Pterostilbene protects against uraemia serum-induced endothelial cell damage via activation of Keap1/Nrf2/HO-1 signaling

Chen, Zhiwei; Miu, Hai-Feng; Wang, Huiping; Wu, Zhi-Niu; Wang, Wen‐Juan; Ling, Yu-Jing; Xu, Xiaohui; Sun, Hai-Jian; Jiang, Xia

doi:10.1007/s11255-017-1734-4

Cited by 21 publications

(8 citation statements)

References 49 publications

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“…Moreover, Chen et al. have shown that PTS could effectively inhibit vascular endothelial cell dysfunction by inhibiting ROS/RNS and inflammatory response, which was related to the inhibition of Keap1‐Nrf2/HO‐1 signaling pathway to some extent . Results from in vitro and in vivo experiments by Sireesh et al.…”

Section: Natural Polyphenols Nrf2 Activators In Multiple Disease Modelsmentioning

confidence: 99%

“…[74] Moreover, Chen et al have shown that PTS could effectively inhibit vascular endothelial cell dysfunction by inhibiting ROS/RNS and inflammatory response, which was related to the inhibition of Keap1-Nrf2/HO-1 signaling pathway to some extent. [75] Results from in vitro and in vivo experiments by Sireesh et al showed that PTS improved beta cell function and survival against cytokine stress and prevented streptozotocin (STZ)-induced diabetes. [34] This study provides a further understanding of whether this naturally occurring compound can be used as Nrf2 activators and lays the foundation for clinical studies.…”

Section: Resveratrol and Its Analogsmentioning

confidence: 99%

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Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Zhou

Jiang

et al. 2019

Chemistry & Biodiversity

148

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The Keap1‐Nrf2/ARE signaling pathway is an important defense system against exogenous and endogenous oxidative stress injury. The dysregulation of the signaling pathway is associated with many diseases, such as cancer, diabetes, and respiratory diseases. Over the years, a wide range of natural products has provided sufficient resources for the discovery of potential therapeutic drugs. Among them, polyphenols possess Nrf2 activation, not only inhibit the production of ROS, inhibit Keap1‐Nrf2 protein–protein interaction, but also degrade Keap1 and regulate the Nrf2 related pathway. In fact, with the continuous improvement of natural polyphenols separation and purification technology and further studies on the Keap1‐Nrf2 molecular mechanism, more and more natural polyphenols monomer components of Nrf2 activators have been gradually discovered. In this view, we summarize the research status of natural polyphenols that have been found with apparent Nrf2 activation and their action modes. On the whole, this review may guide the design of novel Keap1‐Nrf2 activator.

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Section: Natural Polyphenols Nrf2 Activators In Multiple Disease Modelsmentioning

confidence: 99%

Section: Resveratrol and Its Analogsmentioning

confidence: 99%

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Zhou

Jiang

et al. 2019

Chemistry & Biodiversity

148

View full text Add to dashboard Cite

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“…Resveratrol has received considerable attention because of its accessibility to the general population and potential health benefits, such as anti‐inflammatory, antioxidant, and chemopreventive properties (Liu et al, ). The activation of Nrf2 and its target genes is postulated to be a key event in the biological activity of resveratrol (Chen et al, ). Resveratrol‐induced autophagy has been suggested to exert beneficial effects of resveratrol (Park et al, ).…”

Section: Introductionmentioning

confidence: 99%

Modulation of autophagy in the protective effect of resveratrol on PM2.5‐induced pulmonary oxidative injury in mice

