This study examined differences in the use of medications in two birth cohorts (born from 1916 to 1926 and from 1927 to 1937) wave, in 2008 (n = 620). The number of medications currently consumed (mean = 4.6 and 3.4, respectively) and prevalence of polypharmacy (46.6% and 29.1%, respectively) The high prevalence of chronic illnesses among the elderly is associated with high consumption of medications by this population group 3 . In the elderly population, the risks associated with consumption of medications compete with the expected benefits, due to the physiological changes proper to aging, including the decrease in muscle mass and body water, with effects on the pharmacodynamics and pharmacokinetics of medications. Thus, unwanted effects (adverse effects and drug-drug interactions) are more likely to occur 4 .The prevalence of polypharmacy is high in the elderly 5,6,7 , and is one of the strongest predictors of health problems associated with use of medications 4 . Polypharmacy is defined as the use of multiple medications, a basically quantita-ARTIGO ARTICLE Loyola Filho AI et al.