Psychosocial Stress-Induced Analgesia: An Examination of Effects on Heat Pain Threshold and Tolerance and of Neuroendocrine Mediation

Gaab, Jens; Jiménez, J. García; Voneschen, Livia; Oschwald, Daniel; Meyer, Andrea; Nater, Urs M.; Kempler, Péter

doi:10.1159/000454986

Cited by 15 publications

(16 citation statements)

References 61 publications

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“…Considering the highly mixed results on the effect of acute stress on pain perception, it appears the type of stress and the magnitude of its appraisal determines its interaction with the pain system (Geva et al, 2014). Similarly, Gaab et al (2016) sought to explore the impact of acute psychosocial stress on heat pain perception in a healthy sample. Results showed that acute psychosocial stress did not impact heat pain threshold but did slightly increase heat pain tolerance, suggesting that psychosocial stress is selectively analgesic for heat pain tolerance.…”

Section: Acute Stress On Pain Perception and Sensory Functioning In Hmentioning

confidence: 99%

Walking the Tightrope: A Proposed Model of Chronic Pain and Stress

Lunde

Sieberg

2020

Front. Neurosci.

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Pain and stress are both phenomena that challenge an individual's homeostasis and have significant overlap in conceptual and physiological processes. Allostasis is the ability to adapt to pain and stress and maintain homeostasis; however, if either process becomes chronic, it may result in negative long-term outcomes. The negative effects of stress on health outcomes on physiology and behavior, including pain, have been well documented; however, the specific mechanisms of how stress and what quantity of stress contributes to the maintenance and exacerbation of pain have not been identified, and thus pharmacological interventions are lacking. The objective of this brief review is to: 1. identify the gaps in the literature on the impact of acute and chronic stress on chronic pain, 2. highlight future directions for stress and chronic pain research; and 3. introduce the Pain-Stress Model in the context of the current literature on stress and chronic pain. A better understanding of the connection between stress and chronic pain could provide greater insight into the neurobiology of these processes and contribute to individualized treatment for pain rehabilitation and drug development for these often comorbid conditions.

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Section: Acute Stress On Pain Perception and Sensory Functioning In Hmentioning

confidence: 99%

Walking the Tightrope: A Proposed Model of Chronic Pain and Stress

Lunde

Sieberg

2020

Front. Neurosci.

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“…We defined posttreatment heat-pain tolerance as the primary outcome. Heat-pain tolerance is related to affective and motivational aspects ( 33 , 36 ) and implies experiencing maximum discomfort, which results in greater subjective stress ( 33 ). In addition, it has been associated with pathological pain, as there is an inverse relationship between ischemic pain tolerance and the perceived severity of clinical pain ( 37 ).…”

Section: Methodsmentioning

confidence: 99%

“…We assessed heat-pain tolerance and heat-pain threshold following the design of previous trials (33)(34)(35). We defined posttreatment heat-pain tolerance as the primary outcome.…”

Section: Measures Pain Ratingsmentioning

confidence: 99%

Lack of Effects of the Presence of a Dog on Pain Perception in Healthy Participants—A Randomized Controlled Trial

