Psychosomatic Considerations in Hyperuricemia and Gout

Katz, Jack L.; Weiner, Herbert

doi:10.1097/00006842-197203000-00008

Cited by 19 publications

(6 citation statements)

References 66 publications

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“…The relationship between psychological stress and serum levels of uric acid has been discussed due to its clinical significance 1 , but there is no information on how stress affects uric acid metabolism. Uric acid level is regulated by a balance between uric acid formation and excretion driven by several enzymatic pathways, including XOR.…”

Section: Discussionmentioning

confidence: 99%

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Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice

Yisireyili

Hayashi

et al. 2017

Sci Rep

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Chronic stress is closely linked to the metabolic syndrome, diabetes, hyperuricemia and thromboembolism, but the mechanisms remain elusive. We reported recently that stress targets visceral adipose tissue (VAT), inducing lipolysis, low-grade inflammation with production of inflammatory adipokines, metabolic derangements such as insulin resistance, and prothrombotic state. In the present study, we hypothesized the involvement of VAT xanthine oxidoreductase (XOR), a source of reactive oxygen species (ROS) and uric acid (UA) in the above processes. Restraint stress in mice resulted in upregulation of XOR and xanthine oxidase activity, accumulation of ROS in VAT as well as liver and intestine, increase in serum UA levels, upregulation of NADPH oxidase subunits and downregulation of antioxidant enzymes. Immunohistochemistry and RT-PCR analysis also showed that restraint stress induced VAT monocyte accumulation and proinflammatory adipokine production, resulting in reduced insulin sensitivity and induction of plasminogen activator inhibitor-1 and tissue factor in VAT. Treatment with febuxostat, a potent XO inhibitor, suppressed stress-induced ROS production and VAT inflammation, resulting in improvement of serum UA levels, insulin sensitivity, and prothrombotic tendency. Our results suggest that stress perturbs glucose and UA metabolism, and promotes prothrombotic status, and that XO inhibition by febuxostat might be a potential therapy for stress-related disorders.

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Section: Discussionmentioning

confidence: 99%

“…The relationship between hyperuricemia and stress has been discussed for a long time 1 . A study in occupational health also suggested the involvement of stressful conditions, such as shift-work, is in the incidence of hyperuricemia 2 .…”

Section: Introductionmentioning

confidence: 99%

Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice

Yisireyili

Hayashi

et al. 2017

Sci Rep

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“…Another explanation could be less maternal psychosocial adaptation in primigravida [20]. Both of these mechanisms are associated with increased serum uric acid concentrations [21,22]. …”

Section: Discussionmentioning

confidence: 99%

Maternal hyperuricemia in normotensive singleton pregnancy, a prenatal finding with continuous perinatal and postnatal effects, a prospective cohort study

Amini

Sheikh

Hantoushzadeh

et al. 2014

BMC Pregnancy Childbirth

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BackgroundTo assess the association of maternal hyperuricemia with adverse pregnancy outcome and neonatal metabolic, neurologic and respiratory disturbances in normotensive singleton pregnant women.MethodThis prospective multicentric cohort study was conducted on 404 normotensive singleton pregnant women who were admitted for delivery in Vali-Asr and Akbar-Abadi teaching hospitals of Tehran University of Medical Sciences, Tehran, Iran. Upon enrollment maternal and umbilical sera were obtained for determining uric acid levels. 1 and 5 minutes Apgar scores, the need for neonatal resuscitation and neonatal intensive care unit (NICU) admission were recorded. In case of NICU admission a neonatal blood sample was drawn for determining uric acid, blood sugar and bilirubin levels. An intracranial ultrasound imaging was also carried out for the admittd neonates for detecting intraventricular hemorrhage.ResultsMaternal hyperuricemia (uric acid one standard deviation greater than the appropriate gestational age) was independently associated with preterm birth (odds ratio (OR), 3.17; 95% confidence interval (CI), 2.1 – 4.79), small for gestational age delivery (OR, 1.28; 95% CI, 1.04 – 2.57), NICU admission (OR, 1.65; 95% CI, 1.12 – 2.94) and neonatal IVH (OR, 8.14; 95% CI, 1.11 – 87.1).ConclusionsMaternal hyperuricemia in normotensive singleton pregnant women is significantly associated with preterm and SGA delivery and the development of neonatal IVH.

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“…While the link between serum cholesterol and endocrine function is unclear, considerable research has shown cholesterol to be responsive to stress (Rahe et al, 1971). Serum uric acid has also been linked to stress (Kutz and Weiner, 1972).…”

Section: Physiological Variablesmentioning

confidence: 99%