Pubertal growth and development and prenatal and lactational exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene

Gladen, Beth C.; Ragan, N. Beth; Rogan, Walter J.

doi:10.1016/s0022-3476(00)90012-x

Cited by 255 publications

(219 citation statements)

References 25 publications

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“…Delayed initiation of breast development was found in girls with higher prenatal dioxin exposure . In several other studies, no significant association was found between exposure to persistent chlorinated compounds and timing of puberty, in girls (Blanck et al, 2000;Gladen et al, 2000;Vasiliu et al, 2004) or in boys (Gladen et al, 2000;Mol et al, 2002).…”

Section: Discussionmentioning

confidence: 71%

Internal exposure to pollutants and sexual maturation in Flemish adolescents

Hond

Dhooge

Bruckers

et al. 2010

J Expo Sci Environ Epidemiol

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Flanders is densely populated with much industry and intensive farming. Sexual maturation of adolescents (aged 14-15 years) was studied in relation to internal exposure to pollutants. Serum levels of pollutants and sex hormones were measured in 1679 participants selected as a random sample of the adolescents residing in the study areas. Data on sexual development were obtained from the medical school examination files. Self-assessment questionnaires provided information on health, use of medication and lifestyle factors. In boys, serum levels of hexachlorobenzene (HCB), p,p 0 -DDE and polychlorinated biphenyls (sum of marker PCB138, 153 and 180) were significantly and positively associated with pubertal staging (pubic hair and genital development). Higher levels of serum HCB and blood lead were associated with, respectively, a lower and a higher risk of gynecomastia. In girls, significant and negative associations were detected between blood lead and pubic hair development; higher exposure to PCBs was significantly associated with a delay in timing of menarche. Environmental exposures to pollutants at levels actually present in the Flemish population are associated with measurable effects on pubertal development. However, further understanding of toxic mode of action and sensitive windows of exposure is needed to explain the current findings.

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Section: Discussionmentioning

confidence: 71%

Internal exposure to pollutants and sexual maturation in Flemish adolescents

Hond

Dhooge

Bruckers

et al. 2010

J Expo Sci Environ Epidemiol

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“…Vasiliu et al (2004) have reported early timing of menarche after presumable prenatal/early postnatal exposure. In boys, Den Hond et al (2011) have observed early puberty after prepubertal exposure to DDE (DDT) but normal timing after exposure in early life (Gladen et al, 2000). An interesting study based on PCBs and DDE levels in cord blood versus serum levels in adolescence has shown that the neonatal levels only are predictive of slightly smaller testes (Grandjean et al, 2012).…”

Section: Critical Windows Of Exposure To Endocrine Disrupters and Timmentioning

confidence: 99%

“…In addition, lower LH and testosterone levels in serum suggest a delayed puberty of central origin (Grandjean et al, 2012). In the other studies on PCBs and dioxins, the vast majority of investigations after prenatal and/or early postnatal exposure conclude to normal pubertal timing both in girls (Vasiliu et al, 2004;Yang et al, 2005;Warner et al, 2004) and in boys (Gladen et al, 2000;Mol et al, 2002) while Guo et al report delayed puberty in boys (Guo et al, 2004) and Leijs et al late breast development in girls (Leijs et al, 2008). The data after prepubertal exposure are equivocal.…”

Section: Critical Windows Of Exposure To Endocrine Disrupters and Timmentioning

confidence: 99%

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Parent

Franssen

Fudvoye

et al. 2015

Frontiers in Neuroendocrinology

160

140

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Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such distortion of distribution is a recent phenomenon. This suggests changing environmental influences including the possible role of nutrition, stress and endocrine disruptors. Our ability to assess neuroendocrine effects and mechanisms is very limited in humans. Using the rodent as a model, we examine the impact of environmental factors on the individual variations in pubertal timing and the possible underlying mechanisms. The capacity of environmental factors to shape functioning of the neuroendocrine system is thought to be maximal during fetal and early postnatal life and possibly less important when approaching the time of onset of puberty.

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“…To our knowledge, no study has specifically evaluated breast cancer risk in consumers of diets potentially high in PCBs, DDT/DDE, and PBDEs such as consumers of high amounts of sport-caught fish, anglers, families who operate charter fishing boats, or native populations, although several other health parameters, including fecundability (Buck et al 2000;McGuinness et al 2001), birth size (Fein et al 1984), puberty growth (Gladen et al 2000), and cognitive functioning (Jacobson et al 1990;Schantz et al 2001), have been investigated in these adult subpopulations as well as in children.…”

Section: Discussionmentioning

confidence: 99%

Potential exposure to PCBs, DDT, and PBDEs from sport-caught fish consumption in relation to breast cancer risk in Wisconsin.

McElroy¹,

Kanarek²,

Trentham‐Dietz³

et al. 2004

Environ Health Perspect

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In Wisconsin, consumption of Great Lakes fish is an important source of exposure to polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane (DDT), polybrominated diphenyl ethers (PBDEs), and other halogenated hydrocarbons, all of which may act as potential risk factors for breast cancer. We examined the association between sport-caught fish consumption and breast cancer incidence as part of an ongoing population-based case-control study. We identified breast cancer cases 20-69 years of age who were diagnosed in 1998-2000 (n = 1,481) from the Wisconsin Cancer Reporting System. Female controls of similar age were randomly selected from population lists (n = 1,301). Information about all sport-caught (Great Lakes and other lakes) fish consumption and breast cancer risk factors was obtained through telephone interviews. After adjustment for known and suspected risk factors, the relative risk of breast cancer for women who had recently consumed sport-caught fish was similar to women who had never eaten sport-caught fish [relative risk (RR) = 1.00; 95% confidence interval (CI), 0.86-1.17]. Frequency of consumption and location of sport-caught fish were not associated with an increased risk of breast cancer. Recent consumption of Great Lakes fish was not associated with postmenopausal breast cancer (RR = 0.78; 95% CI, 0.57-1.07), whereas risk associated with premenopausal breast cancer was elevated (RR = 1.70; 95% CI, 1.16-2.50). In this study we found no overall association between recent consumption of sport-caught fish and breast cancer, although there may be an increased breast cancer risk for subgroups of women who are young and/or premenopausal.

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Pubertal growth and development and prenatal and lactational exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene

Cited by 255 publications

References 25 publications

Internal exposure to pollutants and sexual maturation in Flemish adolescents

Internal exposure to pollutants and sexual maturation in Flemish adolescents

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Potential exposure to PCBs, DDT, and PBDEs from sport-caught fish consumption in relation to breast cancer risk in Wisconsin.

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