Puberté précoce secondaire à un germinome intramédullaire

Monléon, J.V. de; Simonin, G.; Pincemaille, O; Buttin, C.; Sarles, J.

doi:10.1016/s0929-693x(99)80073-6

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…21 Because the pubertal development of our patient was complete, like those referred to by Sasaki, 16 Takahashi, 21 and their colleagues, the ␤-HCG secretion was not able to produce any detectable systemic endocrine alteration as described earlier. 3,5 As a matter of fact, the presenting symptoms of our patient were merely related to the neurological impairment secondary to the lumbar location of the tumor and were therefore more easily attributable, due to the age of the young man, to a glial tumor such as an ependymoma, which was the first diagnosis.…”

Section: Discussionmentioning

confidence: 78%

“…[2][3][4][5][6][7][8][9][11][12][13]15,[19][20][21] Of these cases, only five had a ␤-HCG-secreting component like the one that we have described; 15,20,21 our case is only the second one reported in the literature in which the patient is not Asian. 3 The two patients reported on by Hisa, 5 de Monléon, 3 and their colleagues were young children who presented at diagnosis with features typical of precocious puberty and required medical attention before neurological symptoms appeared. This kind of clinical history is not exceptional when dealing with secretory germ cell tumors, with the tumors noted both in gonadal and extragonadal locations.…”

Section: Discussionmentioning

confidence: 94%

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Unusual primary secreting germ cell tumor of the spine

Massimino

Gandola

Spreafico

et al. 2006

SPI

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✓ The authors describe a young man with a rare primary spinal germ cell tumor that secreted β–human chorionic gonadotropin. The tumor was resected, and six courses of adjuvant chemotherapy consisting of cisplatin, bleomycin and etoposide were administered together with irradiation to the craniospinal area. An additional dose of radiation was delivered to the tumor site after the first four chemotherapy sessions. The patient was well without any neurological deficit or iatrogenic sequela 33 months after diagnosis. The occurrence of this rare tumor located primarily in the spine warrants attention in pathological studies of spinal tumors in young patients.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 94%

Unusual primary secreting germ cell tumor of the spine

Massimino

Gandola

Spreafico

et al. 2006

SPI

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Intramedullary spinal cord germinoma expresses the protooncogene c-kit

Watanabe

Horikoshi

Naganuma

et al. 2005

Acta Neurochir (Wien)

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A 33-year-old woman first noticed numbness in the both lower extremities and the numbness gradually extended up to the thorax. Magnetic resonance (MR) imaging demonstrated a mass with moderate and heterogeneous enhancement and peritumoural intramedullary cysts in the spinal cord at the T-1 to T-3 levels. The tumour was explored partially and intra-operative pathological examination demonstrated the so-called "two-cell pattern" typical of germinoma. The margin of the tumour was not clear. Histological examination showed germinoma with strong c-kit protein expression on the tumour cell surface. Chemotherapy and radiation therapy were given following surgery. Her neurological deficits were improved but not resolved.

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Aggressive spinal germinoma with ascending metastases

Tekkök

Sav

2005

J Neurooncol

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We report the case of a 28-year-old young man who presented with progressive paraparesis and urinary incontinence. Initial spinal MR scans showed a sausage-like lesion that extended between L1 and S2. At surgery, an encapsulated intradural extramedullary tumor was removed en bloc. The initial histopathological diagnosis was ependymoma. The tumor recurred locally to double its original size only 4 months later. After second surgery, 5,100 cGy of local spinal radiation was given since the pathologist believed that the new tumor exhibited anaplastic features. Subsequently tumor recurred at T6-10 levels and later in the right parasellar region. Surgery was undertaken for both recurrences and radiation to whole spine and to whole brain respectively followed surgery. At 11 months after the initial presentation, a new tumor was diagnosed at T11-T12 levels. After fifth surgery, chemotherapy with cisplatin, doxorubicin and vincristine was started. At this stage, review of all five surgical specimens by an outside neuropathologist was considered crucial. The new and correct histological diagnosis was germinoma. A new chemotherapy regimen targeted for germinoma was then started. The patient remains alive with no evidence of disease at 22 months after initial presentation. Primary spinal germinomas are exceedingly rare. A review of the literature revealed only 14 biopsy-proven spinal germinoma cases. Our case is clearly unique in aggressivity of the tumor, a feature often unexpected for germinomas. This case proves that the dissemination risk may be very serious for germinomas and that the craniospinal radiation may be a more secure treatment mode.

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Puberté précoce secondaire à un germinome intramédullaire

Cited by 7 publications

References 13 publications

Unusual primary secreting germ cell tumor of the spine

Unusual primary secreting germ cell tumor of the spine

Intramedullary spinal cord germinoma expresses the protooncogene c-kit

Aggressive spinal germinoma with ascending metastases

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