Psychosocial Risk Factors and Cardiovascular Disease and Death in a Population-Based Cohort From 21 Low-, Middle-, and High-Income Countries

Santosa, Ailiana; Rosengren, Annika; Ramasundarahettige, Chinthanie; Rangarajan, Sumathy; Chifamba, Jephat; Lear, Scott A.; Poirier, Paul; Yeates, Karen; Yusuf, Rita; Orlandini, Andreas; Liu, Weida; Li, Sidong; Zhu, Yibing; Mohan, Viswanathan; Kaur, Manmeet; Zatońska, Katarzyna; Ismail, Noorhassim; López‐Jaramillo, Patricio; Iqbal, Romaina; Palileo-Villanueva, Lia M.; Yusufali, Afzalhussein; Alhabib, Khalid F; Yusuf, Salim

doi:10.1001/jamanetworkopen.2021.38920

Cited by 64 publications

(28 citation statements)

References 32 publications

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“…Supporting the hypothesis of stress-acceleration of ageing in humans, some studies suggest chronic stress and stress hormone hypersecretion are associated with increased fat mass, cellular dehydration, osteo-sarcopenia, and frailty 83 . In the Prospective Urban and Rural Epidemiological (PURE) study of 120,000 people, those with higher composite indicator of life stress (stress at work and home, major life events, and financial stress) had higher prevalence of abdominal obesity compared to participants with low life stress 84 . Similarly, long-term socioeconomic adversity has been related to small birth weight (a risk factor for diabetes) but subsequent weight gain and obesity in a number of birth cohort studies (e.g.…”

Section: Impact Of Stress On Body Compositionmentioning

confidence: 99%

The multiple roles of life stress in metabolic disorders

2022

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The stress response is evolutionarily conserved across vertebrates to maintain homeostasis, but in excess can be damaging for body functions. We review the most recent research from basic sciences and epidemiology linking stress to the development and progression of metabolic disorders across the life course. Findings from rodents demonstrate that stress can affect features of metabolic dysfunction, such as insulin resistance, glucose and lipid homeostasis, as well as fundamental ageing processes such as cellular senescence and telomere length shortening. In human studies, stressors in the home, workplace and neighbourhood are associated with accelerated biological ageing and metabolic and immune alterations, both directly as well as indirectly via behavioural risks, including low physical activity, sleep disturbances, and alcohol abuse. The likelihood of developing clinical conditions, such as diabetes and fatty liver disease is increased in individuals with adverse childhood experiences or long-term stress at work or in private life -often as part of disease trajectories associated with other stress-related disorders, such as mental health problems, cardiovascular disease and increased susceptibility to infections. Among people with a metabolic disorder, stress may worsen disease prognosis. As favourable modifications in stressors are associated with reductions in incidence of metabolic disorders, the therapeutic value of targeting stress in personalised medicine merits further investigation.

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Section: Impact Of Stress On Body Compositionmentioning

confidence: 99%

The multiple roles of life stress in metabolic disorders

2022

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“…After a mean follow-up of 10.2 years, it was found that those with high stress, compared to no stress, was associated with a significantly increased risk of cardiovascular disease (HR=1.22) after adjustment for traditional cardiac risk factors. 26 A meta-analysis of prospective cohort studies that measured self-reported perceived stress and subsequent incident coronary heart disease, which included a total of 6 studies and 119,696 participants, determined an aggregate risk ratio of 1.27 (95% CI 1.12-1.45) for those with high perceived stress compared to those with low perceived stress. 27 Many adults spend half their waking life at work, 28 and numerous studies have examined the relationship between work-related stress and cardiovascular disease.…”

Section: Chronic Psychological Stressmentioning

confidence: 99%

Psychological Stress and Heart Disease: Fact or Folklore?

Levine

2022

The American Journal of Medicine

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“…Результаты были скорректированы с учетом возраста, пола, географического региона и статуса курения [50]. В популяционном когортном исследовании (использование данных международного исследования «Prospective Urban Rural Epidemiology study» (PURE) с участием более 100 000 человек), в котором психологический стресс оценивался при включении в исследование, после среднего периода наблюдения в 10,2 года было обнаружено, что люди с высоким уровнем стресса имели более высокий риск развития ССЗ (отношение рисков (ОР) 1,22; 95% ДИ 1,08-1,37) и инсульта (ОР 1,30; 95% ДИ 1,09-1,56) после поправки на традиционные сердечно-сосудистые факторы риска, по сравнению с теми, кто не испытывал стресса [51].…”

Section: Neuropsychiatric Disordersunclassified

Stress as the basis of polymorbidity and ways to correct it in the early stages

et al. 2022

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Stress is an integral part of every person’s daily personal and work life, and one of the important factors affecting health and longevity. Excessive or prolonged stress, exceeding natural regulatory capabilities and adaptive resources of the body, leads to changes in homeostasis and a wide range of problems, including metabolic syndrome, obesity, mental disorders, cardiovascular disease, etc. Given that stress in this context acts as a risk factor for these conditions, and they can be combined in a patient, it can be seen as the basis for the development of polymorbidity. Polymorbidity, the combination of two or more diseases in a patient, is currently regarded as one of the most serious problems of modern medicine, requiring from the doctor in-depth knowledge in various interdisciplinary areas. Polymorbidity is associated with more frequent use of medical care, lower quality of life, and a higher risk of premature mortality. In this regard, understanding the pathophysiology of stress and knowing how to correct it early is an urgent medical challenge that needs to be solved. The present work gives a brief overview of the organization and (patho-)physiology of the human stress system, discusses the role of stress in the development of polymorbidity, in particular its cardiometabolic phenotype, using the example of the relationship between acute and chronic psychological stress and the development of cardiovascular disease, describes ways of stress management in the early stages, including the use of the combined drug phenobarbital and ethylbromizovalerianate with a multimodal spectrum of action.

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Psychosocial Risk Factors and Cardiovascular Disease and Death in a Population-Based Cohort From 21 Low-, Middle-, and High-Income Countries

Cited by 64 publications

References 32 publications

The multiple roles of life stress in metabolic disorders

The multiple roles of life stress in metabolic disorders

Psychological Stress and Heart Disease: Fact or Folklore?

Stress as the basis of polymorbidity and ways to correct it in the early stages

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