PTHrP intracrine actions divergently influence breast cancer growth through p27 and LIFR
Courtney M. Edwards,
Jeremy F. Kane,
Jailyn A. Smith
et al.
Abstract:The role of parathyroid hormone (PTH)-related protein (PTHrP) in breast cancer remains controversial, with reports of PTHrP inhibiting or promoting primary tumor growth in preclinical studies. Here, we provide insight into these conflicting findings by assessing the role of specific biological domains of PTHrP in tumor progression through stable expression of PTHrP (-36-139aa) or truncated forms with deletion of the nuclear localization sequence (NLS) alone or in combination with the C-terminus. Although the f… Show more
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