Psychotherapy use in bipolar disorder: Association with functioning and illness severity

Sylvia, Louisa G.; Thase, Michael E.; Reilly-Harrington, Noreen A.; Salcedo, Stephanie; Brody, Benjamin D.; Kinrys, Gustavo; Kemp, David E.; Shelton, Richard C.; McElroy, Susan L.; Kocsis, James H.; Bobo, William V.; Kamali, Masoud; McInnis, Melvin G.; Friedman, Edward S.; Tohen, Mauricio; Bowden, Charles L.; Ketter, Terence A.; Singh, Vivek; Calabrese, Joseph R.; Nierenberg, Andrew A.; Rabideau, Dustin J.; Elson, Constance; Deckersbach, Thilo

doi:10.1177/0004867415569803

Cited by 20 publications

(5 citation statements)

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“… 1 Pharmacotherapy with mood stabilisers and antipsychotics may not lead to sustained remission and more than two-thirds of those treated experience a recurrence within 5 years. 2 Given such poor treatment outcomes, novel approaches to improve therapeutic interventions are an important objective of bipolar disorder research. Mounting, albeit inconsistent, evidence suggests that testosterone may play a role in the pathophysiology of mood disorders.…”

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confidence: 99%

An exploration of testosterone levels in patients with bipolar disorder

et al. 2015

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BackgroundTestosterone influences well-being, mood and cognition and may play a role in the pathophysiology of bipolar disorder.AimTo examine testosterone levels in patients with bipolar disorder compared with healthy controls.MethodWe examined baseline total testosterone levels and current depression scores in male and female patients with bipolar disorder and mild to moderate depression and healthy controls.ResultsA significant interaction between diagnosis and gender was observed (F(2,97)=9.791, P=0.002). Testosterone levels were significantly lower for male patients with bipolar disorder compared with male controls (P=0.001). Women with bipolar disorder had significantly higher testosterone levels than female controls (P=0.03).ConclusionsDisturbances in testosterone levels may represent an important neurobiological abnormality in bipolar disorder and may differ by gender. If these findings are confirmed, the use of gender appropriate treatment strategies for the normalisation of testosterone levels in bipolar disorder depression should be further explored.Declaration of interestNone.Copyright and usage© The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.

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confidence: 99%

An exploration of testosterone levels in patients with bipolar disorder

et al. 2015

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“…However, researchers have typically included all psychiatric conditions together in their analyses, leaving it unknown whether these diminished help-seeking behaviors generalize to serious mental illnesses, and one possibility is that the severity of symptoms would increase help seeking even among minority individuals. Consistent with this idea, in one study of bipolar disorder, Hispanics and non-Hispanic patients did not differ significantly in self-reported psychotherapy use in the 90 days before assessment [31]. Another study found that black and white individuals with bipolar disorder in a nationally representative sample did not differ in the rates of help seeking or types of care sought [15].…”

Section: Service Utilization Disparitiesmentioning

confidence: 93%

Disparities in Treatment and Service Utilization Among Hispanics and Non-Hispanic Whites with Bipolar Disorder

Salcedo

McMaster

Johnson

2016

J. Racial and Ethnic Health Disparities

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Objectives Due to the serious and recurrent nature of bipolar disorder, continuous long-term medication treatment is typically recommended. Little is known about whether these treatment recommendations are effectively implemented for Hispanics. This study examined differences in mood stabilizer use and mental health service utilization between adult English-speaking Hispanic and non-Hispanic white respondents with bipolar disorder. Methods The sample included 163 participants with lifetime bipolar I and II disorders in the National Comorbidity Survey Replication. Demographics, symptom presentation, and acculturation were examined as covariates. Results None of the 26 Hispanic respondents were taking mood-stabilizing medication, compared to 21% of non-Hispanic whites, and Hispanics were less likely to receive medications for emotional problems, see a professional for manic episodes, or attend psychotherapy. Even after accounting for differences in symptom profiles and sociodemographics, ethnicity continued to be a significant predictor of mood stabilizer use and psychotherapy attendance. There was a nonsignificant trend towards lower acculturation among Hispanics being associated with even poorer service utilization. Conclusions No Hispanics were receiving minimally adequate treatment for their bipolar disorder. Future research should focus on identifying the barriers that lead to these stark ethnic disparities in treatment.

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“…In addition, supportive care and cognitive-behavioral psychotherapy are likely to be useful clinically, and have research support for both unipolar MDD and BD [24,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95]. …”

Section: Emerging Treatmentsmentioning

confidence: 99%