PTU-227 Statins may modify colorectal anastomotic leak risk in high risk patients

Battersby, Clf; Green, P; Vyapury, V; Rooney, P. S.; Hunt, Judith M.

doi:10.1136/gutjnl-2015-309861.342

Cited by 7 publications

(4 citation statements)

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“…15,16,20 However, other studies have not found any postoperative benefit of such therapy. [17][18][19] Despite finding no difference in postoperative complications, a prospective study performed by Singh et al demonstrated reduced C-reactive protein, IL-6, IL-8, and TNF-α levels in plasma and lower peritoneal concentrations of IL-6 and IL-8 following colorectal surgery in statin-naïve patients receiving perioperative statin therapy for a maximum duration of 3 weeks. 13 In a propensityscored cohort of 3572 patients subjected to colorectal cancer surgery, Disbrow et al found that statin users had a significant reduction in the postoperative rate of sepsis (3.75% versus 5.32%, p = 0.03).…”

Section: Discussionmentioning

confidence: 99%

“…14 Studies evaluating the protective effects of statins in colorectal surgery are contradictory, and agreement is lacking about whether this group of drugs has any potential beneficial effect on postoperative outcomes. 13,[15][16][17][18][19][20] Thus, this study aims to assess the association between regular perioperative statin therapy and postoperative mortality following elective colon cancer surgery using a large national sample.…”

Section: Introductionmentioning

confidence: 99%

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Statin Therapy Is Associated With Decreased 90-Day Postoperative Mortality After Colon Cancer Surgery

Pourlotfi

Hulme

Bass

et al. 2022

Diseases of the Colon &Amp; Rectum

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BACKGROUND:There have been conflicting reports regarding a protective effect of statin therapy after colon cancer surgery.OBJECTIVE: This study aimed to evaluate the association between statin therapy and the postoperative mortality following elective colon cancer surgery. DESIGN:This population-based cohort study is a retrospective analysis of prospectively collected data from the Swedish Colorectal Cancer Register. SETTINGS:Patient inclusion was achieved through a nationwide register. PATIENTS:All adult patients undergoing elective surgery for colon cancer between January 2007 and September 2016 were included in the study. Patients who had received and collected a prescription for statins pre-and postoperatively were allocated to the statin-positive cohort. MAIN OUTCOME MEASURES:The primary and secondary outcomes of interest were 90-day all-cause mortality and 90-day cause-specific mortality.RESULTS: A total of 22,337 patients underwent elective surgery for colon cancer during the study period, of whom 6,494 (29%) were classified as statin users. Statin users displayed a significant survival benefit despite being older, having a higher comorbidity burden, and being less fit for surgery. Multivariate analysis illustrated significant reductions in the incidence risk for 90-day allcause mortality (Incidence Rate Ratio = 0.12, p < 0.001) as well as 90-day cause-specific deaths due to sepsis, due to multiorgan failure, or resulting from a cardiovascular and respiratory origin. LIMITATIONS:The limitations of this study include its observational retrospective design, restricting the ability to perform standardized follow-up of statin therapy. Confounding from other uncontrolled variables cannot be excluded. CONCLUSIONS:Statin users had a significant postoperative benefit regarding short-term mortality following elective colon cancer surgery in the current study; however, further research is needed to ascertain whether this relationship is causal. See Video Abstract at http://links.lww.com/DCR/B738.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Statin Therapy Is Associated With Decreased 90-Day Postoperative Mortality After Colon Cancer Surgery

Pourlotfi

Hulme

Bass

et al. 2022

Diseases of the Colon &Amp; Rectum

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“…Previous studies have investigated the potential impact of statin therapy on short‐term postoperative outcomes following colorectal surgery. While some have found postoperative benefits in the form of decreased complication rates, [12–14] others have not been able to demonstrate any association [15–17]. Data on statin therapy and postoperative mortality isolated to rectal resection surgery for cancer are scarce [12].…”

Section: Introductionmentioning

confidence: 99%

Statin therapy and postoperative short‐term mortality after rectal cancer surgery

et al. 2020

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“…Several studies have examined the effect of statins on perioperative physiology [ 11 , 12 , 13 , 14 , 15 , 16 ], with some demonstrating a positive association between statin use and improved short-term postoperative outcomes [ 11 , 12 ]. The authors previously reported a reduction in 90-day postoperative mortality after colon or rectal cancer surgery which was independently associated with premorbid statin use [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Statin Use and Long-Term Mortality after Rectal Cancer Surgery

Pourlotfi

Bass

Hulme

et al. 2021

Cancers

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Background: The current study aimed to assess the association between regular statin therapy and postoperative long-term all-cause and cancer-specific mortality following curative surgery for rectal cancer. The hypothesis was that statin exposure would be associated with better survival. Methods: Patients with stage I–III rectal cancer undergoing surgical resection with curative intent were extracted from the nationwide, prospectively collected, Swedish Colorectal Cancer Register (SCRCR) for the period from January 2007 and October 2016. Patients were defined as having ongoing statin therapy if they had filled a statin prescription within 12 months before and after surgery. Cox proportional hazards models were employed to investigate the association between statin use and postoperative five-year all-cause and cancer-specific mortality. Results: The cohort consisted of 10,743 patients who underwent a surgical resection with curative intent for rectal cancer. Twenty-six percent (n = 2797) were classified as having ongoing statin therapy. Statin users had a considerably decreased risk of all-cause (adjusted hazard ratio (HR) 0.66, 95% confidence interval (CI): 0.60–0.73, p < 0.001) and cancer-specific (adjusted HR 0.60, 95% CI: 0.47–0.75, p < 0.001) mortality up to five years following surgery. Conclusions: Statin use was associated with a lower risk of both all-cause and rectal cancer-specific mortality following curative surgical resections for rectal cancer. The findings should be confirmed in future prospective clinical trials.

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PTU-227 Statins may modify colorectal anastomotic leak risk in high risk patients

Cited by 7 publications

References 0 publications

Statin Therapy Is Associated With Decreased 90-Day Postoperative Mortality After Colon Cancer Surgery

Statin Therapy Is Associated With Decreased 90-Day Postoperative Mortality After Colon Cancer Surgery

Statin therapy and postoperative short‐term mortality after rectal cancer surgery

Statin Use and Long-Term Mortality after Rectal Cancer Surgery

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