et al. 2018

Phytotherapy Research

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Ambient fine particulate matter (PM2.5) is capable of inducing pulmonary oxidative injury. Autophagy maintains basal cellular homeostasis and plays a critical role in the pathogenesis of lung diseases. Resveratrol, a natural polyphenol, is an effective antioxidant agent against particulate matter (PM)-induced injuries. The current study was designed to investigate whether resveratrol can regulate autophagy in the process of PM2.5-mediated pulmonary oxidative injury. In the mice model of PM2.5 exposure, we found that PM2.5 increased the contents of malondialdehyde (MDA) and nitric oxide (NO) while decreased the expression of nuclear factor erythroid-2-related factor 2 in the lungs. The levels of 8-hydroxydeoxyguanosine and inflammatory cytokines were increased following PM2.5 exposure. Histological analysis of the lungs revealed inflammatory change in PM2.5 group. Meanwhile, PM2.5 triggered autophagy, as evidenced by the elevated expression of microtubule-associated proteins light chain 3II, Beclin1 and p62. Transmission electron microscopy images showed that autophagosomes accumulated in the lungs after PM2.5 exposure. Furthermore, resveratrol intervention suppressed autophagy and attenuated the oxidative injury resulting from PM2.5 exposure. Our findings provided a valuable insight into the underlying mechanism for the protective effects of resveratrol against PM2.5-induced lung injury, which involves suppression of the autophagic process. KEYWORDS autophagy, lung, oxidative injury, PM2.5, resveratrol * Yuan Li and Suming Fu contributed equally to this work.

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“…Pterostilbene was found to increase protein expression of Nrf2 in cardiac tissues, which may account for the prevention of cardiac oxidative stress and inflammation in fructose-fed rats ( 32 ). Chen et al ( 33 ) showed that pterostilbene protects against uremia serum-induced endothelial cell damage via activation of the Keap1/Nrf2/HO-1 signaling pathway. The present study found that treatment with pterostilbene increased Nrf2, while Nrf2 knockdown canceled the pterostilbene-mediated inhibition of endothelial cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Pterostilbene reduces endothelial cell apoptosis by regulation of the Nrf2‑mediated TLR‑4/MyD88/NF‑κB pathway in a rat model of atherosclerosis

et al. 2020

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Endothelial cell injury in vascular arterial walls plays a crucial role in the pathological process of atherosclerosis. Pterostilbene, a stilbenoid chemically related to resveratrol, has anti-inflammatory, anti-apoptosis and antioxidant properties. However, the underlying mechanisms mediated by pterostilbene in regards to endothelial cell injury in vascular arterial walls are not fully understood. The purpose of the present study was to investigate the benefits of pterostilbene in a rat model of atherosclerosis. The possible mechanism of pterostilbene was also analyzed in regards to endothelial cell injury in vascular arterial walls in vitro. A rat model of atherosclerosis was established using endothelial injury of the iliac arteries. CCK-8 assay, TUNEL, immunofluorescence, western blot analysis and hematoxylin and eosin (H&E) staining were used to analyze the role of pterostilbene in the pathological processes of atherosclerosis. In vivo results showed that pterostilbene decreased cholesterol (CHO), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) in plasma and attenuated interleukin (IL)-1, tumor necrosis factor (TNF)-α and IL-6 and oxidative stress injury in serum in the experimental animals. Pterostilbene treatment reduced atherogenesis, aortic plaques, macrophage infiltration and apoptosis of vascular arterial walls in the atherosclerosis rat model. In vitro assay demonstrated that pterostilbene administration increased viability of the endothelial cells, attenuated oxidative stress injury and apoptosis of endothelial cells. The results found that pterostilbene regulated endothelial cell apoptosis via the Nrf2-mediated TLR-4/MyD88/NF-κB pathway. In conclusion, data from the present study revealed that pterostilbene protects rats against atherosclerosis by regulation of the Nrf2-mediated TLR-4/MyD88/NF-κB pathway.

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Pterostilbene protects against uraemia serum-induced endothelial cell damage via activation of Keap1/Nrf2/HO-1 signaling

Cited by 21 publications

References 49 publications

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Modulation of autophagy in the protective effect of resveratrol on PM2.5‐induced pulmonary oxidative injury in mice

Pterostilbene reduces endothelial cell apoptosis by regulation of the Nrf2‑mediated TLR‑4/MyD88/NF‑κB pathway in a rat model of atherosclerosis

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