Psychosocial profiles within community-dwelling older adults with Mild Cognitive Impairment: A prevalence and latent profile analysis study

Empirically derived psychosocial‐behavioral phenotypes in Black/African American and Hispanic/Latino older adults enrolled in HABS‐HD: Associations with AD biomarkers and cognitive outcomes

“…57,58 Furthermore, as illustrated by another recent HABS-HD investigation, there are distinct proteomic profiles of neurodegeneration in NHL and Latino older adults, and the biological factors underlying neurodegeneration within each racial/ethnic group differ across the MCI and AD phases. 59 While limited, several recent efforts have been made to engage in psychosocial and behavioral phenotyping methods within middle-aged and older adult samples, with specific efforts to take into account the cumulative influence of Although other studies have employed similar empirical methods, 29,30,34 In contrast, there were no differences in performance on the memory composite across the phenotypes. The larger literature has highlighted that executive dysfunction is commonly observed within these ethnoracial groups, and elevated rates of vascular risk and psychiatric symptoms may represent mechanisms underlying this observation.…”

“…[26][27][28] Several recent research investigations started the practice of employing data-driven psychosocial-behavioral phenotyping methods that incorporate multidomain data pertaining to health behaviors, social determinants of health, environmental resources, and psychological functioning. [29][30][31][32][33] These studies have revealed that (1) unique psychosocial phenotypes and combinations of modifiable risk fac- tors can be identified in several samples of older adults and (2) risk for poor cognitive outcomes differ as a function of these identified phenotypes. [29][30][31][32][33] For example, in a large sample of communitydwelling Southeast Asians a latent profile analysis of psychiatric symptom, quality of life, social support, and life satisfaction inventories revealed three psychosocial phenotypes (Positive, Negative, and Neutral); while these groups did not differ in cognitive outcomes, individuals with MCI in the sample were more likely to have lower levels of education and perceived social support and report more severe depressive symptoms.…”

“…Several recent research investigations started the practice of employing data‐driven psychosocial‐behavioral phenotyping methods that incorporate multidomain data pertaining to health behaviors, social determinants of health, environmental resources, and psychological functioning 29–33 . These studies have revealed that (1) unique psychosocial phenotypes and combinations of modifiable risk factors can be identified in several samples of older adults and (2) risk for poor cognitive outcomes differ as a function of these identified phenotypes 29–33 .…”

“… 29 , 30 , 31 , 32 , 33 These studies have revealed that (1) unique psychosocial phenotypes and combinations of modifiable risk factors can be identified in several samples of older adults and (2) risk for poor cognitive outcomes differ as a function of these identified phenotypes. 29 , 30 , 31 , 32 , 33 For example, in a large sample of community‐dwelling Southeast Asians a latent profile analysis of psychiatric symptom, quality of life, social support, and life satisfaction inventories revealed three psychosocial phenotypes (Positive, Negative, and Neutral); while these groups did not differ in cognitive outcomes, individuals with MCI in the sample were more likely to have lower levels of education and perceived social support and report more severe depressive symptoms. 29 Similarly, in a large sample of Latino older adults, a principal component analysis on several acculturation and socioenvironmental variables revealed three composites (acculturation, socioenvironmental, and familism) that displayed varied associations with cognition.…”

“… 29 , 30 , 31 , 32 , 33 For example, in a large sample of community‐dwelling Southeast Asians a latent profile analysis of psychiatric symptom, quality of life, social support, and life satisfaction inventories revealed three psychosocial phenotypes (Positive, Negative, and Neutral); while these groups did not differ in cognitive outcomes, individuals with MCI in the sample were more likely to have lower levels of education and perceived social support and report more severe depressive symptoms. 29 Similarly, in a large sample of Latino older adults, a principal component analysis on several acculturation and socioenvironmental variables revealed three composites (acculturation, socioenvironmental, and familism) that displayed varied associations with cognition. 30 Results revealed the acculturation composite was positively associated with baseline cognition (global, perceptual speed, and episodic memory), whereas the socioenvironmental was negatively associated with baseline cognition (global, perceptual speed, episodic memory, working memory) and faster longitudinal cognitive decline (visuospatial ability).…”