“…As at the time no more than one study used some form of randomization (Gowers, Norton, Halek, & Crisp, 1994), this problem holds for nearly all of the studies of the treatment outcome of AN. The only way to exclude such alternative explanations in nonrandomized studies is to measure the influence of potentially confounding variables and then control for these in multivariate analyses (Garner, 1987;Herzog, Rathner et al, 1992;Steinhausen & Glanville, 1983a;Szmukler & Russell, 1986;Yates, 1990). It should be noted that such multivariate statistical control is impossible when patients with previous treatment are not considered separately as the unique influences of denial, comorbidity, negative selection, treatment failures, and chronicity are inextricably interwoven in such cases (Goldberg et al, 1980).…”