Psychostimulant sensitization: differential changes in accumbal shell and core dopamine

Cadoni, C; Solinas, Marcello; Chiara, G. Di

doi:10.1016/s0014-2999(99)00824-9

Cited by 160 publications

(124 citation statements)

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“…A significant finding of the present study was that the differential contribution of both subdivisions of NAcc to the hyperreactivity of dopaminergic terminals depends on the interval between the stress experience and the drug challenge. The long-term enhanced DA response to d-AMPH in NAcc core resembles that found in a model of opiate-and psychostimulant-induced sensitization Wolf et al, 1993;Paulson and Robinson, 1995;Cadoni and Di Chiara, 1999;Cadoni et al, 2000) as well as that observed in response to different psychostimulants following a chronic schedule of food restriction (Cadoni et al, 2003), while that observed in NAcc shell (ie the short lasting one) is consistent with sensitization to morphine following an inescapable shock administered 24 h previously (Bland et al, 2004). As contradictory evidence has been found in NAcc shell in terms of DA release in models of drug-induced sensitization, it is difficult to relate our present findings to them.…”

Section: Discussionmentioning

confidence: 59%

“…As contradictory evidence has been found in NAcc shell in terms of DA release in models of drug-induced sensitization, it is difficult to relate our present findings to them. For instance, while cross sensitization to d-AMPH in NAcc shell is observed following a repeated treatment with cocaine (Pierce and Kalivas, 1995) it was not found following an opiate and d-AMPH repeated treatment (Cadoni and Di Chiara, 1999;Cadoni et al, 2000). In general terms, the majority of models of drug-induced sensitization mentioned above are based on laboratory animals that have received repeated injections of psychostimulants.…”

Section: Discussionmentioning

confidence: 99%

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A Glutamate–Dopamine Interaction in the Persistent Enhanced Response to Amphetamine in Nucleus Accumbens Core but not Shell Following a Single Restraint Stress

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Bregonzio

et al. 2006

Neuropsychopharmacol

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The administration of psychostimulant drugs or stress can elicit a sensitized response to the stimulating and reinforcing properties of the drug. We previously demonstrated that a single restraint stress session enhanced d-amphetamine (d-AMPH)-induced locomotion the day after the stress session, which lasted up to 8 days. The present experiments were designed to identify the contribution of major dopamine (DA) brain areas in the short-and long-lasting enhancement of d-AMPH-induced locomotion following a single stress, and to test the involvement of N-methyl-D-aspartate (NMDA) receptors in that phenomena. To achieve our goal, 24 h and 8 days after a 2-h restraint stress session either with or without a NMDA receptor blockade, we measured locomotor activity and DA overflow in nucleus accumbens (NAcc) core and shell and caudate putamen (CPu) following a d-AMPH injection (0.5 mg/kg i.p.). The stimulant effect of d-AMPH on DA overflow was enhanced in all nuclei at 24 h after a single stress, while at 8 days the enhanced responsiveness was maintained only in the NAcc core. When the rats were administered with MK-801 (0.1 mg/kg i.p.) 30 min before restraint stress, the d-AMPH-induced enhancement on locomotor activity and DA neurotransmission was prevented in all studied brain areas at both times. These findings show that a glutamate-dopamine link is underlying the short-and long-term d-AMPH-induced enhancement on DA and locomotor activity following stress. The persistent glutamate-dependent DA enhancement in NAcc core highlights the relevance of this region in the long-term proactive effects of stress on vulnerability to drug abuse.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

A Glutamate–Dopamine Interaction in the Persistent Enhanced Response to Amphetamine in Nucleus Accumbens Core but not Shell Following a Single Restraint Stress

Pacchioni

Cador

Bregonzio

et al. 2006

Neuropsychopharmacol

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“…The core subdivision of the nucleus accumbens is thought to be especially important in the development of Pavlovian conditioned approach behavior [20,37,38] and has also been implicated in responsivity to reward-related cues [28] and in psychomotor sensitization [10,34,42], including the emergence of progressively stereotyped behavior following the repeated administration of cocaine [33]. In contrast, the shell of the accumbens is thought to be involved in mediating the acute psychomotor activating effects of psychostimulant drugs and the actions of primary rewards [33,49].…”

