PtdIns(3,4,5)P3 Binding Protein Screening Reveals Unique Molecules Involved in Endocytic Processes

Somlata,; Bharadwaj, Ravi; Nozaki, Tomoyoshi

doi:10.1007/978-3-030-44826-4_18

Cited by 1 publication

(2 citation statements)

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“…It is important in future studies to determine whether other AGCKs are also specifically or universally involved in trogocytosis and phagocytosis, and which class I PI3Ks activate such AGCKs. Furthermore, two Rho guanine nucleotide exchange factor (RhoGEFs) and one formin domain containing protein were identified as PtdIns(3,4,5)P 3 binding proteins [135], which also reinforces the notion that PtdIns(3,4,5)P 3 is involved in cytoskeleton reorganization (see below).…”

Section: Phosphatidylinositol Calcium Signaling and Protein Kinasessupporting

confidence: 69%

“…Among a number of phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P 3 ] binding proteins, AGCK1 was shown to be exclusively involved in trogocytosis [ 105 , 135 ] ( Figure 1 c). AGCK1 and another isotype of AGCK, AGCK2, were identified by affinity pull down using PtdIns(3,4,5)P 3- immobilized beads in our attempt to isolate PtdIns(3,4,5)P 3 binding proteins [ 105 ].…”

Section: Molecular Mechanisms Of Trogocytosis In E Histolyticamentioning

confidence: 99%

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Trogocytosis in Unicellular Eukaryotes

Nakada‐Tsukui

Nozaki

2021

Cells

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Trogocytosis is a mode of internalization of a part of a live cell by nibbling and is mechanistically distinct from phagocytosis, which implies internalization of a whole cell or a particle. Trogocytosis has been demonstrated in a broad range of cell types in multicellular organisms and is also known to be involved in a plethora of functions. In immune cells, trogocytosis is involved in the “cross-dressing” between antigen presenting cells and T cells, and is thus considered to mediate intercellular communication. On the other hand, trogocytosis has also been reported in a variety of unicellular organisms including the protistan (protozoan) parasite Entamoeba histolytica. E. histolytica ingests human T cell line by trogocytosis and acquires complement resistance and cross-dresses major histocompatibility complex (MHC) class I on the cell surface. Furthermore, trogocytosis and trogocytosis-like phenomena (nibbling of a live cell, not previously described as trogocytosis) have also been reported in other parasitic protists such as Trichomonas, Plasmodium, Toxoplasma, and free-living amoebae. Thus, trogocytosis is conserved in diverse eukaryotic supergroups as a means of intercellular communication. It is depicting the universality of trogocytosis among eukaryotes. In this review, we summarize our current understanding of trogocytosis in unicellular organisms, including the history of its discovery, taxonomical distribution, roles, and molecular mechanisms.

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Section: Phosphatidylinositol Calcium Signaling and Protein Kinasessupporting

confidence: 69%