2021
DOI: 10.1186/s13020-021-00474-7
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Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2

Abstract: Background Idiopathic pulmonary fibrosis (IPF) is a serious chronic disease of the respiratory system, but its current treatment has certain shortcomings and adverse effects. In this study, we evaluate the antifibrotic activity of pterostilbene (PTE) using an in vitro IPF model induced by transforming growth factor (TGF)-β1. Methods A549 and alveolar epithelial cells (AECs) were incubated with 10 ng/ml TGF-β1 to induce lung fibroblast activation. T… Show more

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Cited by 8 publications
(5 citation statements)
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“…Therefore, reversing the EMT may provide a strategy for inhibiting the metastasis of cancers. Transforming growth factor-beta 1 (TGF-β1) has a crucial role in chronic inflammation in various tissues, and is a strong promotor of EMT [ 23 , 24 ]. TGF-β1 regulates migration and invasion through loss of epithelial markers and gain of mesenchymal makers.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, reversing the EMT may provide a strategy for inhibiting the metastasis of cancers. Transforming growth factor-beta 1 (TGF-β1) has a crucial role in chronic inflammation in various tissues, and is a strong promotor of EMT [ 23 , 24 ]. TGF-β1 regulates migration and invasion through loss of epithelial markers and gain of mesenchymal makers.…”
Section: Discussionmentioning
confidence: 99%
“…Importantly, these myofibroblasts are critical players in developing IPF, because they maintain high-rate proliferation, invasion, migration, and excessive aberrant ECM production [73,74]. Therefore, the inhibition of EMT with various drugs has been widely studied for its beneficial effects in sufficiently ameliorating pulmonary fibrosis [75,76].…”
Section: Discussionmentioning
confidence: 99%
“…The PTE has been largely investigated for its’ anti-inflammation ( 53 ), anticancer ( 54 ), antiobesity ( 55 ), and antifibrosis effects ( 56 ) in the past decade. The PTE reduces blood pressure in adults at 250 mg/day doses ( 57 ).…”
Section: Discussionmentioning
confidence: 99%