Psychotropic Drugs and Their Effects on Lower Urinary Tract Function: an Update

Chung, Amanda; Cheng, Janice; Tse, Vincent

doi:10.1007/s11884-016-0372-5

Cited by 9 publications

(2 citation statements)

References 30 publications

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“…These medications are centrally acting and thus may have an impact on bladder, bowel, and sexual function. Use of these drugs may impair bladder function, which can present in the form of either urinary retention or incontinence [ 41 ]. Similarly, gastrointestinal hypomotility is a reported side effect of some antipsychotic medication use, typically constipation [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

High Frequency of Concomitant Bladder, Bowel, and Sexual Symptoms in Huntington’s Disease: A Self-Reported Questionnaire Study

Vicars

Liu

Holt

et al. 2021

JPM

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Huntington’s disease (HD) can be associated with pathologic involvement beyond the striatum including the autonomic nervous system. Bladder, bowel, and sexual dysfunction have been reported independently in HD, but little is known about their concomitant occurrence. To document this concomitant phenomena, forty-eight subjects (54% male, ages 28–74 years, CAG repeat 38–61) with manifest/symptomatic HD completed detailed questionnaires regarding bladder, bowel, and sexual function. In total, 45 subjects (93.8%) reported symptoms in at least one organ system (bladder, bowel, or sexual), 13 (27.1%) reported symptoms in two systems, and 19 (39.6%) reported concomitant symptoms in all three systems. Urinary problems were most frequent in 42 subjects (87.5%) followed by lower bowel (60.4%) and sexual dysfunction (56.2%). Participants reporting concomitant symptoms were more likely to have longer duration of disease and lower Total Functional Capacity (TFC) scores. This study documents the high frequency of bladder, bowel, and sexual dysfunction in HD and the common occurrence of concomitance of these pelvic organ problems.

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Section: Discussionmentioning

confidence: 99%

High Frequency of Concomitant Bladder, Bowel, and Sexual Symptoms in Huntington’s Disease: A Self-Reported Questionnaire Study

Vicars

Liu

Holt

et al. 2021

JPM

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show abstract

“…103 Antipsychotics and antidepressants constitute the mainstay of pharmacological treatment of HD, but they may impair bladder function. 104 However, in one uncontrolled cross-sectional study evaluating 48 HD patients with a self-reported questionnaire, 23 nine of 10 subjects on no medications reported at least one pelvic organ system problem (urinary, genital or distal bowel), suggesting that medications were not the main cause of the dysfunction.…”

Section: Urinary Disordersmentioning

confidence: 99%

Systemic Symptoms in Huntington's Disease: A Comprehensive Review

Mehanna,

Jankovic

2024

Movement Disord Clin Pract

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BackgroundAlthough Huntington's disease (HD) is usually thought of as a triad of motor, cognitive, and psychiatric symptoms, there is growing appreciation of HD as a systemic illness affecting the entire body.ObjectivesThis review aims to draw attention to these systemic non‐motor symptoms in HD.MethodsWe identified relevant studies published in English by searching MEDLINE (from 1966 to September 2023), using the following subject headings: Huntington disease, autonomic, systemic, cardiovascular, respiratory, gastrointestinal, urinary, sexual and cutaneous, and additional specific symptoms.ResultsData from 123 articles were critically reviewed with focus on systemic features associated with HD, such as cardiovascular, respiratory, gastrointestinal, urinary, sexual and sweating.ConclusionThis systematic review draws attention to a variety of systemic and autonomic co‐morbidities in patients with HD. Not all of them correlate with the severity of the primary HD symptoms or CAG repeats. More research is needed to better understand the pathophysiology and treatment of systemic and autonomic dysfunction in HD.

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Theories of Toileting

Jiang

Matson

2017

Clinical Guide to Toilet Training Children

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Psychotropic Drugs and Their Effects on Lower Urinary Tract Function: an Update

Cited by 9 publications

References 30 publications

High Frequency of Concomitant Bladder, Bowel, and Sexual Symptoms in Huntington’s Disease: A Self-Reported Questionnaire Study

High Frequency of Concomitant Bladder, Bowel, and Sexual Symptoms in Huntington’s Disease: A Self-Reported Questionnaire Study

Systemic Symptoms in Huntington's Disease: A Comprehensive Review

Theories of Toileting

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