PTX3-Based Genetic Testing for Risk of Aspergillosis After Lung Transplant: Table 1.

Cunha, Cristina; Monteiro, Alexandre Amorim; Oliveira-Coelho, Ana; Kühne, Juliana; Rodrigues, Fernando; Sasaki, Sergio D.; Schio, Sadi Marcelo; Camargo, José J.; Mantovani, Alberto; Carvalho, Agostinho; Pasqualotto, Alessandro C.

doi:10.1093/cid/civ679

Cited by 47 publications

(41 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the light of our results on PTX3, genetically-targeted antifungal prophylaxis would be particularly useful in patients with intensive chemotherapy for AL in which universal prophylaxis is not always made, although IA remains more frequent than in SOT patients (11,12).…”

mentioning

confidence: 91%

“…Previous studies showed robust associations between these SNPs and IMIs among both HSCT (9, 10) and SOT recipients (11,12). The strength of theses associations, together with relative high allele frequency of the SNPs and replication among different at-risk population have made PTX3 SNPs the most reliable marker of IMIs in these populations.…”

mentioning

confidence: 95%

“…Single nucleotide polymorphisms (SNPs) leading to PTX3 deficiency have been identified as strong predictors of invasive aspergillosis (IA) in allogeneic hematopoietic stem cells transplant ( HSCT) (9,10) and solid organ transplant (SOT) recipients (11,12). In the present study, we investigated the role of two PTX3 SNPs for susceptibility to IMIs in AL patients with intensive chemotherapy.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Pentraxin-3 polymorphisms and invasive mold infections in acute leukemia patients receiving intensive chemotherapy

Brunel¹,

Wójtowicz²,

Lamoth³

et al. 2018

Haematologica

View full text Add to dashboard Cite

mentioning

confidence: 91%

mentioning

confidence: 95%

mentioning

confidence: 99%

See 1 more Smart Citation

Pentraxin-3 polymorphisms and invasive mold infections in acute leukemia patients receiving intensive chemotherapy

Brunel¹,

Wójtowicz²,

Lamoth³

et al. 2018

Haematologica

View full text Add to dashboard Cite

“…Interestingly, PTX3 polymorphisms were recently associated with susceptibility to A. fumigatus infection in two cohorts of patients undergoing bone marrow transplantation [37]. The association between genetic polymorphisms and susceptibility to mold infections was recently independently confirmed in 1101 patients of the Swiss Organ Transplantation Cohort [38] and in a small cohort of lung transplantation patients [39].…”

Section: Protective Role Of Ptx3 In Pathogen Defencementioning

confidence: 94%

Pentraxins and Collectins: Friend or Foe during Pathogen Invasion?

Foo

Reading

Jaillon

et al. 2015

Trends in Microbiology

Self Cite

View full text Add to dashboard Cite

Innate immunity serves as the frontline defence against invading pathogens. Despite decades of research, new insights are constantly challenging our understanding of host-elicited immunity during microbial infections. Recently, two families of humoral innate immune proteins, pentraxins and collectins, have become a major focus of research in the field of innate immunity. Pentraxins and collectins are key players in activating the humoral arm of innate immunity, taking centre stage in immunoregulation and disease modulation. However, increasing evidence suggests that pentraxins and collectins can also mediate pathogenic effects during some infections. Herein, we discuss the protective and pathogenic effects of pentraxins and collectins, as well as their therapeutic significance.

show abstract

“…29 The same haplotype was associated with IA in 2 cohorts of solid organ transplant recipients. 37,38 PTX3 encodes long pentraxin 3, a soluble PRR that detects galactomannan from the fungi. PTX3 induces many immune processes such as pathogen opsonization, phagocytosis, complement activation, as well as clearance of apoptotic cells.…”

Section: Infectious Complications and Risk Assessment Of Hsct Recipientsmentioning

confidence: 99%

Risk stratification and immunogenetic risk for infections following stem cell transplantation

Wójtowicz

Bochud

2016

Virulence

View full text Add to dashboard Cite

Patients undergoing haematopoietic stem cell transplantation (HSCT) are highly exposed to infectious agents. However, it is not known why certain HSCT recipients rapidly develop severe infections while other, despite similar immunosuppressive conditions, do not. Increasing evidence suggests that such differences may be due, in part, to polymorphisms in immune genes. Thus, the identification of genetic factors influencing susceptibility to infections in HSCT recipients may lead to the development of individualized management strategies. However, studies are challenged by several issues, including the relative small size of existing cohorts, the frequent use of prophylactic or preemptive antimicrobial agents, and the fact that genes responsible for immune functions can be inherited either from the donor or the host. Consequently, the major challenge for today's researchers is to overcome these limitations and find associations that are robust enough to be translated into reliable risk stratification strategies for infectious diseases.

show abstract

PTX3-Based Genetic Testing for Risk of Aspergillosis After Lung Transplant: Table 1.

Abstract: Potential conflicts of interest. A. M. has been a consultant to Sigma Tau Pharmaceuticals (Pomezia, Italy) and a board member of the Istituto di Ricerche in Biomedicina (Bellinzona, Switzerland) and Efranat Ltd (Rehovot, Israel). A. M. has

Cited by 47 publications

References 8 publications

Pentraxin-3 polymorphisms and invasive mold infections in acute leukemia patients receiving intensive chemotherapy

Pentraxin-3 polymorphisms and invasive mold infections in acute leukemia patients receiving intensive chemotherapy

Pentraxins and Collectins: Friend or Foe during Pathogen Invasion?

Risk stratification and immunogenetic risk for infections following stem cell transplantation

Contact Info

Product

Resources

About