Section: Discussionmentioning

confidence: 99%

Individual differences in the attribution of incentive salience to a reward-related cue: Influence on cocaine sensitization

Flagel

Watson

Akil

et al. 2008

Behavioural Brain Research

213

187

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When a discrete cue (a "sign") is presented repeatedly in anticipation of a food reward the cue can become imbued with incentive salience, leading some animals to approach and engage it, a phenomenon known as "sign-tracking" (the animals are sign-trackers; STs). In contrast, other animals do not approach the cue, but upon cue presentation go to the location where food will be delivered (the goal). These animals are known as goal-trackers (GTs). It has been hypothesized that individuals who attribute excessive incentive salience to reward-related cues may be especially vulnerable to develop compulsive behavioral disorders, including addiction. We were interested, therefore, in whether individual differences in the propensity to sign-track are associated with differences in responsivity to cocaine. Using an autoshaping procedure in which lever (conditioned stimulus) presentation was immediately followed by the response-independent delivery of a food pellet (unconditioned stimulus), rats were first characterized as STs or GTs and subsequently studied for the acute psychomotor response to cocaine and the propensity for cocaine-induced psychomotor sensitization. We found that GTs were more sensitive than STs to the acute locomotor activating effects of cocaine, but STs showed a greater propensity for psychomotor sensitization upon repeated treatment. These data suggest that individual differences in the tendency to attribute incentive salience to a discrete reward-related cue, and to approach and engage it, are associated with susceptibility to a form of cocaine-induced plasticity that may contribute to the development of addiction.

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“…This is in agreement with Simpson and colleagues (1995), who showed that Fos is significantly induced in core but not shell neurons of AMPHsensitized rats. Moreover, sensitization could be associated with alterations in glutamate and dopamine release in the NAc core, but not the shell (Cadoni et al 2000;Giorgi et al 2005;Pierce et al 1996; but see Hedou et al 1999;Pierce and Kalivas 1995). Nevertheless, there is a strong trend towards significance in the shell with our results, which agrees with earlier work by Hedou and colleagues (2002).…”

Section: Activation Of Mpfc Target Regionsmentioning

confidence: 99%

Repeated amphetamine administration induces Fos in prefrontal cortical neurons that project to the lateral hypothalamus but not the nucleus accumbens or basolateral amygdala

Morshedi

Meredith

2007

Psychopharmacology

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Rationale-The development of sensitization to amphetamine (AMPH) is dependent on increases in excitatory outflow from the medial prefrontal cortex (mPFC) to subcortical centers. These projections are clearly important for the progressive enhancement of the behavioral response during drug administration that persists through withdrawal.Objectives-The objective of this study was to identify the mPFC subcortical pathway(s) activated by a sensitizing regimen of AMPH.Methods-Using retrograde labeling techniques, Fos activation was evaluated in the predominant projection pathways of the mPFC of sensitized rats following a challenge injection of AMPH.Results-There was a significant increase in Fos-immunoreactive cells in the mPFC, nucleus accumbens (NAc), basolateral amygdala (BLA), and lateral hypothalamus (LH) of rats treated repeatedly with AMPH when compared to vehicle-treated controls. The mPFC pyramidal neurons that project to the LH, but not the NAc or BLA, show a significant induction of Fos after repeated AMPH treatment. In addition, we found a dramatic increase in Fos-activated orexin neurons.Conclusions-The LH, a region implicated in natural and drug reward processes, may play a role in the development and persistence of sensitization to repeated AMPH through its connections with the mPFC and possibly through its orexin neurons.

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Psychostimulant sensitization: differential changes in accumbal shell and core dopamine

Cited by 160 publications

References 35 publications

A Glutamate–Dopamine Interaction in the Persistent Enhanced Response to Amphetamine in Nucleus Accumbens Core but not Shell Following a Single Restraint Stress

A Glutamate–Dopamine Interaction in the Persistent Enhanced Response to Amphetamine in Nucleus Accumbens Core but not Shell Following a Single Restraint Stress

Individual differences in the attribution of incentive salience to a reward-related cue: Influence on cocaine sensitization

Repeated amphetamine administration induces Fos in prefrontal cortical neurons that project to the lateral hypothalamus but not the nucleus accumbens or basolateral amygdala

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