Puberty Acceleration in Mice. II. Evidence that the Vomeronasal Organ is a Receptor for the Primer Pheromone in Male Mouse Urine1

Kaneko, Naohiro; Debski, Elizabeth A.; Wilson, Melba C.; Whitten, W. K.

doi:10.1095/biolreprod22.4.873

Cited by 104 publications

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“…VNO neurons send axonal projections to the accessory olfactory bulb (AOB) located dorsal to the most posterior portion of the MOB. Axons of AOB neurons indirectly project to specific nuclei of the amygdala and of the ventromedial hypothalamus that are involved in reproductive and aggressive behaviors (Winans and Scalia, 1970;Wysocki and Meredith, 1991;Kaneko et al, 1980). Information coded from chemical communication cues detected by the VNO can thus readily influence the central control of reproductive physiology and behavior (Meredith, 1983;Winans et al, 1982).…”

mentioning

confidence: 99%

Involvement of Gq/11 in signal transduction in the mammalian vomeronasal organ

Wekesa

Miller

Napier

2003

Journal of Experimental Biology

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confidence: 99%

Involvement of Gq/11 in signal transduction in the mammalian vomeronasal organ

Wekesa

Miller

Napier

2003

Journal of Experimental Biology

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“…In particular, these effects can only be triggered by exposure to the conspecific urine, suggesting that they are related to the peculiar chemical composition of the stimuli. Most priming pheromones elicit physiological effects by acting on the vomeronasal organ, since lesions of the vomeronasal organ or the accessory olfactory bulb prevent pheromonal effects, while lesions of the main olfactory system do not impair pheromonal communication (Kaneko, Debski, Wilson & Whitten, 1980;Keverne, 1983). Accessory olfactory system stimulation, in turn, increases both dopaminergic activity in the hypothalamus (Dluzen, Guan & Vandenbergh, 1992), and luteinizing hormone (LH) release from the hypophysis, so that ultimately reproductive behaviour is affected (Bronson & Maruniak, 1976).…”

mentioning

confidence: 99%

“…Sexual maturation of female mice can be either delayed by volatile substances obtained from the urine of females that are housed together (Novotny, Jemiolo, Harvey, Wiesler & Marchlewska-Koj, 1986), or accelerated by components of adult male urine (Vandenbergh, 1969;Vandenbergh, Whitsett & Lombardi, 1975). However, male pheromones are thought not to be volatile since they act through the accessory olfactory system (Kaneko et al 1980). A partial purification of the puberty-accelerating pheromone from male mouse urine has indicated that it could be bound to a protein or part of a protein (Vandenbergh et al 1975;Vandenbergh, Finlayson, Dobrogosz, Dills & Kost, 1976), but the active substance, probably a peptide, has never been characterized further.…”

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confidence: 99%

Acceleration of puberty onset in female mice by male urinary proteins.

Mucignat‐Caretta¹,

Caretta²,

Cavaggioni³

1995

The Journal of Physiology

166

119

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1. Puberty onset in female mice is accelerated by exposure to conspecific adult male urine, which acts through the vomeronasal organ and the accessory olfactory system. A distinctive component of adult male mouse urine is the major urinary protein complex (MUP), which is a lipocalin; it has a hydrophobic pocket that binds small endogenous volatile molecules. The MUP gene family also codes for a hexapeptide, which has four residues in common with the N‐terminal region of MUP. 2. MUP, the volatiles bound to MUP and the MUP‐related hexapeptide have been tested for the induction of puberty acceleration by measuring the increase in uterus weight related to the first pro‐oestrus phase. MUP, together with its bound volatiles, induces puberty acceleration. Its activity is retained even when the volatiles have been removed either by organic extraction or competition displacement with a high‐affinity ligand. 3. MUP‐related hexapeptide also induces puberty acceleration in female mice. In contrast, the odorants bound to MUP do not exert this effect. 4. It is proposed that the vomeronasal organ contains receptors that recognize the short N‐terminal consensus sequence, N‐Glu‐Glu‐Ala‐X‐Ser (where X is a polar residue), common to both MUP and the hexapeptide.

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“…First, there are differ¬ ences in volatility; it appears that the male urinary substance and the signal in the urine of females in oestrus are quite non-volatile (Kaneko, Debski, Wilson & Whitten, 1980;Drickamer & Assmann, 1981). The puberty-delaying signal in the urine of grouped female mice is relatively non-volatile, although there have been some contradictory results in this regard (Keverne, 1979;Drickamer & Assmann, 1981;Lomas & Keverne, 1982).…”

Section: Discussionmentioning

confidence: 99%

Effects of urine from females in oestrus on puberty in female mice

Drickamer¹

1986

Reproduction

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Summary. A series of 9 experiments was conducted to examine various characteristics of the urinary chemosignal found in the urine of oestrous female mice that accelerates the sexual development of conspecific females. This urinary chemosignal was effective in doses as small as 0\m=.\001 ml/day, was present in excreted and bladder urine, required 3 days of treatment starting before Day 29 of age to effect an acceleration of puberty, required a minimum daily exposure of 2 h, and was relatively nonvolatile. In addition the chemosignal from oestrous females was effective in summer but not in winter months, was significantly more effective when collected at the middle or end of the dark portion of the daily cycle than at the beginning of the dark phase or middle of the light phase, and was not affected by food deprivation or shortened photoperiod.

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Puberty Acceleration in Mice. II. Evidence that the Vomeronasal Organ is a Receptor for the Primer Pheromone in Male Mouse Urine1

Cited by 104 publications

References 0 publications

Involvement of Gq/11 in signal transduction in the mammalian vomeronasal organ

Involvement of Gq/11 in signal transduction in the mammalian vomeronasal organ

Acceleration of puberty onset in female mice by male urinary proteins.

Effects of urine from females in oestrus on puberty in female mice

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