PTSD, Immune System, and Inflammation

Pivac, Nela; Vuić, Barbara; Šagud, Marina; Erjavec, Gordana Nedić; Perković, Matea Nikolac; Konjevod, Marcela; Tudor, Lucija; Štrac, Dubravka Švob; Uzun, Suzana; Kozumplik, Oliver; Uzun, Sandra; Mímica, Ninoslav

doi:10.1007/978-981-19-7376-5_11

Cited by 9 publications

(3 citation statements)

References 235 publications

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“…HBOT has been demonstrated to have wide-ranging effects on inflammation and a dysregulated immune system ( 54 – 59 ) that may be due to its broad effects on expression and suppression of immune-active genes ( 60 – 62 ). The anatomic and functional imaging findings ( 11 – 21 ) and immune dysregulation in PTSD ( 19 , 63 ) imply that the experience of a terrifying traumatic event triggers wounding and inflammatory changes in the brain. The structural and functional imaging changes documented in the reviewed studies ( 35 , 36 , 44 , 45 ) suggest that the HBOT-generated improvement in PTSD symptoms are the result of HBOT’s well-documented effects on wound pathophysiology and wound-healing.…”

Section: Discussionmentioning

confidence: 99%

Systematic review and dosage analysis: hyperbaric oxygen therapy efficacy in the treatment of posttraumatic stress disorder

Andrews,

Harch

2024

Front. Neurol.

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BackgroundStudies of hyperbaric oxygen therapy (HBOT) treatment of mild traumatic brain injury persistent postconcussion syndrome in military and civilian subjects have shown simultaneous improvement in posttraumatic stress disorder (PTSD) or PTSD symptoms, suggesting that HBOT may be an effective treatment for PTSD. This is a systematic review and dosage analysis of HBOT treatment of patients with PTSD symptoms.MethodsPubMed, CINAHL, and the Cochrane Systematic Review Database were searched from September 18 to November 23, 2023, for all adult clinical studies published in English on HBOT and PTSD. Randomized trials and studies with symptomatic outcomes were selected for final analysis and analyzed according to the dose of oxygen and barometric pressure on symptom outcomes. Outcome assessment was for statistically significant change and Reliable Change or Clinically Significant Change according to the National Center for PTSD Guidelines. Methodologic quality and bias were determined with the PEDro Scale.ResultsEight studies were included, all with < 75 subjects/study, total 393 subjects: seven randomized trials and one imaging case-controlled study. Six studies were on military subjects, one on civilian and military subjects, and one on civilians. Subjects were 3-450 months post trauma. Statistically significant symptomatic improvements, as well as Reliable Change or Clinically Significant changes, were achieved for patients treated with 40-60 HBOTS over a wide range of pressures from 1.3 to 2.0 ATA. There was a linear dose-response relationship for increased symptomatic improvement with increasing cumulative oxygen dose from 1002 to 11,400 atmosphere-minutes of oxygen. The greater symptomatic response was accompanied by a greater and severe reversible exacerbation of emotional symptoms at the highest oxygen doses in 30-39% of subjects. Other side effects were transient and minor. In three studies the symptomatic improvements were associated with functional and anatomic brain imaging changes. All 7 randomized trials were found to be of good-highest quality by PEDro scale scoring.DiscussionIn multiple randomized and randomized controlled clinical trials HBOT demonstrated statistically significant symptomatic improvements, Reliable Changes, or Clinically Significant Changes in patients with PTSD symptoms or PTSD over a wide range of pressure and oxygen doses. The highest doses were associated with a severe reversible exacerbation of emotional symptoms in 30-39% of subjects. Symptomatic improvements were supported by correlative functional and microstructural imaging changes in PTSD-affected brain regions. The imaging findings and hyperbaric oxygen therapy effects indicate that PTSD can no longer be considered strictly a psychiatric disease.

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Section: Discussionmentioning

confidence: 99%

Systematic review and dosage analysis: hyperbaric oxygen therapy efficacy in the treatment of posttraumatic stress disorder

Andrews,

Harch

2024

Front. Neurol.

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“…Chronic stress exerts a negative influence on immune function through neurotransmitters such as epinephrine and norepinephrine (29). The proportion of immune cells and levels of inflammatory factors in peripheral blood of people exposed to a severe stress were different from those of the general population (5,30). However, cancer is one of the immune associated diseases and immune dysfunction influences tumor behaviors.…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of the association between post-traumatic stress disorder and cancer risk

Yang,

Jiang

2023

Front. Psychiatry

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BackgroundSeveral studies have investigated the link between post-traumatic stress disorder (PTSD) and cancer risk but reported mixed results. The objective of our study was to investigate the association between PTSD and cancer risk.MethodsStudies published in English about the relationship between PTSD and cancer incidence were systematically searched. We performed a meta-analysis to estimate the relative risks (RR) and 95% confidence intervals (CI) for cancer incidence.ResultA total of 3,129 articles were screened. Finally, 8 articles and 11 studies were included in the meta-analysis. We found that PTSD was not associated with cancer risk compared with controls. For site-specific cancer, our results showed that women with PTSD were associated with higher risk of ovarian cancer than controls. However, PTSD was not associated with the risk of gastrointestinal cancer, breast cancer and lung cancer.ConclusionThese analyzes based on studies published in English suggest that PTSD is associated with ovarian cancer risk, although the evidence base is very limited. Future studies are needed to investigate the mechanisms that PTSD diagnosis influenced cancer incidence depending on types of cancer.

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“…У хворих терапевтичного профілю найбільш несприятливим слід вважати поєднання та/або приєднання так званих «хвороб цивілізації» -АГ, ожиріння, ЦД 2-го типу до різноманітних реакцій на стрес або РА, що знаходить відображення у численних закордонних публікаціях [16][17][18][19][20][21][22]. Значну увагу цьому питанню при-діляли і відомі українські терапевти, ендокринологи та кардіологи [23][24][25].…”

Section: ) пролонгована депресивна реакція (F4321) змішана тривожна і...unclassified

Adjustment disorders, hypertension and type 2 diabetes: a cardiologist’s view (literature review)

Miloslavsky,

Koval

2023

Mìžnarodnij endokrinologìčnij žurnal

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The role of the stress factor and adjustment disorders among patients of a very high-risk group, namely with hypertension against the background of type 2 diabetes, was examined in the review of domestic and foreign sources of literature from the PubMed database. The authors provide data on the classification and terminology of adjustment disorders in this category of patients, and the contribution of the stress factor and activation of neurohumoral systems in their formation is considered in the historical aspect. The issue of the role of such adjustment disorders as anxiety, depression, sleep disorders, violent behavior in the family, at work is considered separately in terms of the negative course and progression of these dangerous diseases. Data are given on a number of non-modifiable and modifiable risk factors, namely genetic, haemodynamic, neurohumoral, hormonal and cardiometabolic characteristics of patients, prevalence, morbidity and mortality from complications of hypertension and type 2 diabetes in the presence of adjustment disorders; a brief description of diagnostic and preventive approaches to the correction of adjustment disorders among patients at a very high risk are described from a cardiologist’s standpoint.

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PTSD, Immune System, and Inflammation

Cited by 9 publications

References 235 publications

Systematic review and dosage analysis: hyperbaric oxygen therapy efficacy in the treatment of posttraumatic stress disorder

Systematic review and dosage analysis: hyperbaric oxygen therapy efficacy in the treatment of posttraumatic stress disorder

A meta-analysis of the association between post-traumatic stress disorder and cancer risk

Adjustment disorders, hypertension and type 2 diabetes: a cardiologist’s view (literature review)

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