PT367 Chronic nicotine administration impairs aortic function in Sprague-Dawley rat

Lim, Yi Cheng; Zainalabidin, Satirah; Ramalingam, Anand; Budin, Siti Balkis

doi:10.1016/j.gheart.2014.03.2090

Cited by 1 publication

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“…MPO activity in the spleen and kidneys was measured using hydrogen peroxide, and odianisidine dihydrochloride. Spleen and kidney tissue homogenates were prepared as recommended by Kim et al [20] and Ramalingam et al [21]. About 7 µL of tissue homogenates were added into the microwells, followed by 200 µL of o-dianisidine, then measured immediately thrice at 450 nm with 30 second intervals between each reading.…”

Section: Estimation Of Myeloperoxidase (Mpo) Activitymentioning

confidence: 99%

Effect of Myocardial Infarction on Spleen and Kidney of Isoprenaline-Induced Myocardial Injury Rat Model

et al. 2019

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Myocardial infarction (MI)-associated inflammation is crucial for post-infarct healing. However, unregulated inflammation may lead to unnecessary systemic inflammation, and affect other organs. This study investigated the effects of MI on spleen and kidneys over early time-points (2 and 7 days) in isoprenaline-induced MI rat model. MI was evident by elevated levels of cardiac injury marker, troponin T, and lactate dehydrogenase (LDH). MI rats showed significant upregulation of myeloperoxidase (MPO) activity at day-2 post infarct while kidney MPO activity remained unaffected. Kidney function test revealed only slightly increased plasma urea at day-2 post MI with no changes in plasma creatine at both time-points. Histological observation on the spleen showed disorganization of spleen structure at day-2 post MI while the kidney structures were preserved at both time-points. In conclusion, although MI-associated damages in the spleen were seen at day-2 post infarct, it had no impact on the kidney structures at both time-points.

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Section: Estimation Of Myeloperoxidase (Mpo) Activitymentioning

confidence: 99%