors. Results: The study showed psychiatric morbidity in 15% of donors, especially anxiety disorders and major depression. Donors had high mean scores on psychoticism, neuroticism, impulsivity, and extraversion subscales of the EPQ. Female gender, younger age group, low educational level, managerial work, being the sibs of the recipients, and obtaining high scores in the EPQ were found to be independent risk factors correlated with the development of psychiatric morbidity in liver donors. Conclusion: The increased frequency of psychiatric morbidity among liver donors raises the need for thorough pre-and postoperative psychiatric assessment and monitoring. It is mandatory to investigate the donors' personality traits preoperatively to assess the decision-making process for donation and postoperatively to plan appropriate protective and treatment programs.

Does pre‐operative counselling of the donor improve immediate and short‐term outcomes after living liver donation? – A review of the literature and expert panel recommendations

“…Screening of 452 record and full texts led to 12 articles matching inclusion criteria. All of the 12 included works were comparative studies, of which one was a randomized controlled trial (RCT), 13 and 11 were observational retrospective cohort studies 14–25 . Across the 12 included studies, a total of 933 individuals undergoing donor hepatectomy were included in these manuscripts, only 90 received dedicated perioperative ERAS protocols.…”

“…Pre-donation psychological factors were associated with elevated rates of post-donation anxiety and depression, or poorer coping. These factors included neuroticism (p < 0.001), extraversion and impulsivity (p < 0.001), 14 negative selfimage, 24 and poor pre-operative emotional coping (anxiety). 22 Donor's state anxiety (STAI-S) did not change from pre-donation to immediate or short term follow up, 23 but pre-donation state anxiety (STAI-S) diminished significantly (p = 0.0027) at long term follow up assessment.…”

A meta‐analysis on the incidence of donor‐related depression after liver transplant

“…1). There were five included studies from United States [6,21,22,28,46], three each from Taiwan [8,25,26] and Germany [7,18,29], two from Egypt [20,23] and one each from Poland [24], Turkey [17], Japan [16] and Canada [19]. The articles included spanned from 2005 to 2020 with more articles using clinical diagnosis ( n = 9) than self‐rated ( n = 6) or self‐reported depression (n = 2).…”

“…As with a previous review [15], the diagnosis of depression can be classified into clinical diagnosis, self‐rated questionnaire or self‐reported depression. A clinician‐rated diagnosis was made either through an evaluation by a psychiatrist according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision (DSM‐IV‐TR) or based on the use of antidepressants [5,7,16–23]. Self‐rated questionnaire included the used of validated depression scales (e.g., patient health questionnaire; PHQ‐9 [6,24], Hospital Anxiety and Depression Scale; HADS [25], Korean Center for Epidemiological Studies‐Depression Scale; CES‐D [8], Brief Symptom Rating Scale; BSRS [26], Primary Care Evaluation of Mental Disorders; PRIME‐MD [27]), while self‐reported depression referred to patients’ self‐identification of depressive symptoms post donation [28,29].…”

Bakım verici rolü olan karaciğer nakli donörlerinde bakım yükü ve depresyon arasındaki ilişki

“…25 Yine Mısır'da yapılan bir çalışmada donörlerin yaklaşık beşte birinin majör depresif belirtiler gösterdiği belirlenmiştir. 26 Yaklaşık üçte birinin aynı zamanda donör olduğu bakım vericiler ile yapılan bir çalışmada ise, hasta yakınlarının yarısından fazlasında ciddi düzeyde depresyon yaşandığı belirlenmiştir. 11 Araştırma sonuçlarının benzerlik gösterdiği görülmektedir.…”