Pterosin sesquiterpenes and lignans from Pteris laeta Wall. and their neuroprotective bioactivity

Zhang, Yan; Li, Chunbin; Xu, Haishun; Lin, Bi-Hui; Chen, Ji-Cong; Zhao, Yu-Meng; Yang, Jingxian; Zhang, Xu-Fu; Shi, Yu-Sheng

doi:10.1016/j.molstruc.2022.132890

Cited by 4 publications

(6 citation statements)

References 33 publications

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“…Extraction and isolation were performed according to our previous report. 17 In brief, the air-dried powdered roots of P. laeta Wall. (10 kg) were extracted with 95% ethanol (5 h × 3) and yielded 95% ethanol extract (800 g), which was named PW.…”

Section: Methodsmentioning

confidence: 99%

“…were collected in Xishuangbanna Dai Autonomous Prefecture of Yunnan Province, People’s Republic of China, and identified by Prof. Xiao-Zhong Chen from Heilongjiang University of Traditional Chinese Medicine. Extraction and isolation were performed according to our previous report . In brief, the air-dried powdered roots of P. laeta Wall.…”

Section: Methodsmentioning

confidence: 99%

“…Our previous research first reported that three new pterosin sesquiterpenes, three new lignans, and sixteen known compounds were isolated from P. laeta Wall. 17 Among them, pterosin sesquiterpenes represented by pterosin B exhibited good neuroprotective effects. In continuation of our search for neuroprotective pterosin sesquiterpenes with novel structures from P. laeta Wall., one new pterosin sesquiterpene, named pterosinsade A (PA), was isolated.…”

Section: Introductionmentioning

confidence: 99%

“…Usually, it has been made into traditional tea and dishes in China and also used as an anti-inflammatory agent. Our previous research first reported that three new pterosin sesquiterpenes, three new lignans, and sixteen known compounds were isolated from P. laeta Wall . Among them, pterosin sesquiterpenes represented by pterosin B exhibited good neuroprotective effects.…”

Section: Introductionmentioning

confidence: 99%

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Pteris laeta Wall. and Its New Phytochemical, Pterosinsade A, Promote Hippocampal Neurogenesis via Activating the Wnt Signaling Pathway

Shi

Chen

Lin

et al. 2023

J. Agric. Food Chem.

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Pteris laeta Wall., as a traditional tea, is popular in Southwest China, but its role in preventing cognitive impairment is unclear. In this study, Pteris laeta Wall. extracts (PW) and its active compounds were evaluated for preventive effects on Alzheimer’s disease (AD) in vivo and in vitro. The results showed that PW diminished oxidative stress damage and apoptosis of Aβ-induced HT22 cells and also rescued cognitive deficits, and ameliorated pathological injury and inflammatory response in APP/PS1 mice. Besides, a new pterosin sesquiterpene, named pterosinsade A (PA), and nine known compounds were discovered from the EtOAc extract that possessed the best neuroprotective activity. PA reduced apoptosis of APP-overexpressing neural stem cells and promoted their proliferation and neuronal differentiation. Meanwhile, PW and PA promoted hippocampal neurogenesis, which proved to be associated with activating the Wnt signaling pathway. These findings suggest that PW and PA are candidates for AD prevention.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pteris laeta Wall. and Its New Phytochemical, Pterosinsade A, Promote Hippocampal Neurogenesis via Activating the Wnt Signaling Pathway

Shi

Chen

Lin

et al. 2023

J. Agric. Food Chem.

Self Cite

View full text Add to dashboard Cite

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“…Lignans are secondary metabolites of the oxidative dimerization of phenylpropanoids and have been studied for their various biological activities (Barker, 2019). Many studies have confirmed the neuroprotective effects of lignan or lignan rich-extract, such as lignans from Eucommia ulmoides (Han et al, 2022), lignans from Crataegus piatifida (Xin et al, 2022), and lignans form Pteris laeta (Zhang et al, 2022). In addition, lignans have been clinically proven as a potential antioxidant.…”

Section: Gc-ms Analysismentioning

confidence: 99%

Neuroprotective potential of lignan-rich fraction of Piper cubeba L. by improving antioxidant capacity in the rat's brain

et al. 2022

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Piper cubeba contains various types of lignans. These compounds have been found to have potential pharmacological activities, one being a neuroprotector through an antioxidant mechanism, especially in the brain. This study examined the antioxidant activity of the lignan-rich fraction of P. cubeba (LF) in rat brains. The rats were given LF (200 and 400 mg/kg), Vitamin C (200 mg/kg), and a carrier as the control group for one-week p.o. The following day, rat brains were collected for antioxidant tests, including examining lipid peroxide inhibition, superoxide dismutase and catalase activity, and determination of nitric oxide (NO) concentration. The phytochemical compounds were analyzed with thin-layer chromatography (TLC), ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS), and gas chromatography-mass spectrometry (GC-MS). Test results show that the LF of both doses of 200 and 400 mg/kg could significantly increase antioxidant activity in the brain by inhibiting lipid peroxidation. LF could also increase catalase, despite the decrease in superoxide dismutase activity. Reduction in NO only occurred in the LF-200 group, while LF-400 showed insignificant results compared to the control group. In conclusion, LF showed potential as an antioxidant in the brain and could be beneficial for treating neurological diseases.

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Pterosin sesquiterpenoids from Pteris laeta Wall. ex Ettingsh. protect cells from glutamate excitotoxicity by modulating mitochondrial signals

Cheng

Zhang

Sun

et al. 2023

Journal of Ethnopharmacology

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Pterosin sesquiterpenes and lignans from Pteris laeta Wall. and their neuroprotective bioactivity

Cited by 4 publications

References 33 publications

Pteris laeta Wall. and Its New Phytochemical, Pterosinsade A, Promote Hippocampal Neurogenesis via Activating the Wnt Signaling Pathway

Pteris laeta Wall. and Its New Phytochemical, Pterosinsade A, Promote Hippocampal Neurogenesis via Activating the Wnt Signaling Pathway

Neuroprotective potential of lignan-rich fraction of Piper cubeba L. by improving antioxidant capacity in the rat's brain

Pterosin sesquiterpenoids from Pteris laeta Wall. ex Ettingsh. protect cells from glutamate excitotoxicity by modulating mitochondrial signals

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