Background: Firefighting is a hazardous occupation exposure to a wide range of toxic chemicals, smoke, and other contaminant that is associated with many occupational health risks. As a result, there has been growing concern over the potential health effects of this exposure, including an increased risk of cancer, respiratory problems, and cardiac events. Objective: This systematic review aims to investigate the occupational health situation of firefighters, in the last 10 years. Method: Research via electronic databases: PubMed, Web of Science and ScienceDirect was conducted keywords related to occupational exposure, diseases, and firefighting. Results: A total of 20 studies that examined the association between occupational exposure and the incidence or prevalence of diseases were included in analysis. Conclusion: Despite ongoing research, the exact magnitude of the risks associated with occupational exposure for firefighters is still unclear. However, there is evidence to suggest that the risk of these occupational diseases increases with length of service and intensity of exposure to firefighting contaminants. Therefore, it is essential to develop effective measures to prevent and manage these risks to ensure the health and well-being of firefighters.