Psychotic depression in hospitalized patients: Longitudinal outcomes of psychotic vs. nonpsychotic depression among inpatients

Costa, Felipe Bauer Pinto da; Trachtenberg, Eduardo; Böni, A; Alves, Lucas Primo de Carvalho; Magalhães, Pedro Vieira da Silva; Rocha, Neusa Sica da

doi:10.1016/j.jpsychires.2020.06.002

Cited by 14 publications

(7 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies have shown that the proportion of depression with psychotic symptoms in patients with depression is 15-19% (20), which may be related to differences in the study population, ethnicity, assessment of psychotic symptoms, and diagnostic criteria. In terms of associated psychiatric symptoms, the age of onset is younger and more common in childhood, consistent with previous studies (21). A study of 129 depressed adolescents found that individuals with psychotic symptoms were more likely to have a history of childhood trauma, especially severe sexual abuse (22).…”

Section: Discussionsupporting

confidence: 88%

Retrospective Analysis of Clinical Characteristics and Treatment of Children and Adolescents with Depression

Jiang

Zheng

Yang

et al. 2023

Preprint

View full text Add to dashboard Cite

The purpose of this study was to analyze the demographics, clinical characteristics, and treatment of depression in children and adolescents in different age groups. A total of 635 cases of children and adolescents with depression in a hospital were collected through electronic records from January 2014 to December 2021. They were grouped according to the age of onset, amounting to 115 cases in childhood (8–12), 359 early adolescents (13–15), and 161 cases in late adolescence (16–18). The three groups were compared in terms of general conditions, clinical characteristics, and treatment. Results showed that over the past 8 years, the proportion of hospitalizations in the early adolescence group has been increasing, that in the late adolescence group was lower than that in previous years, and gender (X2 = 16.66, P < 0.001), psychotic symptoms (X2 = 6.224, P = 0.045), and disease course (Z = 84.617, P < 0.001) were significantly different. No significant differences were found in drug treatment regimen, suicide, length of hospital stay, or family history among the three groups. There were differences in the general conditions and clinical characteristics of children and adolescents with depression at different onset ages. The number of hospitalized children and adolescents with depression is increasing annually, and the proportion of hospitalizations in the children group was higher than that in previous years. Females are more likely to suffer from the disease and present more psychotic symptoms. The course of the disease in the early adolescence group was shorter than that in the other two groups, and the late adolescence group had more males and fewer psychotic symptoms.

show abstract

Section: Discussionsupporting

confidence: 88%

Retrospective Analysis of Clinical Characteristics and Treatment of Children and Adolescents with Depression

Jiang

Zheng

Yang

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…When psychosis was defined only as the presence of hallucinations or delusions, severity of depression was similar in the psychotic and nonpsychotic groups, and severity of depression was only weakly correlated with severity of psychosis [13]. In a recent prospective study of 288 depressed inpatients, severity of depression was equivalent in the 45% of patients with psychotic and the 55% with nonpsychotic depression, although functional impairment was greater in the psychotic patients [14].…”

Section: Evolution Of the Concept Of Psychotic Depressionmentioning

confidence: 99%

“…Studies in specialty settings suggest that psychotic features are present in 6-25% of patients with MDD [4,[18][19][20][21]. Around 25-45% of all adult inpatients with MDD, and 24-53% of geriatric patients hospitalized for depression, have been reported to have psychotic features [4,14,18,22]. Since psychotic symptoms are often overlooked in depressed patients, the true prevalence of psychotic depression is likely to be underestimated [4].…”

Section: Evolution Of the Concept Of Psychotic Depressionmentioning

confidence: 99%

Psychotic Depression: Diagnosis, Differential Diagnosis, and Treatment

Dubovsky

Ghosh

Serotte

et al. 2020

Psychother Psychosom

119

View full text Add to dashboard Cite

Psychotic depression was initially considered to be at one end of a continuum of severity of major depression. Subsequent experience demonstrated that psychosis is an independent trait that may accompany mood disorders of varying severity. While much has been learned about the impact of severe mood congruent delusions and hallucinations on the course and treatment response of depression, less is known about fleeting or mild psychosis, mood incongruent features, or psychotic symptoms that reflect traumatic experiences. Acute treatment of psychotic unipolar depression generally involves the combination of an antidepressant and an antipsychotic drug or electroconvulsive therapy. There is inadequate information about maintenance treatment of unipolar psychotic depression and acute and chronic treatment of psychotic bipolar disorder. Decision-making therefore still must rely in part on clinical experience.

show abstract

“…About 0.4% of the general population suffers from unipolar major depression with psychotic characteristics (PD), a serious and incapacitating condition with a substantially greater frequency in individuals over 50 ( Jääskeläinen et al, 2018 ). It has a more severe clinical course, more depressive symptoms, more cognitive dysfunction, and more psychomotor impairment than non-psychotic depression ( da Costa et al, 2020 ). Additionally, it is linked to a higher risk of mortality and recurrence ( Jääskeläinen et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio as a predictive biomarker for early diagnosis of depression: A narrative review

Ghafori,

Yousefi,

Bakhtiari

et al. 2024

Brain, Behavior, & Immunity - Health

View full text Add to dashboard Cite

Psychotic depression in hospitalized patients: Longitudinal outcomes of psychotic vs. nonpsychotic depression among inpatients

Cited by 14 publications

References 49 publications

Retrospective Analysis of Clinical Characteristics and Treatment of Children and Adolescents with Depression

Retrospective Analysis of Clinical Characteristics and Treatment of Children and Adolescents with Depression

Psychotic Depression: Diagnosis, Differential Diagnosis, and Treatment

Neutrophil-to-lymphocyte ratio as a predictive biomarker for early diagnosis of depression: A narrative review

Contact Info

Product

Resources

About