et al. 2021

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Animal-assisted interventions (AAIs) have been shown to be effective in the treatment of pain. Studies suggest that relationships with animals can have comparable qualities to relationships with humans and that this enables animals to provide social support. Further, the presence of an animal can strengthen the therapeutic alliance between patients and treatment providers. This suggests that the analgesic effects of AAI might be mediated by social support from an animal or by strengthening the alliance between the patient and the treatment provider. To test these assumptions, we examined the effects of the presence of a dog on experimentally induced pain in a pain assessment and a pain therapy context. Hundred thirty-two healthy participants were randomly assigned to the conditions “pain,” “pain + dog,” “pain + placebo,” or “pain + placebo + dog.” We collected baseline and posttreatment measurements of heat-pain tolerance and the heat-pain threshold and of the corresponding subjective ratings of heat-pain intensity and unpleasantness as well as of participants' perceptions of the study investigator. The primary outcome was heat-pain tolerance. The presence of the dog did not influence the primary outcome (“pain” vs. “pain + dog”: difference = 0.04, CI = −0.66 to 0.74, p = 0.905; “pain + placebo” vs. “pain + placebo + dog”: difference = 0.43, CI = −0.02 to 0.88, p = 0.059). Participants did also not perceive the study investigator to be more trustworthy in the presence of the dog (“pain” vs. “pain + dog”: difference = 0.10, CI = −0.67 to 0.87, p = 0.796; “pain + placebo” vs. “pain + placebo + dog”: difference = 0.11, CI = −0.43 to 0.64, p = 0.695). The results indicate that the mere presence of a dog does not contribute to pain reduction and that the analgesic effects of AAI that previous studies have found is not replicated in our study as AAI did not increase perceived social support and had no effect on the alliance between the participant and the treatment provider. We assume that the animal most likely needs to be an integrated and plausible part of the treatment rationale so that participants are able to form a treatment-response expectation toward AAI.Clinical Trial Registration: This study was preregistered as a clinical trial on www.clinicaltrials.gov (Identifier: NCT0389814).

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“…The stress-induced analgesia (SIA) is an adaptive antinociceptive response following exposure to internal and external stressors (Gaab et al , 2016). Stress and pain have a complex web of interactions and are considered a defensive response to actual or potential damage (Baker et al , 2019).…”

Section: Introductionmentioning

confidence: 99%

The modulatory role of dopamine receptors within the hippocampal cornu ammonis area 1 in stress-induced analgesia in an animal model of persistent inflammatory pain

Dezfouli

Merdasi

Rashvand

et al. 2022

Behavioural Pharmacology

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The intrinsic pain inhibitory mechanisms can be activated by fear, anxiety, and stress. Stressful experiences produce analgesia, referred to as stress-induced analgesia (SIA). Major components of the limbic system, including the ventral tegmental area, nucleus accumbens, amygdala, and hippocampus, are involved in the SIA. In this study, we tried to understand the role of dopamine receptors in the cornu ammonis area 1 (CA1) of the hippocampus in the forced swim stress (FSS)-induced analgesia. Stereotaxic surgery was unilaterally performed on 129 adult male Wistar rats weighing 220–280 g. SCH23390 (0.25, 1, and 4 μg/0.5 μl saline) or sulpiride (0.25, 1, and 4 μg/0.5 μl DMSO), as D1- and D2-like dopamine receptor antagonists, respectively, were microinjected into the CA1 area, 5 min before exposure to FSS for a 6-min period. The vehicle groups received saline or DMSO instead of SCH23390 or sulpiride, respectively. The formalin test was done using formalin injection (50 μl; 2.5%) into the plantar surface of the rat’s hind paw immediately after exposure to FSS. The results demonstrated that FSS produces analgesia during the early and late phases of the formalin test. However, intra-CA1 microinjection of SCH23390 or sulpiride attenuated the FSS-induced analgesia in both phases of the formalin test. This study provides new insight into the role of D1- and D2-like dopamine receptors in the CA1 area in the FSS-induced analgesia during persistent inflammatory pain.

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Psychosocial Stress-Induced Analgesia: An Examination of Effects on Heat Pain Threshold and Tolerance and of Neuroendocrine Mediation

Cited by 15 publications

References 61 publications

Walking the Tightrope: A Proposed Model of Chronic Pain and Stress

Walking the Tightrope: A Proposed Model of Chronic Pain and Stress

Lack of Effects of the Presence of a Dog on Pain Perception in Healthy Participants—A Randomized Controlled Trial

The modulatory role of dopamine receptors within the hippocampal cornu ammonis area 1 in stress-induced analgesia in an animal model of persistent inflammatory pain

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