Puberty and bone development

Saggese, Giuseppe; Baroncelli, Giampiero I.; Bertelloni, Silvano

doi:10.1053/beem.2001.0180

Cited by 138 publications

(79 citation statements)

References 51 publications

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“…This should not be surprising because it is reasonable to assume that skeletal changes are affected by the actions of sex steroids, growth hormone (GH), and insulin-like growth factors released and active during the adolescent growth period. (20) Our results are consistent with the previous literature, although many previous reports are based mostly on crosssectional data. The prevailing view, which seems to be sustained in the literature, that peak bone mass may be achieved by 30 years of age arose from the pioneering study of Recker and colleagues (1992) suggesting that PBM is achieved in the third decade of life.…”

Section: Discussionsupporting

confidence: 93%

Bone mineral accrual from 8 to 30 years of age: An estimation of peak bone mass

Baxter-Jones

Faulkner

Forwood

et al. 2011

Journal of Bone and Mineral Research

541

385

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Bone area (BA) and bone mineral content (BMC) were measured from childhood to young adulthood at the total body (TB), lumbar spine (LS), total hip (TH), and femoral neck (FN). BA and BMC values were expressed as a percentage of young-adult values to determine if and when values reached a plateau. Data were aligned on biological ages [years from peak height velocity (PHV)] to control for maturity. TB BA increased significantly from À4 to þ4 years from PHV, with TB BMC reaching a plateau, on average, 2 years later at þ6 years from PHV (equates to 18 and 20 years of age in girls and boys, respectively). LS BA increased significantly from À4 years from PHV to þ3 years from PHV, whereas LS BMC increased until þ4 from PHV. FN BA increased between À4 and þ1 years from PHV, with FN BMC reaching a plateau, on average, 1 year later at þ2 years from PHV. In the circumpubertal years (À2 to þ2 years from PHV): 39% of the young-adult BMC was accrued at the TB in both males and females; 43% and 46% was accrued in males and females at the LS and TH, respectively; 33% (males and females) was accrued at the FN. In summary, we provide strong evidence that BA plateaus 1 to 2 years earlier than BMC. Depending on the skeletal site, peak bone mass occurs by the end of the second or early in the third decade of life. The data substantiate the importance of the circumpubertal years for accruing bone mineral. ß

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Section: Discussionsupporting

confidence: 93%

Bone mineral accrual from 8 to 30 years of age: An estimation of peak bone mass

Baxter-Jones

Faulkner

Forwood

et al. 2011

Journal of Bone and Mineral Research

541

385

View full text Add to dashboard Cite

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“…Adolescence is a critical time for the acquisition of bone mass, around 40% of skeletal mass is acquired during pubertal maturation [32], and vitamin D is known to play an important role in this bone gain during adolescence. Moreover, it has been reported that pubertal girls with hypovitaminosis D are at risk of failing to achieve maximum peak bone mass [24], which suggests that the genes of any component of the vitamin D endocrine pathway are candidate loci of the osteoporosis gene.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism in vitamin D receptor is associated with bone mineral density in patients with adolescent idiopathic scoliosis

2010

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Low bone mass and osteopenia have been reported in the axial and peripheral skeleton of adolescent idiopathic scoliosis (AIS) patients. Furthermore, several recent studies have shown that gene polymorphisms are related to osteoporosis. However, no study has yet linked polymorphisms in the vitamin D receptor (VDR) gene and bone mass in AIS. Accordingly, the authors examined the association between bone mass and VDR gene polymorphisms in 198 girls diagnosed with AIS. The VDR BsmI (rs1544410), FokI (rs2228670) and Cdx2 (rs11568820) polymorphisms and bone mineral density at the lumbar spine (LSBMD) and femoral neck (FNBMD) were analyzed and compared to their levels in healthy controls. Mean LSBMD and FNBMD in AIS patients were lower than in age-and sex-matched healthy controls (P = 0.0022 and P = 0.0013, respectively). A comparison of genotype frequencies in AIS patients and controls revealed a significant difference for the BsmI polymorphism only (P = 0.0054). Furthermore, a significant association was found between the VDR BsmI polymorphism and LSBMD. In particular, LSBMD in AIS patients with the AA genotype was found to be significantly lower than in patients with the GA (P \ 0.05) or GG (P \ 0.01) genotypes. However, no significant association was found between LSBMD or FNBMD and the VDR FokI or Cdx2 polymorphisms. These results suggest that the VDR BsmI polymorphism is associated with LSBMD in girls with AIS.

