Pt/Ag‐PEG‐Ce6 Nanosystem with Enhanced Near‐Infrared Absorption and Peroxidase‐Like Activity for Synergistic Photodynamic/Photothermal Therapy

Abstract

Noble metals and their alloy‐based nanomaterials are widely used in biomedicine, especially in the fields of photodynamic therapy (PDT) and photothermal therapy (PTT) on tumors, due to their remarkable physicochemical properties. Nonetheless, novel doping strategies with unexpected efficacies are still challenging and formidable. Herein, a photosensitizer‐alloy nanosystem is designed for highly efficient PDT and PTT. Specifically, the optimized Pt/Ag alloy nanoparticles are facilely synthesized in one step at room temperature and are simultaneously endowed with enhanced peroxidase‐like activity and photothermal conversion, and further activated cytotoxic singlet oxygen (1O2) productivity after covalent functionalization of chlorin e6 (Ce6). A small amount of Ag doping can kill two birds with one stone by simultaneously enhancing the synergistic PDT and PTT potential of Pt/Ag‐PEG‐Ce6 nanoparticles. Both in vitro and in vivo experimental results indicate that the significant temperature increase triggered by 808 nm laser and a large amount of toxic 1O2 excited by 671 nm laser synergistically and strongly kill tumor cells. Therefore, through proper doping and improved physicochemical properties, this nanosystem achieves effective PDT and PTT of tumors and also inspires the advanced design of noble metal‐based nanomedicine.

Plasmon-enhanced nano-photosensitizers: game-changers in photodynamic therapy of cancers

“…[75][76][77][78] After a PS covalently bonded to metal/plasmonic alloy NPs, the NPs indicated peroxidase-like activity, and 1 O 2 generation was activated. 79 Pd and Pt have been used mostly for this scenario to possess the catalase (CAT)-mimicking activity and enhance the PDT process by speeding up the H 2 O 2 disintegration into O 2 in a cancer microenvironment. The plasmonic nanoparticle hybridization (tipped structures, core-shell structures, or alloyed structures, to name a few) with metallic nanoparticles can be carried out via chemical synthesis routes and mainly via the polyol method due to its precise control over the synthesis products (morphology, size, and composition).…”

Single Nanovesicles Tracking Reveals Their Heterogeneous Extracellular Adsorptions

“…The vigorous pharmaceutical nanoparticles and nanocarriers endow significant possibilities for effective therapeutics of various diseases. [1][2][3][4][5][6][7] Especially, the advanced nanovesicles (NVs) represented by artificial liposomes [4,5] and natural exosomes [8][9][10] and cytomembranes [11,12] show great potential in the fields of cell-to-cell communications, [13] tumor theranostics, [14] and gene deliveries, [15,16] etc. [17] A series of complex and dynamic behaviors including extracellular diffusions, [18,19] receptor DOI: 10.1002/smll.202301888 recognitions and transmembrane, [20][21][22][23] and intracellular transports [24][25][26] contain plenty of valuable physiological and pathological significances.…”

An NIR fluorescent/photoacoustic dual-mode probe of NADPH for tumor imaging

“…15,16 In contrast, photoacoustic (PA) imaging is an integrated imaging method, which combines laser excitation with acoustic detection to provide higher tissue penetration depth for in vivo imaging (up to ∼5 cm) and is used in tissue and vascular imaging. 17–19 However, turning-on PA probes which can be intelligently activated by specific biological events ( e.g. NADPH) are still rarely reported.…”