PTH-125 The clinical utility and diagnostic accuracy of faecal calprotectin for IBD in paediatric patients

Soubières, Anet; Shandro, Benjamin; Mathur, J. B. L.; Boa, Frances; Paul, Thankam; Poullis, Andrew

doi:10.1136/gutjnl-2019-bsgabstracts.184

Cited by 2 publications

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“…продемонстрували, що S100A8 і S100A9 регулюють програмування кишкового імунітету, а високий рівень КП у фекаліях новонароджених пов'язаний з колонізацією кишечника сприятливою мікробіотою. Тому концентрацію фекального КП у педіатричних пацієнтів слід тлумачити з обережністю [34].…”

Section: фекальний кальпротектин у здорових осіб та за наявності захв...unclassified

Biological functions and clinical significance of calprotectin. Review

Tkach¹,

Dorofeev²,

Kharchenko³

et al. 2022

СГ

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Recently, in addition to clinical, endoscopic and morphological studies, the algorithm for the diagnosis of inflammatory bowel disease (IBD) also includes some serum and fecal biomarkers that help select patients for endoscopy, as well as distinguish between organic and functional (non‑inflammatory) diseases (for example, irritable bowel syndrome). Among the latter, the definition of fecal calprotectin (CP) is used mostly often, it is a well‑studied biomarker of inflammation due to its stability, reproducibility of analysis, low cost, and high diagnostic value. The presented review highlights the latest data on the main biological CP functions and the clinical application of its definition in inflammatory diseases of intestine, skin, joints, etc. It is shown that CP belongs to the family of calcium‑binding leukocyte S100 proteins and consists of two monomers: S100A8 and S100A9. CP is constitutively expressed by monocytes, dendritic cells, activated macrophages, keratinocytes of the oral cavity and squamous epithelium of the mucosa. Thus, the CP expression in a healthy person is limited by a small number of specialized cells and is usually activated during inflammation. Both subunits of CP, S100A8 and S100A9, have a wide range of intracellular and extracellular immunomodulatory properties, control the intracellular pathways of innate immune cells and are responsible for organizing the response to the inflammatory process. Determination of fecal CP enables distinguishing between non‑inflammatory and inflammatory bowel diseases, it is a non‑invasive inexpensive method, and the CP itself remains stable at room temperature in the feces for at least 3 days. In the diagnosis of IBD, fecal CP is a more sensitive marker than C‑reactive protein, which has made it an excellent (i.e., highly sensitive) biomarker for detecting intestinal inflammation in IBD and has contributed to its widespread use worldwide. The value of the level of fecal Cp < 40 mg/g can reliably exclude IBD, and a value > 250 mg/g dictates the need for endoscopic examination of the patient for IBD or raises the suspicion of its recurrence.

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Section: фекальний кальпротектин у здорових осіб та за наявності захв...unclassified

Biological functions and clinical significance of calprotectin. Review

Tkach¹,

Dorofeev²,

Kharchenko³

et al. 2022

СГ

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Calprotectin: from biomarker to biological function

Jukic

Bakiri

Wagner

et al. 2021

Gut

283

138

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The incidence of inflammatory bowel diseases (IBD) emerged with Westernisation of dietary habits worldwide. Crohn’s disease and ulcerative colitis are chronic debilitating conditions that afflict individuals with substantial morbidity and challenge healthcare systems across the globe. Since identification and characterisation of calprotectin (CP) in the 1980s, faecal CP emerged as significantly validated, non-invasive biomarker that allows evaluation of gut inflammation. Faecal CP discriminates between inflammatory and non-inflammatory diseases of the gut and portraits the disease course of human IBD. Recent studies revealed insights into biological functions of the CP subunits S100A8 and S100A9 during orchestration of an inflammatory response at mucosal surfaces across organ systems. In this review, we summarise longitudinal evidence for the evolution of CP from biomarker to rheostat of mucosal inflammation and suggest an algorithm for the interpretation of faecal CP in daily clinical practice. We propose that mechanistic insights into the biological function of CP in the gut and beyond may facilitate interpretation of current assays and guide patient-tailored medical therapy in IBD, a concept warranting controlled clinical trials.

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PTH-125 The clinical utility and diagnostic accuracy of faecal calprotectin for IBD in paediatric patients

Cited by 2 publications

References 0 publications

Biological functions and clinical significance of calprotectin. Review

Biological functions and clinical significance of calprotectin. Review

Calprotectin: from biomarker to biological function

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