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“…1,2 Ao final da adolescência, espera-se que cerca de 90% do pico de massa óssea de um indivíduo tenha sido alcançado. 3 Se por um lado as elevadas taxas de acú-mulo de massa óssea observadas durante a adolescência tornam esse período crucial para o desenvolvimento de estratégias de prevenção da osteoporose, há que se considerar que fatores que afetam negativamente o acúmulo de massa óssea neste período potencialmente contribuem para a maior susceptibilidade ao desenvolvimento futuro da doença.…”

Section: Introductionunclassified

Nutrição e outros aspectos relevantes para a saúde óssea na adolescência

Chain

Diogenes

Crivelli

et al. 2015

Revista Hospital Universitário Pedro Ernesto

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73Artigo de revisão Resumo A maior fragilidade e o consequente aumento do risco de fraturas que caracterizam a osteoporose são derivados dos processos de perda de massa óssea e deterioração microestrutural ao longo do tempo. Esses processos têm origem complexa e multifatorial, com reconhecida influência predominante de fatores genéticos. Em função de que os tratamentos disponíveis não restauram significativamente o osso já perdido, existe um crescente interesse na prevenção da doença. Garantir condições favoráveis para o ritmo adequado de aquisição óssea na adolescência contribui para o alcance de um pico ótimo de massa óssea no início da vida adulta que, por sua vez, vem sendo considerado o principal método de prevenção da osteoporose. Alguns dos aspectos relevantes para a aquisição óssea do adolescente são tratados nessa revisão. Nutrição, atividade física e condições fisiológicas associadas à adolescência com potencial impacto sobre a taxa de acúmulo ósseo nesse período são abordadas. A potencial influência da composição corporal é também discutida. Abstract Nutrition and other relevant aspects for bone health in adolescenceThe increase in bone fragility and susceptibility to fracture that characterize osteoporosis are derived from the processes of bone loss and micro architectural deterioration over time. These processes have complex and multifactorial origin with recognized predominant influence of genetic factors. Considering that available treatments do not significantly restore bone already lost, there is a growing interest in preventing the disease. Ensuring conditions that favor an adequate bone mass acquisition in adolescence contributes to the achievement of an optimal peak bone mass in early adulthood, which has been considered the primary method of preventing osteoporosis later in life. Some of the relevant aspects for adolescent bone acquisition are considered in this review. Nutrition, physical activity and physiological conditions associated with adolescence with potential impact on bone accumulation rate in this period are addressed. The potential influence of body composition is also discussed.Keywords: Bone density; Adolescent nutrition; Body composition; Osteoporosis. Nutrição e outros aspectos relevantes para a saúde óssea na adolescência ResumenNutrición y otros aspectos relevantes para la salud ósea en la adolescencia La mayor fragilidad ósea y el consiguiente aumento del riesgo de fracturas que caracterizan la osteoporosis se derivan de los procesos de pérdida de masa ósea y deterioro micro estructural a lo largo del tiempo. Estos procesos tienen origen complejo y multifactorial con reconocida influencia predominante de los factores genéticos. Ya que los tratamientos disponibles no restauran significativamente el hueso ya perdido, hay un creciente interés en la prevención de la enfermedad. Garantizar condiciones que favorezcan el ritmo adecuado de adquisición ósea durante la adolescencia, contribuye a alcanzar un máxi-mo óptimo de masa ósea en la edad adulta temprana, que a su vez ha s...

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Puberty and bone development

Cited by 138 publications

References 51 publications

Bone mineral accrual from 8 to 30 years of age: An estimation of peak bone mass

Bone mineral accrual from 8 to 30 years of age: An estimation of peak bone mass

Polymorphism in vitamin D receptor is associated with bone mineral density in patients with adolescent idiopathic scoliosis

Nutrição e outros aspectos relevantes para a saúde óssea na adolescência

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