Pterygia With Deep Corneal Changes

Mootha, Venkateswara; Pingree, Michael; Jaramillo, J.

doi:10.1097/01.ico.0000121701.74077.78

Cited by 28 publications

(37 citation statements)

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“…10,16 In limited cases, the average central endothelial density of the involved cornea showed a significantly greater decrease than that of the unaffected eyes. 17 In this study, there was a significant association between a decrease in the ECD and an increase in the percentage of pterygium to cornea, and a logarithmic correlation was observed. A self-limiting phenomenon in the percentage of ECD loss resulting from pterygium extension may exist.…”

Section: Discussionmentioning

confidence: 71%

Pterygium Is Related to a Decrease in Corneal Endothelial Cell Density

Hsu

Lee

Liang

et al. 2014

Cornea

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Section: Discussionmentioning

confidence: 71%

Pterygium Is Related to a Decrease in Corneal Endothelial Cell Density

Hsu

Lee

Liang

et al. 2014

Cornea

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“…Our observations are also consistent with the finding that the presence of a pterygium can be associated with deep corneal changes at the level of the endothelium and Descemet membrane and that endothelial cell density may be lower in these eyes. 47 Furthermore, limbal focusing may also affect corneal nerves as they cross the limbus, allowing the possibility of neuropeptide involvement in pterygium pathogenesis and explaining corneal sensory alterations in pterygium patients. 48 If corneal nerves are implicated, their radial distribution may also help to explain pterygium shape.…”

Section: Peripheral Light Focusing and Pterygium Pathogenesismentioning

confidence: 99%

Ultraviolet Radiation and the Anterior Eye

Coroneo

2011

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

116

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The eye is on the one hand dependent on visible light energy and on the other hand can be damaged by these and the contiguous ultraviolet (UV) and infrared wavelengths. Diseases of the eye in which sunlight has been implicated have been termed the ophthalmohelioses, and these conditions pose a significant problem to the eye health of many communities. The ophthalmohelioses have a tremendous impact on patients' quality of life and have significant implications on the cost of health care. Although cataract is not entirely caused by insolation, it now seems certain that sunlight plays a contributory role-cataract extraction is one of the, if not the most, commonly performed surgical procedures in many societies. Pterygium, typically afflicting a younger population, adds a tremendous burden, both human and financial, in many countries. We review evidence that peripheral light focusing by the anterior eye to the sites of usual locations of pterygium and cataract plays a role in the pathogenesis of these conditions. Recognition of the light pathways involved with foci at stem cell niches has directed our investigations into inflammatory and matrix metalloproteinase-related pathophysiologic mechanisms. An understanding of the intracellular mechanisms involved has provided some insight into how medical treatments have been developed for the effective management of ocular surface squamous neoplasia. The concept of peripheral light focusing has also provided direction in the prevention of these diseases. This has resulted in improved sunglass design and the further development of UV-blocking contact lenses. With the development of ocular UV fluorescence photographic techniques, we have been able to demonstrate preclinical ocular surface evidence of solar damage. Evidence that diet may play a role in the development of certain conditions is reviewed. The conundrum of the public health message about solar exposure is also reviewed, and in this context, the potential role of vitamin D deficiency is summarized. The eye may play a role in the development of individualized assessment techniques of solar damage, perhaps allowing us to provide better advice to both individuals and populations.

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“…13 Mootha et al demonstrated deep corneal marks at the level of the endothelium and descement membrane in patients with long-standing pterygium. 6 However, recently no investigators have reported the effects of the pterygium surgery on the anterior chamber parameters in addition to the changes in visual acuity and corneal topography.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 The induction of astigmatism due to the invasion of the pterygium into the cornea has been reported by numerous studies. [6][7][8][9][10] The pterygia can decrease vision by occluding the visual axis or by inducing with-the-rule astigmatism with locally flattening the cornea. [6][7][8][9][10] In addition, pterygia can lead to the deterioration of the quality of visual performance by increasing the ocular wavefront aberrations.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8][9][10] The pterygia can decrease vision by occluding the visual axis or by inducing with-the-rule astigmatism with locally flattening the cornea. [6][7][8][9][10] In addition, pterygia can lead to the deterioration of the quality of visual performance by increasing the ocular wavefront aberrations. Therefore patients with pterygium may have significant visual symptoms despite visual axis sparing and appreciated spectacle correction.…”

Section: Introductionmentioning

confidence: 99%

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