Pubertal exposure to bisphenol A disrupts behavior in adult C57BL/6J mice

Yu, Chengjun; Tai, Fadao; Song, Zhenzhen; Wu, Ruiyong; Zhang, Xia; He, Fengqin

doi:10.1016/j.etap.2010.09.009

Cited by 43 publications

(29 citation statements)

References 62 publications

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“…The mice exposed to high BPA doses experienced significant changes in social behavior, anxiety and aggression (Kundakovic et al, 2013). Additional studies have shown that rodents exposed to BPA prenatally had increased levels of anxiety (Cox et al, 2010; Luo et al, 2014; Patisaul and Bateman, 2008; Ryan and Vandenbergh, 2006; Tian et al, 2010; Xu et al, 2014; Xu et al, 2011; Yu et al, 2011), aggression (Patisaul and Bateman, 2008), and hyperactivity (although the sex-specificity of these associations was not consistent between studies) (Ishido et al, 2004; Ishido et al, 2007; Masuo et al, 2004; Xu et al, 2007), and a loss of sexual dimorphism for spatial learning and memory outcomes (Ryan and Vandenbergh, 2006; Xu et al, 2007; Xu et al, 2011). Taken together, these studies suggest that epigenetic mechanisms may underlie the effects of BPA on behavior; however, data are lacking in humans.…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A exposure and behavioral problems among inner city children at 7–9 years of age

Roen

Wang

Calafat

et al. 2015

Environmental Research

142

102

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Background Bisphenol A (BPA) is a ubiquitous endocrine disrupting compound. Several experimental and epidemiological studies suggest that gestational BPA exposure can lead to neurodevelopmental and behavioral problems in early-life, but results have been inconsistent. We previously reported that prenatal BPA exposure may affect child behavior and differently among boys and girls at ages 3-5 years. Objectives We investigated the association of prenatal and early childhood BPA exposure with behavioral outcomes in 7-9 year old minority children and hypothesized that we would observe the same sex-specific pattern observed at earlier ages. Methods African-American and Dominican women enrolled in an inner-city prospective cohort study and their children were followed from mother’s pregnancy through children’s age 7-9 years. Women during the third trimester of pregnancy and children at ages 3 and 5 years provided spot urine samples. BPA exposure was categorized by tertiles of BPA urinary concentrations. The Child Behavioral Checklist (CBCL) was administered at ages 7 and 9 to assess multiple child behavior domains. Associations between behavior and prenatal (maternal) BPA concentrations and behavior and postnatal (child) BPA concentration were assessed via Poisson regression in models stratified by sex. These models accounted for potential confounders including prenatal or postnatal urinary BPA concentrations, child age at CBCL assessment, ethnicity, gestational age, maternal intelligence, maternal education and demoralization, quality of child’s home environment, prenatal environmental tobacco smoke exposure, and prenatal mono-n-butyl phthalate concentration. Results The direction of the associations differed between boys and girls. Among boys (n=115), high prenatal BPA concentration (upper tertile vs. lower two tertiles) was associated with increased internalizing (β=0.41, p<0.0001) and externalizing composite scores (β=0.40, p<0.0001) and with their corresponding individual syndrome scales. There was a general decrease in scores among girls that was significant for the internalizing composite score (β= −0.17, p=0.04) (n=135). After accounting for possible selection bias, the results remained consistent for boys. Conversely, high postnatal BPA concentration was associated with increased behaviors on both the internalizing composite (β=0.30, p=0.0002) and externalizing composite scores (β=0.33, p<0.0001) and individual subscores in girls but fewer symptoms in boys. These results remained significant in girls after accounting for selection bias. Conclusion These results suggest BPA exposure may affect childhood behavioral outcomes in a sex-specific manner and differently depending on timing of exposure.

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Section: Discussionmentioning

confidence: 99%

Bisphenol A exposure and behavioral problems among inner city children at 7–9 years of age

Roen

Wang

Calafat

et al. 2015

Environmental Research

142

102

View full text Add to dashboard Cite

show abstract

“…3A and B). 169,171,174,[239][240][241][242][243][244][245][246][247] Considering factors such as age, sex, and hormonal status, numerous studies report similar effects in neurobehavioral assessments examining low doses of BPA. Furthermore, previous reports were convincing enough in 2008 for the NTP to conclude that based on experimental data, there was "some concern" that low doses of BPA could affect development of the brain and behaviors in humans.…”

Section: Integration Of Endpoints Across Levels Of Biological Organizmentioning

confidence: 93%

Low dose effects of bisphenol A

Vandenberg

Ehrlich

Belcher

et al. 2013

Endocrine Disruptors

187

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“…Toxicological studies reported that exposure to BPA during development causes brain problems, including memory deficits later in life, but the outcomes of exposure in adulthood are unclear. Recent studies examined the neurotoxic effects of BPA, and it has been reported to cause dose-dependent disturbances in behavior, learning and memory in rodents [20,63,71]. Other studies indicated that a single neonatal exposure to BPA can alter the adult levels of monoamine and neuroproteins important for normal brain development [44,64].…”

Section: Introductionmentioning

confidence: 97%